The effect of Sambucus nigra L. extract and phytosinthesized gold nanoparticles on diabetic rats

Opriş, Răzvan Vlad; Tatomir, Corina; Olteanu, Diana; Moldovan, Remus; Moldovan, Bianca; David, Luminiţa; Nagy, András; Decea, Nicoleta; Kiss, Mihai Ludovic; Filip, Gabriela Adriana

doi:10.1016/j.colsurfb.2016.11.033

Cited by 73 publications

(40 citation statements)

References 24 publications

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“…In our study, AuNP treatment significantly reduced the renal oxidative stress by increasing the activities of renal SOD and catalase and by reducing the tissue MDA level. These results were in agreement with previous in vivo studies that showed that AuNPs have antioxidative and anti-hyperglycemic activities in diabetic animal models [13,41].…”

Section: Discussionsupporting

confidence: 93%

Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy

Alomari

Al‐Trad

Hamdan

et al. 2019

Drug Deliv. and Transl. Res.

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Several recent studies have reported that gold nanoparticles (AuNPs) attenuate hyperglycemia in diabetic animal models without any observed side effects. The present study was intended to provide insight into the effects of 50nm AuNPs on diabetic kidney disease. Adult male rats were divided into three groups (n = 7/group): control (nondiabetic, ND), diabetic (D), and diabetic treated intraperitoneally with 50-nm AuNPs (AuNPs + D; 2.5 mg/kg/day) for 7 weeks. Diabetes was induced by a single-dose injection of 55 mg/kg streptozotocin. The result showed that AuNP treatment prevented diabetes-associated increases in the blood glucose level. Reduction in 24-h urinary albumin excretion rate, glomerular basement membrane thickness, foot process width, and renal oxidative stress markers was also demonstrated in the AuNP-treated group. In addition, the results showed downregulation effect of AuNPs in renal mRNA or protein expression of transforming growth factor β1 (TGF-β 1 ), fibronectin, collagen IV, tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor-A (VEGF-A). Moreover, the protein expression of nephrin and podocin, podocyte markers, in glomeruli was increased in the AuNPs + D group compared with the D group. These results provide evidence that 50-nm AuNPs can ameliorate renal damage in experimental models of diabetic nephropathy through improving the renal function and downregulating extracellular matrix protein accumulation, along with inhibiting renal oxidative stress and amelioration of podocyte injury.

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Section: Discussionsupporting

confidence: 93%

Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy

Alomari

Al‐Trad

Hamdan

et al. 2019

Drug Deliv. and Transl. Res.

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“…The exposure of an environmentally relevant concentration of 20 nm citrate-stabilized GNPs to marine bivalve Ruditapes philippinarum did not provoke oxidative damage and therefore cannot be considered toxic to this model organism [ 33 ]. The administration of GNPs functionalized with Sambucus nigra L. extract increased the muscle and systemic GSH/GSSG ratio and decreased MDA levels in the diabetic rats as compared to the non-diabetic group [ 34 ]. Besides increasing the antioxidant defense, the same treatment also reduced metalloproteinases activity and inflammation in the liver tissue of the diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Histopathology of the Liver, Kidney, and Spleen of Mice Exposed to Gold Nanoparticles

et al. 2018

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Gold nanoparticles (GNPs) are biocompatible nanomaterials that are currently researched for biomedical applications such as imaging and targeted drug delivery. In this investigation, we studied the effects of a single dose (injected on day 1) as well as a priming dose (two injections with a gap of one week) of 5 nm, 20 nm, and 50 nm diameter GNPs on the structural and biochemical changes in the liver, kidney, and spleen of mice. The results showed that small sized GNPs (5 nm) produced significant pathological changes in the liver on day 2 that gradually reduced on day 8. The medium (20 nm) and large (50 nm) sized GNPs preferentially targeted the spleen and caused significant pathological changes to the spleen architecture on day 2 that persisted on day 8 as well. There were minimal and insignificant pathological changes to the kidneys irrespective of the GNPs size. The animals that were primed with the pre-exposure of GNPs did not show any aggravation of histological changes after the second dose of the same GNPs. None of the dose regimens of the GNPs were able to significantly affect the markers of oxidative stress including glutathione (GSH) and malondialdehyde (MDA) in all of the organs that were studied. In conclusion, the size of GNPs plays an important role in their pathological effects on different organs of mice. Moreover, the primed animals become refractory to further pathological changes after the second dose of GNPs, suggesting the importance of a priming dose in medical applications of GNPs.

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“…This negative impact of the above mentioned synthetic methods led to development of new green, eco-friendly synthetic approaches, which use biological resources both as reducing and capping agents of the synthesized nanoparticles. The green synthesis route of noble metal nanoparticles employs natural bioagents like plants [5][6][7], algae and microorganisms such as fungi, bacteria and viruses [8][9][10]. Obtaining nanoparticles by biological means has the advantage of being an eco-friendly, one step, low cost, energy efficient and easy scaling up method.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Biogenic Silver Nanoparticles for Efficient Catalytic Removal of Harmful Organic Dyes

2020

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The present article reports an environmentally benign method for synthesizing silver nanoparticles using the fruit extract of Viburnum opulus L. as a source of bioactive compounds, which can act as reducing agents of the silver ions and also as stabilizing agents of the obtained nanoparticles. The catalytic ability of the synthesized silver nanoparticles (AgNPs) to remove toxic organic dyes was also evaluated. The biosynthesis of silver nanoparticles was firstly confirmed by UV-Vis spectral analysis, which revealed the presence of the characteristic absorption peak at 415 nm corresponding to the surface plasmon vibration of colloidal silver. Fourier-transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) studies were conducted to confirm the presence of bioactive phytocompounds, especially phenolics, as capping and stabilizing agents of the AgNPs. The size, morphology and crystalline nature of the synthesized AgNPs were investigated by transmission electron microscopy and X-ray diffraction techniques revealing that the obtained nanoparticles were spherical shaped, with an average diameter of 16 nm, monodispersed, face centered cubic nanoparticles. Further, the catalytic ability in the degradation of tartrazine, carmoisine and brilliant blue FCF dyes by NaBH4 was evaluated. The results demonstrated an efficient activity against all the investigated dyes being an outstanding catalyst for the degradation of brilliant blue FCF. This eco-friendly synthetic approach can generate new tools useful in environmental pollution control.

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The effect of Sambucus nigra L. extract and phytosinthesized gold nanoparticles on diabetic rats

Cited by 73 publications

References 24 publications

Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy

Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy

Histopathology of the Liver, Kidney, and Spleen of Mice Exposed to Gold Nanoparticles

Green Synthesis of Biogenic Silver Nanoparticles for Efficient Catalytic Removal of Harmful Organic Dyes

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