The Effect of Short-Term Cardiac Rehabilitation After Acute Myocardial Infarction on High-Sensitivity C-Reactive Protein

Mlakar, Polona; Salobir, Barbara; Čobo, Nusret; Jug, Borut; Terčelj, Marjeta; Šabovič, Mišo

doi:10.1089/met.2013.0038

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…reported that a four-week CR program could significantly reduce hs-CRP levels among STEMI patients, from 3.1 mg/L to 2.1 mg/L ( P < 0.0001) [13]. In 2014, a study conducted in Slovenia found that patients with acute MI had higher baseline levels of hs-CRP than healthy individuals; while, after a 2-week CR was applied, hs-CRP significantly diminished in the non-smokers ( P < 0.006), but not among the smoker patients [14]. A recent study in Romania showed that CR is as much effective as statins in reducing the hs-CRP levels among acute MI patients [15].…”

Section: Discussionmentioning

confidence: 99%

Effects of cardiac rehabilitation on inflammatory biomarkers in unstable ischemic heart disease patients following percutaneous coronary intervention: a randomized controlled study

Awada,

Sanaei,

Jameie

et al. 2023

Coronary Artery Disease

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Introduction Several blood inflammatory markers, such as high-sensitivity C-reactive protein (hs-CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), are linked to increased risk for cardiovascular diseases. This study aimed to evaluate these inflammatory markers after cardiac rehabilitation (CR) in patients with unstable ischemic heart disease (UIHD) who underwent successful percutaneous coronary intervention (PCI). Methods A cohort of 115 patients with successful PCI due to UIHD enrolled in the study from January 2018 to March 2021. We used a permuted block stratified randomization technique (2 : 1 ratio). Seventy-seven patients were randomized to the CR group and 38 patients to the control group. The CR group underwent a 12-week pre-specified CR regimen. Blood samples were taken at baseline and follow-up at 12 weeks for both groups. Result Among the 115 patients, 33 patients were female. The mean age was (53 ± 5.55 years) in the control and (53 ± 6.09 years) in the CR group. The two groups were comparable regarding their baseline characteristics and the values of the inflammatory markers. By contrast, at 12 weeks, the inflammatory marker values were significantly lower in the CR group compared to the control group; hs-CRP: 0.11 [0.08–0.14] vs. 0.21 [0.19–0.21], P-value <0.001; NLR: 2.17 [1.42–2.43] vs. 2.26 [2.07–2.6], P-value: 0.016; PLR: 91.2821 [63.3333–103.2000] vs. 92.600 [84.6154–110.0000], P-value: 0.027. Conclusion CR after PCI in UIHD patients may attenuate some inflammatory markers, which might benefit cardiovascular health. Further studies are required to evaluate these findings with longer follow-up and the powered to measure major cardiovascular event rates.

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Section: Discussionmentioning

confidence: 99%

Effects of cardiac rehabilitation on inflammatory biomarkers in unstable ischemic heart disease patients following percutaneous coronary intervention: a randomized controlled study

Awada,

Sanaei,

Jameie

et al. 2023

Coronary Artery Disease

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“…Nuestros pacientes tuvieron una tasa má s alta de abstinencia de tabaco que en estudios previos independientemente del grupo asignado. Esto es muy relevante, ya que los beneficios de muchos tratamientos podrían reducirse o incluso quedar suprimidos en los fumadores persistentes 13,14 .…”

Section: Discusió Nunclassified

“…realizar PRC adaptados a estos pacientes. En esta línea, algunos estudios que evaluaron la conveniencia de PRC de 2 semanas de duració n mostraron solo una mejora de la capacidad de ejercicio y variables sustitutivas, como el estré s oxidativo o marcadores inflamatorios, aunque sin comparar directamente sus resultados con los de programas tradicionales de mayor duració n [13][14][15] .…”

Section: Introduccionunclassified

Factibilidad y resultados de un programa de rehabilitación cardiaca intensiva. Perspectiva del estudio aleatorizado MxM (Más por Menos)

Castro-Conde

Abeytua

Esteban

et al. 2021

Revista Española de Cardiología

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Introduccio´n y objetivos: Los programas de rehabilitació n cardiaca (PRC) engloban intervenciones encaminadas a mejorar el pronó stico de la enfermedad cardiovascular influyendo en la condició n física, mental y social de los pacientes, pero no se conoce su duració n ó ptima. Nuestro objetivo es comparar los resultados de un PRC está ndar frente a otro intensivo má s breve tras un síndrome coronario agudo, mediante el estudio Má s por Menos. Me´todos: Diseñ o prospectivo, aleatorizado, abierto, enmascarado a los evaluadores de eventos y multicé ntrico (PROBE). Se aleatorizó a los pacientes al PRC está ndar de 8 semanas u otro intensivo de 2 semanas con sesiones de refuerzo. Se realizó una visita final 12 meses despué s, tras la finalizació n del programa. Se evaluó : adherencia a la dieta, esfera psicoló gica, há bito tabá quico, tratamiento farmacoló gico, capacidad funcional, calidad de vida, pará metros cardiometabó licos y antropomé tricos, eventos cardiovasculares y mortalidad por cualquier causa durante el seguimiento. Resultados: Se analizó a 497 pacientes (media de edad, 57,8 AE 10,0 añ os; el 87,3% varones; programa intensivo, n = 262; está ndar, n = 235). Las características basales de ambos grupos eran similares. Al añ o, má s del 93% había mejorado en al menos 1 MET el resultado de la ergometría. Ademá s, la adherencia a la dieta mediterrá nea y la calidad de vida mejoraron significativamente con el PRC, sin diferencias significativas entre grupos. Los eventos cardiovasculares ocurrieron de manera similar en ambos grupos. Conclusiones: La PRC intensiva podría ser tan efectiva como la PRC está ndar en lograr la adherencia a las medidas de prevenció n secundaria y ser una alternativa para algunos pacientes y centros.Registrado en ClinicalTrials.gov (identificador: NCT02619422).

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The Effects of Exercise on Cardiovascular Biomarkers: New Insights, Recent Data, and Applications

Che

Liu

2017

Advances in Experimental Medicine and Biology

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The benefit of regular exercise or physical activity with appropriate intensity on improving cardiopulmonary function and endurance has long been accepted with less controversy. The challenge remains, however, quantitatively evaluate the effect of exercise on cardiovascular health due in part to the amount and intensity of exercise varies widely plus lack of effective, robust and efficient biomarker evaluation systems. Better evaluating the overall function of biomarker and validate biomarkers utility in cardiovascular health should improve the evidence regarding the benefit or the effect of exercise or physical activity on cardiovascular health, in turn increasing the efficiency of the biomarker on individuals with mild to moderate cardiovascular risk. In this review, beyond traditional cytokines, chemokines and inflammatory factors, we systemic reviewed the latest novel biomarkers in metabolomics, genomics, proteomics, and molecular imaging mainly focus on heart health, as well as cardiovascular diseases such as atherosclerosis and ischemic heart disease. Furthermore, we highlight the state-of-the-art biomarker developing techniques and its application in the field of heart health. Finally, we discuss the clinical relevance of physical activity and exercise on key biomarkers in molecular basis and practical considerations.

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The Effect of Short-Term Cardiac Rehabilitation After Acute Myocardial Infarction on High-Sensitivity C-Reactive Protein

Cited by 5 publications

References 28 publications

Effects of cardiac rehabilitation on inflammatory biomarkers in unstable ischemic heart disease patients following percutaneous coronary intervention: a randomized controlled study

Effects of cardiac rehabilitation on inflammatory biomarkers in unstable ischemic heart disease patients following percutaneous coronary intervention: a randomized controlled study

Factibilidad y resultados de un programa de rehabilitación cardiaca intensiva. Perspectiva del estudio aleatorizado MxM (Más por Menos)

The Effects of Exercise on Cardiovascular Biomarkers: New Insights, Recent Data, and Applications

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