The effect of saliva on dental caries

Stookey, George K.

doi:10.14219/jada.archive.2008.0347

Cited by 176 publications

(130 citation statements)

References 26 publications

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“…Several studies further claim that a reduction in SFR will increase the risk of caries, particularly in PD patients (18,22,23). In our study, higher rates of DMFT were observed in the DM group than in the non-DM group.…”

Section: Referencessupporting

confidence: 59%

Assessment of Oral Health in Peritoneal Dialysis Patients with and without Diabetes Mellitus

et al. 2012

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The incidence of chronic renal failure continues to rise worldwide, and although the oral and dental changes in individuals with this condition have been examined, investigations with diabetic peritoneal dialysis (PD) patients are limited. We therefore examined salivary pH, dry mouth, taste change, and mucosal ulceration in diabetic and nondiabetic uremic patients receiving PD. A total of 49 patients undergoing PD therapy were allocated to either the diabetic or the nondiabetic group. Salivary pH, dry mouth, taste change, and mucosal ulceration were determined for both groups. Salivary flow rate and pH were both lower in the diabetic group. Buffer capacity, dry mouth, taste change, and mucosal ulceration were all increased in that group. These findings were associated with level of glycosylated hemoglobin A1c. Our observations indicate that, compared with nondiabetic PD patients, patients with diabetes exhibit more severe oral uremic symptoms, including dry mouth, burning mouth syndrome, taste change, and mucosal ulcerations. The oral health in these patients should be followed. A broad range of oral symptoms have been reported in end-stage renal disease (ESRD) patients, including gingivitis, dry mouth, ammonia-like odor resulting from a high urea content, mucosal lesions, tooth mobility, malocclusion, and an increased risk of dental erosion because of frequent regurgitation (1-4). In severe renal failure, uremic stomatitis may be present. Enamel hypoplasia has been documented in patients with ESRD whose disease began at an early age (5). Perit Dial IntWhen patients with ESRD also have diabetes mellitus (DM), the oral manifestations of both conditions may be present. It is well established that DM is correlated with a number of oral conditions such as periodontal diseases, dental caries, stomatitis, glossitis, alterations in salivary secretions, taste change, burning mouth syndrome (BMS), oral mucosal lesions, and bacterial, viral, and fungal infections (6,7). Although the oral and dental changes of the general disease condition have been examined, investigations focused on diabetic peritoneal dialysis (PD) patients are limited. The present study therefore examined salivary flow rate (SFR), buffer capacity (BC) and pH, dry mouth, taste change, BMS, and mucosal ulceration in diabetic and nondiabetic uremic patients receiving PD. METHODSA total of 49 patients undergoing PD therapy were recruited from the PD unit, Faculty of Medicine, Ataturk University, Erzurum. Before enrollment, each patient consented to a predefined protocol, and all procedures followed the tenets of the Declaration of Helsinki. The study protocol was approved by the local ethics committee of Ataturk University.All patients were using the twin-bag system, but various kinds of PD fluid were being used. The patients were classified into diabetic (type 1 and type 2) and nondiabetic groups. Patients with a diabetes history of less than 6 months were excluded from the study. Patients who were smokers were also excluded. To classify the degree of met...

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Section: Referencessupporting

confidence: 59%

Assessment of Oral Health in Peritoneal Dialysis Patients with and without Diabetes Mellitus

et al. 2012

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“…A complex set of interactions between acid producing bacteria and fermentable carbohydrates contribute to caries-risk [6,7]. Other factors associated with caries are saliva properties [8], genetic predispositions [9,10], age and immunological status, and behavioral factors like nutrition level and hygiene habits [2,11].…”

Section: Introductionmentioning

confidence: 99%

Proteomic and bioinformatics analysis of human saliva for the dental-risk assessment

et al. 2017

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Open Life Sci. 2017; 12: 248-265 revealed information about potential risk factors associated with the development of caries-susceptibility and provides a better understanding of tooth protection mechanisms.Keywords: saliva; proteins; caries-susceptible; cariesfree; proteomic analysis; bioinformatics IntroductionDental caries, resulting in demineralization of the tooth structure, is ranked among the most prevalent chronic diseases of people worldwide [1][2][3]. Although it is not a lifethreatening disorder, it still represents a serious health issue with a significant effect on general health and quality of life [4,5].A complex set of interactions between acid producing bacteria and fermentable carbohydrates contribute to caries-risk [6,7]. Other factors associated with caries are saliva properties [8], genetic predispositions [9,10], age and immunological status, and behavioral factors like nutrition level and hygiene habits [2,11].The diagnostic assessment using the molecular analysis (e.g., to find protein markers) related to formation of tooth decay at early stages may help to identify risk factors and help with dental screening and personalized dental treatment.Recently, intensive investigation of protein functions in saliva as possible indicators for predicting caries-risk has begun using the state-of-the-art methodologies such as metabolomics, genomics, proteomics and bioinformatics [12].Vitorino et al. [13] published an early proteomic analysis evaluating the proteome of human saliva and the level of protein expression and adsorption on the human dental enamel surface. The authors compared the whole saliva proteome of male individuals having no dental caries to those afflicted with dental caries. Both saliva incubated with hydroxyapatite as well as in vivo extracts from the Abstract: Background: Dental caries disease is a dynamic process with a multi-factorial etiology. It is manifested by demineralization of enamel followed by damage spreading into the tooth inner structure. Successful early diagnosis could identify caries-risk and improve dental screening, providing a baseline for evaluating personalized dental treatment and prevention strategies. Methodology: Salivary proteome of the whole unstimulated saliva (WUS) samples was assessed in caries-free and caries-susceptible individuals of older adolescent age with permanent dentition using a nano-HPLC and MALDI-TOF/TOF mass spectrometry. Results: 554 proteins in the caries-free and 695 proteins in the caries-susceptible group were identified. Assessment using bioinformatics tools and Gene Ontology (GO) term enrichment analysis revealed qualitative differences between these two proteomes. Members of the cariessusceptible group exhibited a branch of cytokine binding gene products responsible for the regulation of immune and inflammatory responses to infections. Inspection of molecular functions and biological processes of caries-susceptible saliva samples revealed significant categories predominantly related to the activity of proteolytic peptidases, ...

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“…Las características de la saliva hacen parte del hués-ped como factores predisponentes para la caries dental, debido a que una disminución de su pH, una deficiente secreción salival y una saliva espesa y viscosa constituyen aspectos de riesgo que pueden influir en una mayor tendencia a presentar caries dental en un individuo 4,5 .…”

Section: Introductionunclassified

“…Así mismo Stookey, se refiere a características de la saliva que podrían tener una relación importante con la aparición de caries dental, como flujo salival, pH, concentración de proteínas y glucosa 5 .…”

Section: Introductionunclassified

Características Salivales Y Otros Factores Asociados Con La Presencia De Caries Dental en Escolares

et al. 2014

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RESUMENObjetivo: identificar las propiedades de la saliva y otros factores que presentan una asociación con la presencia de caries dental en escolares del municipio de Floridablanca Santander. Materiales y métodos: se realizó un estudio observacional analítico de corte transversal, con 75 escolares de ambos géneros de 9 a 11 años de edad, vinculados con una institución educativa de Floridablanca. Se realizó un muestreo probabilístico aleatorio simple y se consideraron variables sociodemográficas (edad, género, grado que cursaba, convivencia, trabajo de los padres, estrato socioeconómi-co), variables relacionadas con hábitos dietéticos, saliva (pH salival, aclaramiento salival y flujo salival), caries dental (índice COP-D, presencia de caries dental no cavitacional), e higiene bucal (índice cuantificado de placa -ICP y frecuencia del cepillado). Se aplicó el consentimiento informado a los padres y asentimiento a los niños para su participación, posteriormente se analizaron los datos con un modelo de regresión múltiple de Poisson. Resultados: el 54,7% de la población fueron mujeres, la edad que predominó fue 10 años (70,7%), la prevalencia de caries dental fue de 57,3%, la probabilidad de presentar caries dental en los escolares de quinto grado de la institución educativa que presentaron un ICP regular fue 1,65 [IC95%:1,00 -2,70] veces comparado con los escolares que presentaron un ICP bajo o alto. No se encontró una asociación estadísticamente significativa entre la presencia de caries dental con el pH y flujo salival. Conclusiones: no se evidenció una asociación entre la caries dental y características salivales. Respecto al índice cuantificado de placa, se evidencia que individuos con ICP regular tienen 1,65 veces más riesgo de tener caries.[Duarte SM, Jaimes M, Osorio JF, Rodríguez KV, Suárez SP, Martínez CA, Aranzazu GC. Características salivales y otros factores asociados con la presencia de caries dental en escolares. Ustasalud 2014;13(2): 130 -135] Palabras clave: Caries dental, Saliva, Propiedades. SALIVARY CHARACTERISTICS AND OTHER ASSOCIATED FACTORS WITH CAVITIES IN SCHOOL CHILDRENABSTRACT Objective: to assess the association between some salivary properties and others factors and the presence of dental caries in schoolchildren in the city of Floridablanca Santander. Methods: an analytical cross-sectional observational study was done with 75 students of both genders from 9-11 years old, who attended the Educational Institution of Floridablanca. Simple random sampling was conducted and sociodemographic variables (age, gender, grade was studying, living, working parents, socioeconomic status), variables related to dietary habits, saliva (salivary pH, salivary clearance and salivary flow), dental caries (COPD, presence of non-cavitational dental caries), and oral hygiene (brushing and frequency ICP) were analyzed. It applies the parents informed consent and assent to children for their participation. Then, the data were analyzed with multiple regression model of Poisson. Results: 54.7% of the population we...

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The effect of saliva on dental caries

Cited by 176 publications

References 26 publications

Assessment of Oral Health in Peritoneal Dialysis Patients with and without Diabetes Mellitus

Assessment of Oral Health in Peritoneal Dialysis Patients with and without Diabetes Mellitus

Proteomic and bioinformatics analysis of human saliva for the dental-risk assessment

Características Salivales Y Otros Factores Asociados Con La Presencia De Caries Dental en Escolares

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