The Effect of Short Term Starvation on the Plasma Kinetics of Sulphadimidine in Rabbits

., E.U. Etuk; Umarudeen, A. M.; Onyeyili, P. A.; Elsa, A. T.

doi:10.3923/ijp.2006.331.334

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…This agrees with the report of Wang et al (2006) indicating that starved animals adapt their biochemical and physiological processes to reduce metabolism. The present finding is at variance with the report of Etuk et al (2006) indicating that rabbit has higher elimination rate constant (0.010-0.23/hr) in comparison with turkeys (0.002-0.01/hr) which may be due to differences in the route of administration, mode of metabolism and elimination. Higher elimination half-life of sulphadimidine in starved turkeys may also pose risk of environmental contamination, especially when droppings from turkeys administered sulphadimidine is used as organic manure.…”

Section: Discussioncontrasting

confidence: 83%

“…In Australia the minimum residue limit (MRL) of sulphonamide in turkey is 0.2 ppm (NRAAVCA, 2000), while in Europe the MRL of sulphonamide in most edible tissues is 0.1 ppm (Council Regulation, 1990). But the tissue residue of sulphadimidine in liver, kidney, pectoral muscle, heart and brain of rabbit were undetectable after 12days of administration (Etuk et al, 2006). In pig the tissue residue of sulphadimidine was depleted to <0.1 ppm in 4 days and 8 -10 days in liver and kidney respectively (Duffee et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

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Tissue distribution of sulphadimidine sodium in non-starved and starved grower turkeys (meleagris gallopavo)

Agbo

Saganuwan

Azubuike

2016

IJPT

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Background: The use of veterinary drugs in food-producing animals has potential to generate residues in edible tissues and posses health hazard to consumers especially when the withdrawal period is not observed. Objectives: The study was conducted to determine the tissue residue and withdrawal period of sulphadimidine in non-starved and starved grower turkeys following a single intramuscular administration. Methods: Forty two turkeys of both sexes and 12 weeks old weighing 1.57±0.2 kg were divided into two groups of twenty one each. One group was administered a single intramuscular dose of sulphadimidine sodium (100mg/kg body weight). The other group was kept off-feed for 48 hours before drug administration. Three turkeys each were sacrificed from the starved and non-starved group and two grammes (2g) of tissue sample were harvested from selected tissues. Results:The results showed that the drug residues persisted in all the tissues of turkeys sampled for up to thirty (30) days after drug administration. The starved turkeys maintained consistently higher concentrations of the drug in the tissues than fed ones. Sulphadimidine residue was significantly increased (p<0.05) between days 3 to 6 in the spleen of non-starved turkeys. However, the concentrations in the spleen decreased significantly (p<0.05) between days 6 to 10 and 25 to 30. Conclusion: Sulphadimidine residue persisted in the tissues of non-starved and starved turkeys for up to 30 days after intramuscular injection. This should be given due consideration in the estimation of the withdrawal period for the drug, since sulphadimidine residue in meat > 0.2 ppm is unsafe for human consumption.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Tissue distribution of sulphadimidine sodium in non-starved and starved grower turkeys (meleagris gallopavo)

Agbo

Saganuwan

Azubuike

2016

IJPT

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“…44 Lack of difference in the half-life and elimination rate constant between residue of sulfadimidine in sulfadimidine and sulfadimidine/piroxicam injected WAD goats shows that piroxicam does not affect half-life and elimination rate constant of tissue residue of sulfadimidine in the goats. But our present finding is at variance with the report indicating that rabbit has higher elimination rate constant (0.010-0.23 h) 43 in comparison with turkeys 0.002-0.001 h 45 and WAD goats (0.00058-0.00149 h) signifying difference in the route of administration, mode of metabolism, drug interaction, and elimination. Higher elimination half-life of sulfadimidine in WAD goats may also pose risk of environmental contamination, most especially, when droppings from goats administered sulfadimidine are used as organic manure.…”

Section: Discussioncontrasting

confidence: 92%

“…41 In sheep, sulfadimidine residue was detected at the level <0.14 ppm after 3.5 days. 42 In the present study, the half-life of sulfadimidine residues in the affected organs is 470.35-1700.79 h. This is at variance with the report indicating that the tissue half-life was between 5.63 and 16.31 h. 43 This may be due to the difference in the route of administration. However, the most obvious reason for unacceptable residues might be due to the failure to keep the withdrawal period including using overdose and long-acting drugs.…”

Section: Discussioncontrasting

confidence: 72%

Effects of piroxicam on tissue distribution of sulfadimidine in West African Dwarf male and female goats

2017

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Cases of Stevens-Johnson syndrome have been increasingly reported in Nigeria by individuals who consumed meat products of animals especially goats injected sulfonamides. Hence, tissue distribution and residues of intramuscular sulfadimidine were studied in West African Dwarf (WAD) goats. Twenty goats divided into two groups of 10 each (five males; five females) weighing 10.4 ± 1.63 kg were administered intramuscular sulfadimidine (100 mg/kg body weight), and the second group was coadministered 5 mg/kg of piroxicam via right and left thigh muscle, respectively. Samples of the liver, kidney, spleen, heart, lung, intestine, brain, and skeletal muscle were collected into sterile cellophane bags. Two untreated goats were killed and used for preparation of tissue standards. The tissue samples were stored frozen for analysis. High concentration of sulfadimidine residues was found in all the tissues of goats administered sulfadimidine as well as tissues of goats coadministered sulfadimidine/piroxicam for up to 30 days postdrug administration. Generally, residues of sulfadimidine were observed to be significantly higher than the acceptable limit (0.1 ppm). Hence, consumption of meats from WAD goats administered sulfadimidine may pose very high risk of Stevens-Johnson syndrome in sensitive humans. As such consumption of such meats should be avoided.

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“…As a result, starvation can potentially exert an influence on drug pharmacokinetics (PK) (Anderson, 1988;Karimi et al, 2021;Krishnaswamy, 1978;Lammers et al, 2020). In fact, starvation-induced PK changes have been reported in many land animals such as turkey (Agbo et al, 2016), rabbit (Etuk et al, 2006), goat (Abdullah & Baggot, 1986, 1988, calve (Janus et al, 1997(Janus et al, , 2001(Janus et al, , 2003, and rat (Nakashima et al, 1987); the most consistent findings from these studies are prolonged drug elimination rates in the starved animals. Unfortunately, to the best of the author's knowledge, no similar information is available in any fish species.…”

Section: Introductionmentioning

confidence: 87%

Effects of starvation on the pharmacokinetics and optimal dosages of florfenicol and associated serum biochemistry in Asian seabass (Lates calcarifer)

Rairat

Hsieh

et al. 2023

Vet Pharm & Therapeutics

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Starvation has influence on physiology and pharmacokinetic (PK) characteristics of many drugs in land animals. However, similar PK information in fish is lacking. The current study examined the effects of starvation on fish PK, taking florfenicol (FF) in Asian seabass as an example. FF was orally administered at a single dose of 10 mg/kg into 35‐day starved fish reared at 25 and 30°C and the serum FF concentration was analyzed by HPLC‐FLD. At 30°C, the absorption and elimination half‐lives of the starved fish were increased by 30% (from 0.44 to 0.57 h) and 55% (from 7.2 to 11.18 h), respectively. The volume of distribution, clearance, and area under the curve were changed from 1.25 to 0.71 L/kg, 0.120 to 0.044 L/kg/h, and 88 to 228 h·μg/ml, respectively. Similar starvation‐induced PK changes were also observed at 25°C. The serum biochemical parameters, mainly the alanine aminotransferase, aspartate aminotransferase, and glucose levels, were significantly reduced in the starvation group. Overall, FF absorption, distribution, and elimination rates were reduced by starvation, resulting in four to five times lower optimal dosage than the non‐starved fish. Drug treatment in starved fish should be treated with caution as overdosing and/or tissue residues could perceivably occur.

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The Effect of Short Term Starvation on the Plasma Kinetics of Sulphadimidine in Rabbits

Cited by 6 publications

References 5 publications

Tissue distribution of sulphadimidine sodium in non-starved and starved grower turkeys (meleagris gallopavo)

Tissue distribution of sulphadimidine sodium in non-starved and starved grower turkeys (meleagris gallopavo)

Effects of piroxicam on tissue distribution of sulfadimidine in West African Dwarf male and female goats

Effects of starvation on the pharmacokinetics and optimal dosages of florfenicol and associated serum biochemistry in Asian seabass (Lates calcarifer)

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