The Effect of Shen Qi Wan Medicated Serum on NRK-52E Cells Proliferation and Migration by Targeting Aquaporin 1 (AQP1)

He, Yayi; Yu, Bin; Chen, Hong Shu; Chen, Yi Tao; Zhang, Xiao; Yang, Yuan; Li, Chang Yu

doi:10.12659/msm.922943

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Moreover, the seed mucilage of this quince fruit, a hydrocolloid, has been useful as a bulking and thickening agent in food [ 15 ]. The medicinal properties of this plant reported during ancient times caught the eye of modern scientific researchers that have looked up to isolation of plant active phytochemicals [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ], using their curative potential in response to health challenges [ 24 , 25 , 26 , 27 , 28 , 29 ]. In the past few years, the chemical constituents of quince fruit and its derivatives have been the subject of study [ 13 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Properties of the Leaf of Cydonia Oblonga Mill. Based on Mineral and Organic Profiles

Melo

Oliveira

Lopes

et al. 2022

Plants

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Leaf extract of Cydonia Oblonga Mill. is interesting for further exploration of the potential of its substrates for therapeutic supplements. Quantitative and qualitative analyses were conducted on samples of green (October), yellow (November), and brown (December) quince leaves collected in the region of Pinhel, Portugal. Mineral analysis determined the measurements of the levels of several macro- and micro-elements. Organic analysis assessed the moisture content, total phenolic content (TPC), vitamin E, and fatty acid (FA) profiles. Mineral analysis was based on ICP-MS techniques, while the profiles of vitamin E and FA relied on HPLC-DAD-FLD and GC-FID techniques, respectively. Moisture content was determined through infrared hygrometry and TPC was determined by spectrophotometric methods. Regarding the mineral content, calcium, magnesium, and iron were the most abundant minerals. Concerning organic analysis, all leaf samples showed similar moisture content, while the TPC of gallic acid equivalents (GAE) and total vitamin E content, the most predominant of which was the α-tocopherol isomer, showed significant variations between green-brown and yellow leaves. FA composition in all leaf samples exhibited higher contents of SFA and PUFA than MUFA, with a predominance of palmitic and linolenic acids. Organic and inorganic analysis of quince leaves allow for the prediction of adequate physiological properties, mainly cardiovascular, pulmonary, and immunological defenses, which with our preliminary in silico studies suggest an excellent supplement to complementary therapy, including drastic pandemic situations.

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Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Properties of the Leaf of Cydonia Oblonga Mill. Based on Mineral and Organic Profiles

Melo

Oliveira

Lopes

et al. 2022

Plants

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“…In TCM-related experiments, medicated serum was made usually used to carry out celluer experiments, that is due to most TCM is oral medicine, medicated serum can better reflect the efficacy of TCM, medicated serum is easy to preserve and other factors [ 13 , 14 ]. Another 40 SD rats were purchased for preparation of medicated serum.…”

Section: Methodsmentioning

confidence: 99%

Shen Qi Li Xin formula improves chronic heart failure through balancing mitochondrial fission and fusion via upregulation of PGC-1α

et al. 2021

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Background Our previous study proved that Shen Qi Li Xin formula (SQLXF) improved the heart function of chronic heart failure (CHF) patients, while the action mechanism remains unclear. Methods H&E staining and TUNEL staining were performed to measure myocardial damages. Western blot was used to examine the expression of proteins. Moreover, CCK-8 assay and flow cytometry were used to measure cell viability and cell apoptosis, respectively. Concentrations of ATP and ROS in cells, and mitochondrial membrane potential (MMP) were detected to estimate oxidative stress. Results In vivo, we found that SQLXF improved cardiac hemodynamic parameters, reduced LDH, CK-MB and BNP production, and attenuated myocardial damages in CHF rats. Besides, SQLXF promoted mitochondrial fusion-related proteins expression and inhibited fission-related proteins expression in CHF rats and oxygen glucose deprivation/reoxygenation (OGD/R)-induced cardiac myocytes (CMs). In vitro, our data show that certain dose of SQLXF inhibited OGD/R-induced CMs apoptosis, cell viability decreasing and oxidative stress. Conclusion Overall, certain dose of SQLXF could effectively improve the cardiac function of CHF rats through inhibition of CMs apoptosis via balancing mitochondrial fission and fusion. Our data proved a novel action mechanism of SQLXF in CHF improvement, and provided a reference for clinical.

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Shen Qi Wan ameliorates nephritis in chronic kidney disease via AQP1 and DEFB1 regulation

Liu,

Hong,

Liu

et al. 2024

Biomedicine & Pharmacotherapy

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The Effect of Shen Qi Wan Medicated Serum on NRK-52E Cells Proliferation and Migration by Targeting Aquaporin 1 (AQP1)

Cited by 3 publications

References 32 publications

Potential Therapeutic Properties of the Leaf of Cydonia Oblonga Mill. Based on Mineral and Organic Profiles

Potential Therapeutic Properties of the Leaf of Cydonia Oblonga Mill. Based on Mineral and Organic Profiles

Shen Qi Li Xin formula improves chronic heart failure through balancing mitochondrial fission and fusion via upregulation of PGC-1α

Shen Qi Wan ameliorates nephritis in chronic kidney disease via AQP1 and DEFB1 regulation

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