The effect of retinyl-palmitate on the level of pro and anti-inflammatory cytokines in multiple sclerosis patients: A randomized double blind clinical trial

Bitarafan, Sama; Mohammadpour, Zinat; Jafarirad, Sima; Harirchian, Mohammad-Hossein; Yekaninejad, Mir Saeed; Saboor-Yaraghi, Ali Akbar

doi:10.1016/j.clineuro.2019.01.003

Cited by 9 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Another RCT of 101 patients reported that the use of vitamin A 25 000 IU daily for 6 months, followed by 1000 IU daily for 6 months, reduced fatigue and depression. 6 Neither study reported other clinical or radiologic outcomes.…”

Section: Vitaminsmentioning

confidence: 97%

“…Toxic effects can be assessed by checking for serum retinyl esters, which are normally not present (Table 1). [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][27][28][29][30] Vitamin B 1 Thiamine acts as a cofactor for several key biochemical enzymes including α-ketoglutarate dehydrogenase complex and transketo-lase. α-Ketoglutarate dehydrogenase complex is involved in energy metabolism and glutamate production.…”

Section: Vitaminsmentioning

confidence: 99%

“…8 Thiamine is generally well tolerated, with no data to support ULs (Table 1). [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][27][28][29][30] Vitamin B 2 Riboflavin has antioxidant properties, possibly via its association with the glutathione redux cycle. Riboflavin deficiency in animal models leads to abnormal central and peripheral myelination.…”

Section: Vitaminsmentioning

confidence: 99%

See 2 more Smart Citations

Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis

2018

View full text Add to dashboard Cite

Section: Vitaminsmentioning

confidence: 97%

Section: Vitaminsmentioning

confidence: 99%

Section: Vitaminsmentioning

confidence: 99%

See 1 more Smart Citation

Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis

2018

View full text Add to dashboard Cite

“…In total, nine studies were included for CRP 2 , 44 – 51 , five studies for TNF-α analysis 2 , 44 , 52 – 54 . Nine studies that were ineligible for other analyses were included for IL-6 2 , 52 , 55 – 59 , seven studies were performed in Asia 2 , 21 , 44 , 46 , 52 , 60 , four studies in America 48 , 49 , 61 , and one study in Europe 53 . Except for two studies 46 , 62 , all studies included both male and female participants.…”

Section: Resultsmentioning

confidence: 99%

Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Gholizadeh

Roodi

Abaj

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Vitamin A is an anti-oxidant which has been presumed to act as an anti-infective vitamin in many studies. This study aimed to evaluate the association between vitamin A supplementation and c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) levels in randomized control trials (RCTs) studies on adults. A systematic search was performed on databases including PUBMED, SCOPUS, and the Cochrane library. The studies included were considered for data extraction and subsequently assessed for effect. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were evaluated. Among 13,219 articles 13 studies were included for analysis of CRP and TNF-α, as well as 9 studies included for IL-6 in quality and quantity. The pooled WMD analysis of CRP demonstrated that vitamin A supplementation significantly increased CRP concentration with (WMD: 0.84 mg/L; 95% CI 0.29–1.39, I2 = 0.96.2% and p value < 0.003). However, there was no significant correlation between vitamin A supplementation and lower plasma TNF-α (p < 0.45)). Subgroup analysis by dosage demonstrate significant association between vitamin A supplementation and IL-6 in dosage with 50,000 with (WMD: − 1.53 mg/L; 95% CI − 2.36 to − 0.71, p value < 0.00001) as well as a negative significant association was seen at 44 weeks of supplementation with 50,000 IU/day retinyl palmitate and TNF-a in chronic hepatitis B conditions with (− 0.94 (− 1.19, − 0.69) p < 0.0001). The result of this study demonstrates that supplementation of vitamin A at low and high dosages for short and long durations increases the CRP plasma concentrations on adults and vitamin A supplementation decreases the TNF-α concentrations in chronic hepatitis B on adults. Therefore, there is an inverse association between vitamin A supplementation and plasma and fecal IL-6 concentrations in many infection conditions.

show abstract

“…In this study, four neuroactive drugs have been considered, being effective in the treatment of different CNS disorders. Namely, DMF and PRG employed to treat early or traumatic brain injuries [11,12]; RP for multiple sclerosis [13] and URB597 for animal models of anxiety, depression, and autism spectrum disorders [14] were studied. All drugs are characterized by poor aqueous solubility and slight solubility in ethanol.…”

Section: Nanoparticle Preparationmentioning

confidence: 99%

Nanotechnological Strategies for Administration of Poorly Soluble Neuroactive Drugs

Esposito

Sguizzato

Drechsler

et al. 2020

The 1st International Electronic Conference on Pharmaceutics

View full text Add to dashboard Cite

Many neuroactive drugs are characterized by poor solubility, hampering their therapeutic potential and clinical research studies. For instance, the lipophilic molecules dimethylfumarate, retinyl palmitate, progesterone, and URB597 can be employed in the treatment of relapsing remitting multiple, early brain injury, learning deficits, and/or traumatic brain injuries. In this study, the possibility to encapsulate these drugs in lipid nanoparticles is investigated. Solid lipid nanoparticles and nanostructured lipid carriers have been produced by melt and ultrasonication of stearic triglyceride or a mixture of stearic triglyceride and caprylic/capric triglycerides. Mean diameters and morphology of lipid particles were studied by photon correlation spectroscopy, cryo-transmission electron microscopy, and x-ray diffraction, while encapsulation efficiency and in vitro drug release have been determined by HPLC. A behavioral study was conducted in rats to study the capability of lipid nanoparticles containing URB597 to alter behaviors relevant to psychiatric disorders after intranasal administration. In this regard, the nanoparticle surface has been modified by polysorbate 80 in order to obtain “stealth” nanoparticles. The nanoencapsulation strategy allowed increased drug solubility with respect to unphysiological solvent or solvent mixtures usually employed for animal and clinical studies. In particular, retinyl palmitate solubility in nanostructured lipid carriers has been increased up to eight-fold. Moreover, rat behavioral effects observed by nanoencapsulated URB597 administered intranasally suggest the therapeutic potential of this non-invasive route to treat social dysfunctions, such as autism.

show abstract

The effect of retinyl-palmitate on the level of pro and anti-inflammatory cytokines in multiple sclerosis patients: A randomized double blind clinical trial

Cited by 9 publications

References 24 publications

Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis

Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis

Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Nanotechnological Strategies for Administration of Poorly Soluble Neuroactive Drugs

Contact Info

Product

Resources

About