The effect of selective D1 and D2 dopaminergic agents on sexual receptivity in the female rat

Grierson, Jeremy P.; James, Margaret D.; Pearson, JT; Wilson, Catherine

doi:10.1016/0028-3908(88)90169-4

Cited by 49 publications

(29 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although all D1-agonists enabled reproductive behavior in the present study, the more efficacious SKF85174 proved to be significantly more inhibitory than the less potent, weak agonists SKF38393 and SKF77434. This finding is consistent with previous studies (Everitt et al, 1975;Foreman and Moss, 1979;Grierson et al, 1988) in which the effects of SKF38393 were reported. Interestingly, animals treated with SKF75670, a D1-like agonist with little if any cyclase activity in rat striatal tissue, displayed stimulation of behavior at all doses.…”

Section: Discussionsupporting

confidence: 94%

“…The present results support previous studies (Everitt et al, 1975;Everitt and Fuxe, 1977;Foreman and Moss, 1979;Grierson et al, 1988;Mani et al, 1994) indicating that third ventricle administration of dopamine or the selective D1-like agonist SKF38393 facilitates receptivity and extends previous findings to three analogs of SKF38393. In vitro, the four D1-like agonists used in this study possess different relative efficacies [compared with dopamine (100 mM)] for stimulating adenylyl cyclase in rat striatal tissue (Andersen and Jansen, 1990;Undie and Friedman, 1992).…”

Section: Discussionsupporting

confidence: 92%

“…However, the PR can be activated in vitro in a ligand-independent manner by the neurotransmitter dopamine (Tsai and O'Malley, 1994). Dopamine is thought to act selectively through D1-like and D2 receptors (Grierson et al, 1988). Centrally administered dopamine (Mani et al, 1994) and the D1-like agonist SKF38393 (Foreman and Moss, 1979) induce lordosis in rats primed with low doses (5-10 g) of estrogen.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Dopaminergic Regulation of Progesterone Receptors: Brain D5 Dopamine Receptors Mediate Induction of Lordosis by D1-Like Agonists in Rats

Apostolakis

Garai

Fox³

et al. 1996

J. Neurosci.

View full text Add to dashboard Cite

To characterize the signaling pathway by which the neurotransmitter dopamine modulates progesterone receptor (PR) activation, the steroid-dependent behavior lordosis was used in estrogen-primed ovariectomized Sprague-Dawley rats with stereotaxic implanted third ventricle cannulas. Lordosis was observed in response to solicitous males in females after central administration of the D1-like agonist SKF38393 and three of its analogs (SKF77434, SKF75640, and SKF85174). In contrast, D1-like antagonist SCH23390 and D1-like/D2 repopulation inhibitor EEDQ blocked behavior inducible by the D1-like agonists. Further, antisense oligonucleotides to D5, but not D1, dopamine receptor mRNA suppressed reproductive behavior associated with D1-like stimulation. This finding provides strong evidence that dopaminergic modulation of lordosis is mediated by the novel D5 dopamine receptor. Although D1, but not D5, dopamine receptor mRNAs were detected in the ventromedial nucleus (VMN) by in situ hybridization, agonists microinjected into the VMN, but not into the arcuate nucleus or preoptic area, induced lordosis, suggesting the functional presence of D5 dopamine receptors in the VMN. Also in support, D5 receptor mRNA antisense microinjected into the VMN blocked the subsequent induction of lordosis by D1-like agonists. Finally, facilitation of sex behavior by D1-like agonists was blocked by the antiprogestin RU38486 and PR antisense oligonucleotide. Collectively, the data provide strong evidence for dopaminergic modulation of reproductive behavior through D5 dopamine receptor-mediated modulation of PR-dependent behavior in rat CNS. Key words: steroid receptors; D5 dopamine receptors; lordosis; antisense oligonucleotides; progesterone; estrogenIn the female rat, the ovarian steroid hormone estrogen modulates the reproductive behavior lordosis (Pfaff and SchwartzGiblin, 1988). Estrogen effect on lordosis is mediated in part by steroid receptors in the estrogen-concentrating neurons located in the ventrolateral region of the hypothalamic ventromedial nucleus (VMN). The major effect of estrogen on lordosis is thought to be mediated by progesterone receptors (PR), because (1) estrogen induces PR in the VMN, and (2) RU38486 and PR antisense oligonucleotide block the induction of lordosis by progesterone (P) (Pfaff and Schwartz-Giblin, 1988;McCarthy et al., 1993). Thus, the dependence of lordosis on estrogen and progestins can be used in vivo to probe cellular and molecular mechanisms for mammalian behavior.As ligand-dependent nuclear transcription factors, steroid receptors alter the expression of specific genes or gene networks (Evans, 1988). However, the PR can be activated in vitro in a ligand-independent manner by the neurotransmitter dopamine (Tsai and O'Malley, 1994). Dopamine is thought to act selectively through D1-like and D2 receptors (Grierson et al., 1988). Centrally administered dopamine (Mani et al., 1994) and the D1-like agonist SKF38393 (Foreman and Moss, 1979) induce lordosis in rats primed with low doses (5-10 g) of estroge...

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

See 1 more Smart Citation

Dopaminergic Regulation of Progesterone Receptors: Brain D5 Dopamine Receptors Mediate Induction of Lordosis by D1-Like Agonists in Rats

Apostolakis

Garai

Fox³

et al. 1996

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…48,49 On the other Dopamine and sexual function F Giuliano and J Allard hand, apomorphine was found to be able to increase the lordotic response of ovariectomised rats treated with oestrogen and progesterone when given systemically. 50 Stimulation of D 2 receptors by either LY171555 or LY163502 was also found to increase the lordotic response of low receptive ovariectomised oestrogen treated rats.…”

Section: Involvement Of Da In Female Rat Sexual Motivationmentioning

confidence: 99%

“…52 In contrast, selective D 1 agonists and antagonists do not affect measures of proceptivity and receptivity in female rats. 49,51 However injections in discrete brain areas can reveal an effect of D 1 agonist=antagonist on lordosis. For example, a D 1 receptor agonist, but not a D 2 receptor agonist, infused i.c.v., mimicked the effects of progesterone in facilitating sexual behaviours in oestrogen primed, ovariectomised female rats.…”

Section: Involvement Of Da In Female Rat Sexual Motivationmentioning

confidence: 99%

Dopamine and sexual function

Giuliano

Allard²

2001

Int J Impot Res

View full text Add to dashboard Cite

The use of the D 1 =D 2 dopamine receptor agonist apomorphine SL for the treatment of erectile dysfunction provides a strong support in favour of a participation of the dopaminergic system in the control of sexual function. However, the exact involvement of dopamine in sexual motivation and in the control of genital arousal in humans is unknown. In contrast, experimental data suggest an implication of dopamine at all these stages of the copulatory behaviour in rodents. The release of dopamine at the level of the nucleus accumbens, which is innervated by the mesolimbic dopaminergic pathway originating in the ventral tegmental area, is positively implicated in the pre-copulatory or appetitive phase in male rats. There is also a permissive role in the copulatory or consumatory phase for dopamine released at the level of the median pre-optic area, which receives projection from the dopaminergic incertohypothalamic pathway within the hypothalamus. It is noteworthy that these participations of the dopaminergic system are not specific to sexual behaviour but rather reflect the more general involvement of dopamine in the regulation of cognitive, integrative and reward processes. Due to its role in the control of locomotor activity, the integrity of the nigrostriatal dopaminergic pathway is also essential for the display of copulatory behaviour. Somehow more specific to sexual function, it is likely that dopamine can trigger penile erection by acting on oxytocinergic neurons located in the paraventricular nucleus of the hypothalamus, and perhaps on the pro-erectile sacral parasympathetic nucleus within the spinal cord. The counterpart of such regulation of the genital arousal by dopamine has not yet been established in females. In conclusion, the central dopaminergic system is a key element of the control of sexual function.

show abstract

Central Nervous System Anatomy and Neurochemistry of Sexual Desire

Pfaus¹,

Jones²

2018

Textbook of Female Sexual Function and Dysfunction

View full text Add to dashboard Cite

The effect of selective D1 and D2 dopaminergic agents on sexual receptivity in the female rat

Cited by 49 publications

References 37 publications

Dopaminergic Regulation of Progesterone Receptors: Brain D5 Dopamine Receptors Mediate Induction of Lordosis by D1-Like Agonists in Rats

Dopaminergic Regulation of Progesterone Receptors: Brain D5 Dopamine Receptors Mediate Induction of Lordosis by D1-Like Agonists in Rats

Dopamine and sexual function

Central Nervous System Anatomy and Neurochemistry of Sexual Desire

Contact Info

Product

Resources

About