The effect of scalp electroacupuncture combined with Memantine in patients with vascular dementia

Yue, Ai-Xia; Han, Xiuqing; Mao, Enxia; Wu, Guangling; Gao, Jun; Huang, Liping; Zhou, Bin

doi:10.1097/md.0000000000021242

Cited by 5 publications

(8 citation statements)

References 62 publications

(56 reference statements)

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“…Acupuncture treatment can significantly increase the activity of SOD in the brain and reduce brain tissue damage caused by free radicals, indicating that the results in memory consolidation are closely correlated with changes in LPO and SOD in the brain [12]. In addition to this, the development of intelligence with acupuncture can be influenced through a routine and continuous stimulation process [10].…”

Section: Discussionmentioning

confidence: 99%

“…This is because the Zhu Scalp acupuncture method works on the principle of reducing the level of lipid peroxidation in the brain, increasing the body's ability to scavenge reactive oxygen species, and oxidizing and preventing further damage, thereby contributing to patient recovery [18]. In Zhu Scalp the eding zone area is able to increase enthusiasm, eliminate fear, increase concentration and help the flow of qi and blood to the brain to be smooth so that the brain has sufficient nutrition to carry out its functions [12].…”

Section: Discussionmentioning

confidence: 99%

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The Effectiveness of Zhu Scalp Acupuncture and Body Acupuncture Therapy Methods on Increasing Intellectual Quotients and Emotional Quotients in Pre-School Children

Christiyawati

Estuningsih

2022

Open Access Maced J Med Sci

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BACKGROUND: Intellectual Quotients (IQ) is the ability to act purposefully, think rationally, and deal effectively with the environment. Emotional Quotients (EQ) includes empathy, expressing and understanding, feeling, controlling anger, independence, adaptability, liking, interpersonal problem-solving ability, perseverance, solidarity, friendliness, and respect; important for a person's success. Acupuncture therapy with Zhu Scalp and body acupuncture methods can be used to increase IQ and EQ in children. AIM: This study was to determine the effectiveness of acupuncture therapy with Zhu Scalp acupuncture and body acupuncture methods on the IQ and EQ of pre-school children. METHODS: The research method is a quantitative pre and post-test design with cross-sectional control with a paired T-test. The research sample was pre-school children in Sukoharjo district with a total of 54 respondents. The data collection instrument is a questionnaire for respondent characteristics, IQ test, and EQ measurement using VSMS (Vineland Social Maturity Scale). RESULTS: The research results showed chitosan 5%; a combination of chitosan 9% and snail seromucous 50% (ratio 1: 1) is a microbicide against MTB TB patient isolates. Snail seromucous was ineffective as a microbicide against MTB tuberculosis patients. The results showed that there was a significant difference in the IQ and EQ levels of children before and after acupuncture therapy using the Zhu Scalp method and body acupuncture with a p-value of 0.000. The results of the N Gain test showed that there are differences in the effectiveness of the Zhu Scalp acupuncture and the body acupuncture method on increasing IQ and EQ in pre-school children. CONCLUSION: The Zhu Scalp acupuncture method is more effective than the body acupuncture method to increase IQ and EQ of pre-school age children, which can be applied in the management of acupuncture therapy to improve child development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Zhu Scalp Acupuncture and Body Acupuncture Therapy Methods on Increasing Intellectual Quotients and Emotional Quotients in Pre-School Children

Christiyawati

Estuningsih

2022

Open Access Maced J Med Sci

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“…Dementia refers to a group of brain disorders that affect memory, reasoning, judgment, executive function, practice, visuospatial ability, and language that is not part of delirium or other major mental disorders. Vascular dementia accounts for 15%–20% of all cases of dementia patients and is the second most common type of dementia, just below AD 45 . The development of vascular cognitive impairment and vascular dementia is associated with the presence of damaging factors such as blockage and narrowing of blood vessels 46 .…”

Section: Memantine's Therapeutic Potential For Other Diseasesmentioning

confidence: 99%

“…Therefore, patients with cerebrovascular and cardiovascular disease are more likely to develop vascular dementia than normal individuals 47 . Unlike AD, no drug is clearly effective for vascular dementia, for which there is currently no approved treatment 45,48 . There is an urgent need to explore the pathogenesis and treatment methods of vascular dementia.…”

Section: Memantine's Therapeutic Potential For Other Diseasesmentioning

confidence: 99%

Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications

Tang

Wang

Ren

2023

Ibrain

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Memantine is a noncompetitive moderate‐affinity strong voltage‐dependent N‐methyl‐D‐aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since 1989. In 2018, it became the second most commonly used drug for the treatment of dementia in the world. AD is nonreversible, and memantine can only relieve the symptoms of AD but not cure it. Over the past half‐century, memantine's research and clinical application have been extensively developed. In this review, the basic composition of memantine, the mechanism and limitations of memantine in the treatment of AD, memantine combination therapy, comparison of memantine with other drugs for AD, and clinical studies of memantine in other diseases are reviewed to provide a valuable reference for further research and application of memantine for the treatment of AD.

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“…It is simple, convenient, economical and effective, and has been widely used in clinical practice in China [11]. Studies have demonstrated that electroacupuncture can improve cognitive impairment and learning and memory ability in patients with VaD by reducing inflammatory response [12,13] but the exact mechanism by which electroacupuncture reduces inflammatory response remains unclear. In this study, we use electroacupuncture intervened therapy VaD rats, aiming to explore whether electroacupuncture inhibits inflammation and improves cognitive function damage in rats is mediated by the Sirt1/STAT3 signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats

Zhao¹,

Li²,

Wang³

et al. 2022

NeuroReport

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Objective Inflammation has long been considered a key factor in learning and memory impairment in patients with vascular dementia (VaD). Studies have confirmed that electroacupuncture can improve the learning and memory impairment of patients with VaD by reducing inflammation, but the specific mechanism of this effect is still unclear. The aim of this study was to explore the underlying mechanism of electroacupuncture in the treatment of VaD. MethodsThe vascular dementia animal model was established by bilateral occlusion of common carotid arteries, and electroacupuncture treatment was given at Baihui (DU20) and Zusanli (ST36). The morris water maze (MWM) was used to test the spatial learning and memory ability of rats in each group. To evaluate the expression of Sirtuin1 (Sirt1), Signal transducer and activator of transcription 3 (STAT3) and inflammatory cytokine (IL-17) in the hippocampus and amygdala, immunohistochemistry and western blot were performed. Results:The MWM test and Nissl staining results show that electroacupuncture can significantly improve the learning and memory impairment of VaD rats, and can repair damaged neurons. Immunohistochemistry and western blot results showed that electroacupuncture could enhance the expression of sirt1 in VaD rats, on the contrary, the expression of STAT3 and IL-17 was reduced due to electroacupuncture. ConclusionsThe result suggests that electroacupuncture can suppress inflammation through the Sirt1/STAT3 pathway and improve spatial learning and memory in VaD rats.

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The effect of scalp electroacupuncture combined with Memantine in patients with vascular dementia

Abstract: Supplemental Digital Content is available in the text

Cited by 5 publications

References 62 publications

The Effectiveness of Zhu Scalp Acupuncture and Body Acupuncture Therapy Methods on Increasing Intellectual Quotients and Emotional Quotients in Pre-School Children

The Effectiveness of Zhu Scalp Acupuncture and Body Acupuncture Therapy Methods on Increasing Intellectual Quotients and Emotional Quotients in Pre-School Children

Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications

The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats

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