The effect of shock wave lithotripsy on nitric oxide and malondialdehyde levels in plasma and urine samples

Aksoy, Hülya; Aksoy, Yılmaz; Turhan, Hamdullah; Keleş, Mevlüt Sait; Ziypak, Tevfik; Özbey, İsa

doi:10.1002/cbf.1349

Cited by 19 publications

(16 citation statements)

References 18 publications

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“…In our study, eNOS was significantly up-regulated 1 d after ESWA. The observation of increased eNOS levels after ESWA is in line with findings of other researchers [41][42][43]. In addition, we observed a significantly increased expression of vWF within the endothelial lining.…”

Section: U N C O R R E C T E D P R O O Fsupporting

confidence: 93%

Microvascular Response to Shock Wave Application in Striated Skin Muscle

Calcagni

Chen

Högger

et al. 2011

Journal of Surgical Research

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Background: This study aims to quantify by intravital microscopy the microhemodynamic response after extracorporeal shock wave application (ESWA) to the physiologic microcirculation of the mouse dorsal skinfold chamber.Materials and Methods: ESWA was carried out using an electrohydraulic shock wave source. Two different shock wave doses of 500 and 1000 pulses at an energy flux rate of 0.08 mJ/mm2 and a frequency of 4 Hz were compared with sham-operated animals. Microcirculatory analyses were performed at baseline (BL) and during a 3 d observation period after ESWA. The expression of caspase-3 (casp-3), proliferating cell nuclear antibody (PCNA), von Willebrand factor (vWF), and endothelial nitric oxide synthase (eNOS) were analyzed semiquantitatively by immunohistochemistry.Results: ESWA provoked a significant and persistent increase of functional capillary density (FCD) throughout the observation period, reaching a maximum (140% ± 5% of BL, P < 0.05 versus sham) after 1 d when animals were treated with 1000 pulses. ESWA induced a slight increase of leukocyte rolling (not, vert, similar2-to not, vert, similar3.5-fold, P < 0.05) and leukocyte adherence (not, vert, similar1.5-to not, vert, similar2-fold, P < 0.05) to the endothelial lining of postcapillary venules. One day following ESWA, we observed enhanced expression of casp-3 (not, vert, similar3-to not, vert, similar4-fold), PCNA (not, vert, similar9-to not, vert, similar14-fold), vWF (not, vert, similar11-to not, vert, similar14-fold), and eNOS (not, vert, similar3-fold), all P < 0.05.Conclusion: This study shows that ESWA provokes a favorable persistent increase of patent capillaries, however accompanied by a transient and slight inflammatory response but also by dose-dependant apoptotic cell death. Our data suggest that ESWA might represent a noninvasive biomechanical tool to treat critically perfused and endangered tissues, but certainly warrants further investigation. Background. This study aims to quantify by intravital microscopy the microhemodynamic response after extracorporeal shock wave application (ESWA) to the physiologic microcirculation of the mouse dorsal skinfold chamber. U N C O R R E C T E D P R O O FMaterials and Methods. ESWA was carried out using an electrohydraulic shock wave source. Two different shock wave doses of 500 and 1000 pulses at an energy flux rate of 0.08 mJ/mm 2 and a frequency of 4 Hz were compared with sham-operated animals. Microcirculatory analyses were performed at baseline (BL) and during a 3 d observation period after ESWA. The expression of caspase-3 (casp-3), proliferating cell nuclear antibody (PCNA), von Willebrand factor (vWF), and endothelial nitric oxide synthase (eNOS) were analyzed semiquantitatively by immunohistochemistry.Results. ESWA provoked a significant and persistent increase of functional capillary density (FCD) throughout the observation period, reaching a maximum (140% ± 5% of BL, P < 0.05 versus sham) after 1 d when animals were treated with 1000 pulses. ESWA induced a slight increase of ...

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Section: U N C O R R E C T E D P R O O Fsupporting

confidence: 93%

Microvascular Response to Shock Wave Application in Striated Skin Muscle

Calcagni

Chen

Högger

et al. 2011

Journal of Surgical Research

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“…Bomanji et al [32] reported a decrease in renal perfusion after ESWL that was associated with the production of different OFRs. Aksoy et al [5] reported an increase in MDA and nitric oxide in plasma and urine immediately after a shockwave session. However, as in the present study, neither a study by Clark et al [33] nor a previous study [34] found changes in LPO levels.…”

Section: Eswl Associated Injurymentioning

confidence: 99%

“…The decrease in cytokines seen after administration (9) 70 (60) (4) (11) 150 (150) (9) 50 (80) (12) PG 90 (130) 120 (140) 210 (240) (5) 290 (220) (6) 80 (100) (7) β2-microglobulin, μg/L CoQ10 1904.67 (1120) 1480.9 (265) (2) (10) 1504 (569) (9) 1643 ( …”

Section: Effect Of Coq10 On Interleukinsmentioning

confidence: 99%

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

et al. 2014

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These results are protected by a patent at the Spanish Office of Patents and Trademarks (Reference: P201131992) Objective• To determine the efficacy of coenzyme Q10 (CoQ10) in preventing renal injury in patients with lithiasis undergoing extracorporeal shockwave lithotripsy (ESWL). Patients and Methods• Prospective, randomised, double-blind, placebo-controlled clinical trial of 100 patients with renal lithiasis who were treated with ESWL.• The patients were distributed randomly into two groups receiving either placebo or CoQ10 (200 mg/day), a powerful antioxidant with vasoactive properties, orally administered during the week before ESWL and for 1 week after.• Renal dysfunction markers, vasoactive hormones, oxidative stress, plasma levels of several interleukins and vascular resistance index (VRI) using Doppler ultrasound were evaluated the week before ESWL, 2 h before ESWL and at 2 h, 24 h and 7 days after ESWL. Results• There was a significant increase in glomerular filtration (P = 0.013), as well as a decrease in the albumin/creatinine ratio and the β2-microglobulin level (P = 0.02) after 1 week of treatment in the CoQ10 group. These changes were maintained at the follow-up after ESWL.• The administration of CoQ10 was associated with improvement in vasoactive hormone parameters, VRI and interleukin levels. These improvements were maintained until the end of the follow-up period.• However, the administration of CoQ10 was not associated with significant changes in the oxidative stress parameters. Conclusion• Our results indicate that CoQ10 administration improves renal function and vasoactive and inflammation parameter values, allowing for preconditioning before the tissue insult caused by ESWL.

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“…One of the possible mechanisms for SWL-related renal damage is increased oxidative stress due to renal ischemia-reperfusion injury (3,4,5). An experimental model on rabbits demonstrated a statistically significant decrease in tissue scavenger enzyme levels (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, long-term tissue effects of SWL are needed to be investigated despite its long-term proven efficacy. There have been several reports proposing that SWL causes oxidative stress due to renal ischemia-reperfusion injury (3,4,5). Furthermore, some agents have been tested to prevent SWL-induced renal oxidative stress (6,7).…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of N-acetylcysteine Against Renal Oxidative Stress After Extracorporeal Shock Wave Treatment: An Experimental Rat Model

Baba¹,

Çam²,

Şenoğlu³

et al. 2020

jus

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To evaluate effects of renal extracorporeal shock wave lithotripsy (SWL) on plasma Oxidative Stress index (OSI) and to observe histopathological alterations in an experimental model. Secondly, protective role of N-acetylcysteine (NAC) was investigated. Materials and Methods: A total of 24 rats were randomly divided into 3 groups as control (group 1), SWL + saline (group 2), and SWL + NAC (group 3). Study groups were further divided into two subgroups as short-term and long-term. In groups 2 and 3, 2000 shock waves were applied. Intraperitoneal saline was administered in group 2, and intraperitoneal NAC was given to group 3. No treatment was administered to group 1. Blood samples and nephrectomy specimens were obtained for biochemical and histopathological examinations, respectively. OSI was calculated by measuring plasma total antioxidant status (TAS) and total oxidant status (TOS). Acute and chronic histopathological damage were evaluated by light microscopy. Results: SWL caused a remarkable increase in oxidative stress. Strikingly, TOS levels were significantly lower (p=0.027) and TAS levels were significantly higher (p=0.006) in rats with SWL + NAC (group 3). As a result, OSI was lower (p=0.013). This effect was particularly significant in the short-term subgroup. It was also concluded that tubular damage and interstitial inflammation were higher in the SWL group (p=0.022). These acute histological alterations were slighter in rats with NAC. Conclusion: The current study demonstrated that SWL can cause severe oxidative stress and acute renal damage by increasing free oxygen radical production. NAC was effective in decreasing SWL-induced oxidative stress and preventing certain histological alterations to some extent.

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The effect of shock wave lithotripsy on nitric oxide and malondialdehyde levels in plasma and urine samples

Cited by 19 publications

References 18 publications

Microvascular Response to Shock Wave Application in Striated Skin Muscle

Microvascular Response to Shock Wave Application in Striated Skin Muscle

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

The Efficacy of N-acetylcysteine Against Renal Oxidative Stress After Extracorporeal Shock Wave Treatment: An Experimental Rat Model

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