The effect of selective 5‐hydroxytryptamine uptake inhibitors on 5‐methoxy‐N,N‐dimethyltryptamine‐induced ejaculation in the rat

Rènyi, Lucy

doi:10.1111/j.1476-5381.1986.tb14580.x

Cited by 45 publications

(13 citation statements)

References 30 publications

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“…These authors postulated that 5-HT was acting on autoreceptors to inhibit their firing and release of 5-HT from projection sites. In contrast, augmentation of 5-HT activity also elicits spontaneous erections and ejaculatory responses (Berendsen and Broekktamp 1987;Renyi 1986). Therefore, 5-HT may have both facititatory and inhibitory effects on sexual function depending on the receptor subtype, location of receptors and the animal model.…”

Section: Discussionmentioning

confidence: 96%

A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes

1992

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Neurons in the region of the rostral nucleus paragigantocellularis (nPGi) mediate the inhibition of spinal sexual reflexes. Anatomical and pharmacological evidence is presented supporting a role for 5-hydroxytryptamine (5-HT) in this inhibition. Neurons in the rostral nPGi project to the ventral horn in the vicinity of the pudendal motoneurons. A significant number (78% ipsilateral) of these neurons contain 5-HT. Anterograde tracing with Phaseolus leucoagglutinin (PHA-L) confirmed the nPGi projection to pudendal motoneuron and interneuronal areas of the lumbar cord. 5-HT immunoreactive fibers and presumptive terminals surround the pudendal motoneurons. Urethral stimulation, in the anesthetized male rat, elicited penile erections, ejaculation and rhythmic contractions of the perineal muscles, we have used the term coitus reflex to describe this response. Intrathecal injection of 5-HT (4-50 micrograms) abolished the coitus reflex. Methysergide (1-10 mg/kg i.v.) prevented the 5-HT induced blockade of the coitus reflex. These data support the hypothesis that 5-HT is involved in the descending inhibition of spinal sexual reflexes.

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Section: Discussionmentioning

confidence: 96%

A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes

1992

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“…Pretreatment with the 5-HT synthesis inhibitor p-chlorophenylalanine or 5-HT 1/2 and 5-HT 2 receptor antagonists (methysergide, ritanserin and ketanserin) significantly abolished the ejaculatory response induced by PCA or fenfluramine (26,32,33). In addition, it has been shown that 5-HT 2 receptor agonist 5-methoxydimethyltryptamine facilitates ex copula seminal emission and ejaculation (20,27,28). 5-HT 2 receptors can be divided into three subtypes: 5-HT 2A , 5-HT 2B and 5-HT 2C receptors (11).…”

Section: Drugs and Treatmentsmentioning

confidence: 99%

Synergistic actions of apomorphine and m-chlorophenylpiperazine on ejaculation, but not penile erection in rats

Yonezawa¹,

Yoshizumi²,

Ise³

et al. 2009

Biomed. Res.

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It has been suggested that dopamine (DA) and serotonin (5-HT) and their receptors, particularly D 2 -like and 5-HT 2C receptors, may play a significant role in the control of male sexual function. The purpose of this study was to investigate whether the combination of a dopamine receptor agonist apomorphine and a 5-HT 2 receptor agonist m-CPP would potentiate penile erection and ejaculation in male rats. Systemic administration of either apomorphine (0.01-0.1 mg/kg, s.c.) or m-CPP (0.01-0.3 mg/kg, i.p.) dose-dependently elicited penile erections, but did not induce ejaculation. When combined, there was a drastic increase in both the incidence of ejaculation and the amount of ejaculated seminal materials, while the proerectile effect induced by each drug was not potentiated. The proejaculatory effect induced by the combination of apomorphine (0.1 mg/kg, s.c.) and m-CPP (0.3 mg/kg, i.p.) was completely blocked by pretreatment with the D 2 -like receptor antagonists haloperidol and sulpiride, but not by the D 1 -like receptor antagonist SCH-23390. The synergistic action for ejaculation was also blocked by domperidone, the D 2 -like receptor antagonist that dose not cross the blood-brain barrier. The rats pretreated with the 5-HT 2C receptor antagonist SB242084 did not show the synergistic action by the combination of apomorphine and m-CPP, whereas the rats pretreated with the 5-HT 2A receptor antagonist ketanserin and the 5-HT 2B receptor antagonist SB204741 showed the combination-induced synergistic action. These results suggest that the combination of a small dose of apomorphine and m-CPP potently and selectively facilitates the ejaculatory response through the activation of D 2 -like and 5-HT 2C receptors, respectively. The D 2 -like receptors involved in the synergistic action may be, at least in part, located in the peripheral sites.Ejaculation is defined as a complex physiological process that results in the expulsion of the seminal fluid from the urethral meatus (19,22). This process consists of three distinct phenomena: seminal emission (secretion of the mixed fluids composing semen into the posterior urethra), ejaculation (expulsion of semen from the posterior urethra to the outside), and bladder neck closure. These events occur reflexively, and require coordination of autonomic and somatic nervous systems (7, 9, 16) in order to achieve effective delivery of semen. A variety of neurotransmitters distributed in supraspinal and spinal sites are important for the controling ejaculation. Among the several neurotransmitters, it has been suggested that the dopaminergic and serotonergic systems have both excitatory and inhibitory influences on penile erection and ejaculation at the supraspinal level (10,

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“…This finding is consistent with identification of all three 5-HT, binding sites on spinal cord synaptosomes [Zemlan et al, 19901. In the cat, electrical stimulation of 5-HT-containing neurons in the caudal raphe nucleus, which sends projections to autonomic centers in the sacral spinal cord, inhibits bladder contractions [McMahon and Spillane, 19821. Furthermore, 5-HT agonists that effect the re-uptake or degradation of this monoamine transmitter to promote or inhibit various aspects of sexual behavior in the rat [Berendsen et al, 1990;Bitran and Hull, 1987;Lee et al, 1990;Mas et al, 1987;Renyi, 1986;Steers and de Groat, 1989;Szele et al, 19881. In humans the antidepressant trazodone, whose major metabolic product is the 5-HTIc,, agonist mchlorophenylpiperazine (mCPP), is useful in treating impotence [Adaikin et al, 19911. Likewise, tricyclic antidepressants whose pharmacological actions include blockade of 5-HT uptake are used to manage bladder hyperactivity and pain [Wein et al, 19911.…”

Section: Introductionmentioning

confidence: 99%

Effects of serotonergic agonists on micturition and sexual function in the rat

Steers

Albo

Asselt

1992

Drug Development Research

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Organon 6997 (ORG 6997) had no effect on pelvic nerve-induced detrusor contraction or evoked responses in bladder nerves. 5-HTlc,a agonists abolished reflexly evoked bladder contractions by inhibiting efferent firing in the pelvic nerve. 5-HT, , , , agonists also produced penile erections (2-5130 min) via firing in cavernous nerves mediated by preganglionics in the pelvic nerve. Neural activity in the cavernous nerves following administration of MK212 and TFMPP was abolished by the 5-HTIcln antagonist mianserin. 5-HT,,, 5-HT, B, 5-HT, c/2 agonists failed to influence synaptic transmission in the pelvic ganglion. These data support a functional diversity of 5-HT receptor subtypes with selective excitation or inhibition of central autonomic pathways regulating pelvic visceral function. These observations suggest that 5-HT,c,n agonists could be clinically useful for managing impotence or urinary incontinence. o 1992 Wiley-Liss, Inc.

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The effect of selective 5‐hydroxytryptamine uptake inhibitors on 5‐methoxy‐N,N‐dimethyltryptamine‐induced ejaculation in the rat

Cited by 45 publications

References 30 publications

A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes

A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes

Synergistic actions of apomorphine and m-chlorophenylpiperazine on ejaculation, but not penile erection in rats

Effects of serotonergic agonists on micturition and sexual function in the rat

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