The effect of selenium and/or vitamin E treatments on radiation —induced intestinal injury in rats

Mutlu-Türkoglu, Ü.; Erbil, Yeşim; Öztezcan, Serdar; Olgaç, Vakur; Token, Gülçin; Uysal, Müjdat

doi:10.1016/s0024-3205(00)00516-6

Cited by 106 publications

(47 citation statements)

References 24 publications

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“…As presented in Figure 4, lipid peroxidation, caused by oxygen free radicals (OFR), in UW group was almost 5-fold higher than the other groups. Polysol has optimized OFR scavenging potential, achieved by supplementation of not only glutathione and allopurinol but also ascorbic acid (vitamin C), selenium, glycine and alpha-tocopherol (vitamin E), all of which were proven to be effective as antioxidants upon organ preservation [36][37][38] . Celsior and HTK, include relatively high dose of histidine (Table 1), which neutralizes reactive oxygen species and preserves high-energy phosphates [39] .…”

Section: Discussionmentioning

confidence: 99%

Experimental small bowel preservation using Polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?

Wei

Hata²,

Doorschodt³

et al. 2007

WJG

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AIM:To evaluate the potential of Polysol, a newly developed preservation solution, in cold storage of small bowel grafts, compared with the current standards, University of Wisconsin solution (UW), Celsior and histidine-tryptophan-ketoglutarate solution (HTK). METHODS:Male Wistar rats were used as donors. Small bowels were retrieved, flushed and then stored in the respective 4 solutions for 18 h at 4℃. Functional integrity of the grafts was evaluated by isolated reperfusion with oxygenated Krebs-Henseleit buffer at 37℃ for 30 min in all 4 groups. RESULTS:Polysol preservation exhibited the highest tissue ATP concentration and the lowest release of LDH. Malondialdehyde, an index for tissue lipid peroxidation, w a s a l s o t h e l o w e s t i n Po l y s o l . T i s s u e o x y g e n consumption was significantly higher in Polysol than in the others. Of interest, UW-storage promoted 10-fold higher apoptosis than in the others. Moreover, electron microscopy revealed that the mucosal villi/micro-villi formation and the cell organelles, including mitochondria, were both significantly better preserved in Polysol, while deleterious alterations were apparent in the others, most notably in UW. Although Celsior and HTK exhibited the better trend of results than UW in some parameters, but could not reach the over-all superiority to UW. CONCLUSION:Cold storage using Polysol resulted in significantly better integrity and function of small bowel grafts than UW. Hence, Polysol may be a novel alternative for the small bowel preservation.

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Section: Discussionmentioning

confidence: 99%

Experimental small bowel preservation using Polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?

Wei

Hata²,

Doorschodt³

et al. 2007

WJG

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“…A large number of animal experiments have identified potential physiological mechanisms occurring in the small and large intestine during and after pelvic radiotherapy. Interventional studies using elemental diet, micronutrient supplementation and probiotics suggest that some of these physiological mechanisms can be blocked, leading to significant reduction in radiation damage Bounous, 1972, 1973;Bounous et al, 1973;Pageau et al, 1975;Pageau and Bounous, 1977;McArdle et al, 1985McArdle et al, , 1986McArdle, 1994;Wiseman et al, 1996;Mutlu-Turkoglu et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy

et al. 2004

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Up to 12 000 patients with gynaecological, urological and rectal cancer undergo radical pelvic radiotherapy annually in the UK. More than 70% develop acute inflammatory changes causing gastrointestinal symptoms during treatment because healthy bowel tissue is encompassed in the radiation field. In total, 50% go on to develop chronic bowel symptoms, which affect quality of life due to permanent changes in the small and large intestine. Nutritional intervention may influence acute and chronic bowel symptoms but the validity of the advice given to patients is not clear. To assess the incidence and significance of malnutrition and to examine the efficacy of therapeutic nutritional interventions used to manage gastrointestinal side effects in patients undergoing pelvic radiotherapy and those with chronic bowel side effects after treatment, a critical review of relevant original studies on human subjects was carried out using a specific set of mesh terms in MEDLINE and EMBASE databases and the Cochrane Library in September 2003. Full texts of all relevant articles were collected and reference lists were checked. Sources of grey literature including conference abstracts and webbased information were also reviewed. A total of 36 papers published in peer-reviewed journals between 1966 and 2003 were identified. In all, 14 randomised controlled trials, 12 prospective cohorts, four retrospective, two qualitative, one validation, one pilot study and two case reports were obtained. These included 2646 patients. Eight articles including three conference abstracts and webbased information were found. None of the studies was definitive because of weakness in methodology. No studies could be combined because the interventions and the end points were different. There is no evidence base for the use of nutritional interventions to prevent or manage bowel symptoms attributable to radiotherapy. Low-fat diets, probiotic supplementation and elemental diet merit further investigation.

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“…Since cytotoxic effects of ionizing radiation on gastrointestinal epithelium may be related to oxidative stress, a number of agents have been used as a prophylaxis [117] . In another study, the early side effects of radiation were suggested to be prevented by vitamin A supplementation [118] .…”

Section: Prevention Of Radiation Colitismentioning

confidence: 99%

Recent advances in the management of radiation colitis

Kountouras¹,

Zavos²

2008

WJG

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The effect of selenium and/or vitamin E treatments on radiation —induced intestinal injury in rats

Cited by 106 publications

References 24 publications

Experimental small bowel preservation using Polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?

Experimental small bowel preservation using Polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?

Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy

Recent advances in the management of radiation colitis

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