In two pre-registered and fully incentivized studies (
N
= 501), we investigate prosocial behavior during the COVID-19 pandemic in Germany. Based on a comparison with pre-pandemic data, Study 1 shows that individuals’ general prosociality measured with a (context-independent) Social Value Orientation Slider changed significantly before vs. during the early stage of the pandemic towards increased prosociality. In addition, we identified pandemic-specific context factors for prosocial behavior measured by a series of Dictator games with different recipients. Allocations in the Dictator game increased with the giver's responsibility and the recipients’ vulnerability to the virus. Study 2 replicates and extends this finding in a sample representative for the adult German population in terms of age and gender. We show that, for different actors (self, recipient, politicians), different dimensions of responsibility (responsibility to help, responsibility for the problem cause, and for the solution) are associated with prosocial behavior. Contrary to what could be expected from diffusion of responsibility, prosocial behavior increased not only when individuals themselves felt responsible to help but also when they perceived politicians to be responsible to help. Assigning responsibility for the cause of the COVID-19 crisis to recipients and politicians was associated with a decrease in prosocial behavior. However, responsibility for the solution had no influence. We discuss implications for public policies.