The effect of Rutin hydrate on Glucocorticoids induced osteoporosis in mandibular alveolar bone in Albino rats (Radiological, histological and histochemical study)

Baraka, Nuha Abdul-Fattah; Ahmed, Naglaa Fathallah; Hussein, S. A.

doi:10.1016/j.sdentj.2022.06.009

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…Histological findings showed that rutin treatment can enhance bone formation in the buccal region, which is most likely due to an interaction between the anti-inflammatory and osteogenic properties of rutin. This finding is consistent with previously published studies which showed that rutin administration to a rat model of osteoporosis in mandibular alveolar bone significantly increases bone formation [ 25 ]. Additional research also showed that rutin facilitates osteoblast differentiation and bone formation [ 26 ].…”

Section: Discussionsupporting

confidence: 94%

Rutin Gel with Bone Graft Accelerates Bone Formation in a Rabbit Model by Inhibiting MMPs and Enhancing Collagen Activities

et al. 2023

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Bone graft techniques are used to compensate for bone loss in areas with deficient regeneration. However, matrix metalloproteases (MMPs) can limit bone formation by degrading extracellular matrices, which are required for bone regrowth. Noteworthily, rutin is a natural flavonoid compound that inhibits the genetic expression of various MMPs. Therefore, rutin may serve as an inexpensive and stable alternative to the growth factors used to accelerate dental bone graft healing. This study aimed to evaluate the potential of mixing rutin gel with allograft bone to accelerate the healing of bone defects in an in vivo rabbit model. Bone defects were surgically induced in New Zealand rabbits (n = 3 per group) and subsequently treated with bone grafts along with rutin or control gel. Overall, treatment with rutin significantly prevented the expression of several MMPs and increased type III collagen in the gingiva around the surgical site. Additionally, rutin-treated animals showed enhanced bone formation with higher bone marrow content in the jawbone defect area compared with the control group. Taken together, these findings demonstrate that rutin gel, when added to bone grafts, quickly enhances bone formation and may serve as a suitable alternative to expensive growth factors for the same purpose.

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Section: Discussionsupporting

confidence: 94%

Rutin Gel with Bone Graft Accelerates Bone Formation in a Rabbit Model by Inhibiting MMPs and Enhancing Collagen Activities

et al. 2023

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“…Several phenolic compounds were elevated in the 25% prune diet, including chlorogenic acid, cinnamic acid, protocatechuic acid, quercetin-3-glucoside, and rutin. Each of the five compounds mentioned has been associated with prevention of bone loss in several models ( Jang et al, 2018 ; Fayed et al, 2019 ; Mo et al, 2019 ; Baraka et al, 2022 ; Hong et al, 2022 ). Of note, chlorogenic acid ( Mo et al, 2019 ) and rutin ( Baraka et al, 2022 ) have been specifically implicated in preventing GIO in rats through alterations in the RANKL/OPG ratio and osteoclast number, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Each of the five compounds mentioned has been associated with prevention of bone loss in several models ( Jang et al, 2018 ; Fayed et al, 2019 ; Mo et al, 2019 ; Baraka et al, 2022 ; Hong et al, 2022 ). Of note, chlorogenic acid ( Mo et al, 2019 ) and rutin ( Baraka et al, 2022 ) have been specifically implicated in preventing GIO in rats through alterations in the RANKL/OPG ratio and osteoclast number, respectively. In both cases, the responses favor reduced osteoclast activity, thus a reduction in early GC-induced bone loss ( Chotiyarnwong and McCloskey, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice

Chargo,

Neugebauer,

Guzior

et al. 2024

Front. Cell Dev. Biol.

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Glucocorticoid-induced osteoporosis (GIO) is a significant side effect of prolonged glucocorticoid (GC) treatment. Chronic GC treatment also leads to trabecular bone loss and gut microbiota dysbiosis in mice. The gut dysbiosis is mechanistically linked to GIO, which indicates that the microbiota can be targeted to prevent GIO. Prunes, a dried fruit and prebiotic, have emerged in the literature as an effective treatment for sex-steroid deficiency induced osteoporosis (primary osteoporosis). Prunes also significantly alter the composition of the gut microbiota in both rodent models and human studies. Therefore, we tested if dietary prune (DP) supplementation could prevent GC-induced bone loss and affect microbiota composition in an established model of GIO. Sixteen-week-old, skeletally mature, female C57BL/6J mice were treated with a subcutaneous 5 mg placebo or prednisolone pellet for 8 weeks and fed an AIN-93M control diet or a diet modified to include 5, 15, or 25% (w/w) dried California prune powder. As expected, GC treated mice developed significant trabecular bone loss in the distal femur. More importantly, as little as 5% DP supplementation effectively prevented trabecular bone loss. Further, dose dependent increases in trabecular bone volume fraction were observed in GC + 15% and GC + 25% DP mice. Amazingly, in the placebo (non-GC treated) groups, 25% DP supplementation caused a ∼3-fold increase in distal femur trabecular bone volume fraction; this sizable bone response has not been previously observed in healthy mice with gut targeted natural treatments. Along with the striking effect on bone health, GC treatment and 25% DP supplementation led to drastic shifts in gut microbiota composition and several specific changes are strongly associated with bone health. Taken together, these results are the first to demonstrate that DP supplementation effectively prevents the negative effects of prolonged GC therapy on trabecular bone health and strongly associates with shifts in the composition of the gut microbiota.

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Jaw osteoporosis: Challenges to oral health and emerging perspectives of treatment

Liu,

Wang,

et al. 2024

Biomedicine & Pharmacotherapy

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The effect of Rutin hydrate on Glucocorticoids induced osteoporosis in mandibular alveolar bone in Albino rats (Radiological, histological and histochemical study)

Cited by 5 publications

References 29 publications

Rutin Gel with Bone Graft Accelerates Bone Formation in a Rabbit Model by Inhibiting MMPs and Enhancing Collagen Activities

Rutin Gel with Bone Graft Accelerates Bone Formation in a Rabbit Model by Inhibiting MMPs and Enhancing Collagen Activities

Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice

Jaw osteoporosis: Challenges to oral health and emerging perspectives of treatment

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