The effect of serotonergic blockade in postpartum preeclamptic patients

Montenegro, Raul; Knuppel, Robert A.; Shah, Dhara; O’Brien, William F.

doi:10.1016/0002-9378(85)90095-x

Cited by 23 publications

(5 citation statements)

References 5 publications

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“…The acute reduction in blood pressure was accompanied by a transient stimulation of the sympathetic system and by a slight transient rise in heart rate [De Cr6e et al, 1981, 1985aDemoulin et al, 1981;Fagard et al, 1984;Wenting et al, 1984;and unpublished data]. Intravenous antihypertensive treatment with ketanserin was found useful in pre-and postoperative hypertension and in hypertensive crises in preeclampsia [Montenegro et al, 1985;Van der Starre et al, 1983;Weiner, 1985;and unpublished data].…”

Section: Acute Antihypertensive and Hemodynamic Effectsmentioning

confidence: 99%

Ketanserin: A novel cardiovascular drug

Symoens

Janssens

1986

Drug Development Research

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Symoens, J. and M. Janssens: Ketanserin: A novel cardiovascular drug. Drug Dev. Res. 8:159-172, 1986. Extensive clinical investigation has shown that ketanserin is an effective first-line antihypertensive agent with particular advantages in older patients. It has a favorable hemodynamic profile and seems devoid of serious side-effects. Clinical studies in various diseases indicate a gradual improvement of the microcirculation, which is compatible with selective serotonin S2-antagonism. Ketanserin has a favorable influence on several cardiovascular risk factors. Preliminary data suggest that it has vascular protective effects in patients with atherosclerosis.

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Section: Acute Antihypertensive and Hemodynamic Effectsmentioning

confidence: 99%

Ketanserin: A novel cardiovascular drug

Symoens

Janssens

1986

Drug Development Research

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“…Earlier studies with ketanserin in hypertensive pregnant women suggested that serotonin may have a role in the modulation of pre‐eclampsia 20,21 . Weiner et al 21 Montenegro et al 22 and Hulme et al 23 have demonstrated that ketanserin is effective in reducing blood pressure in intrapartum and postpartum preeclamptics. In a study of antepartum women Dekker and van Geijn 20 showed that intravenous ketanserin is effective in achieving satisfactory blood pressure control in women with severe pre‐eclampsia resistant to conventional vasodilating medication.…”

Section: Discussionmentioning

confidence: 99%

The haemodynamic effects of ketanserin versus dihydralazine in severe early‐onset hypertension in pregnancy

Bolte

Eyck²,

Schijndel

et al. 1998

BJOG

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Objective To compare the haemodynamic efficacy of ketanserin (a selective serotonin,-receptor blocker) with dihydralazine in the management of severe early-onset hypertension in pregnancy.Design Subgroup analysis within a randomised prospective multicentre trial to compare haemodynamic effects as measured by pulmonary artery catherization.Setting Departments of Obstetrics and Gynaecology and Intensive Care Medicine, Free University Hospital, Amsterdam and Sophia Hospital, Zwolle.Participants Thirty-one women with a diastolic blood pressure > 110 mmHg and a gestational age between 26 and 32 weeks.Results The antihypertensive efficacy of both drugs was comparable. Dihydralazine significantly increased cardiac output (P < O a O l ) , while ketanserin induced only minor changes in cardiac output. Systemic vascular resistance decreased in both groups, but the decrease was significantly more pronounced with dihydralazine compared with ketanserin. Ketanserin induced a significant but not clinically relevant increase in heart rate (P < 0.01, while dihydralazine caused marked tachycardia (P e 0.005). Left ventricular stroke work index was reduced to similar values in both groups. Conclusions The antihypertensive profile of ketanserin is characterised by an early and gradual reduction of blood pressure in combination with a moderate decrease in systemic vascular resistance and no significant change in cardiac output. Dihydralazine causes market tachycardia resulting in a considerable increase in cardiac output.

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“…Pharmacologic and méthodologie advances over the last decade have re sulted in a body of information implicating serotonin as a mediator in the genesis of preeclamptic hypertension [7], Recently, several reports have demonstrated that ketanserin is effective in the treatment of hypertension in preeclampsia. After ketanserin treatment, a signifi cant and comparable decrease in blood pressure was noted and no adverse affects were observed in mother and fetus [8][9][10], Also, ketanserin was effective in acutely reducing elevated postpartum blood pressure in preeclamptic patients [11,12]. during the intrapartum period, ketanserin has effects on cardiac function and produces decline in blood pressure [9,10].…”

Section: Discussionmentioning

confidence: 99%

Effects of Ketanserin – a Serotonin Receptor Antagonist – on Placental Blood Flow, Placental Weight and Fetal Weight of Spontaneously Hypertensive Rats and Normal Wistar Kyoto Rats

Furuhashi

Tsujiei

Kimura

et al. 1991

Gynecol Obstet Invest

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Recently, ketanserin (serotonin receptor antagonist) has been reported to be beneficial in the treatment of preeclampsia. In this study, we investigated the effects of ketanserin on the placental blood flow, fetal weight and placental weight in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). We measured the rats’ placental blood flow by monitoring the clearance of hydrogen gas generated by electrolysis. In ketanserin (12, 24, 48 mg/kg)-treated SHR, systolic blood pressure was significantly decreased. The placental blood flow was significantly (p < 0.05) reduced compared to that before treatment in WKY and SHR. The fetal weight decreased dose dependently in WKY, while in SHR it did not decrease significantly. The placental weight of ketanserin-treated rats decreased compared to that before treatment. These data suggest that ketanserin might have some reducing effects on placental blood flow, fetal weight and placental weight proportional to the dose.

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The effect of serotonergic blockade in postpartum preeclamptic patients

Cited by 23 publications

References 5 publications

Ketanserin: A novel cardiovascular drug

Ketanserin: A novel cardiovascular drug

The haemodynamic effects of ketanserin versus dihydralazine in severe early‐onset hypertension in pregnancy

Effects of Ketanserin – a Serotonin Receptor Antagonist – on Placental Blood Flow, Placental Weight and Fetal Weight of Spontaneously Hypertensive Rats and Normal Wistar Kyoto Rats

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The effect of serotonergic blockade in postpartum preeclamptic patients

Cited by 23 publications

References 5 publications

Ketanserin: A novel cardiovascular drug

Ketanserin: A novel cardiovascular drug

The haemodynamic effects of ketanserin versus dihydralazine in severe early‐onset hypertension in pregnancy

Effects of Ketanserin &ndash; a Serotonin Receptor Antagonist &ndash; on Placental Blood Flow, Placental Weight and Fetal Weight of Spontaneously Hypertensive Rats and Normal Wistar Kyoto Rats

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Effects of Ketanserin – a Serotonin Receptor Antagonist – on Placental Blood Flow, Placental Weight and Fetal Weight of Spontaneously Hypertensive Rats and Normal Wistar Kyoto Rats