The effect of short-term vitamin E against radioiodine-induced early lacrimal gland damage

Acar, Uğur; Atilgan, Hasan Ikbal; Acar, Damla Ergintürk; Yalnız-Akkaya, Züleyha; Yumuşak, Nihat; Korkmaz, Meliha; Koca, Gökhan

doi:10.1007/s12149-013-0763-z

Cited by 16 publications

(11 citation statements)

References 20 publications

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“…Upadhyaya et al (15) detected the protective effect of vitamin E against the radio-iodine-induced damage in salivary glands. Acar et al (13) proposed the anti-infl ammatory and anti-fi brotic effect of vitamin E against the damage in lacrimal glands of RAI-administered rats. In a study by Ramos et al (24) the protective effect of vitamin E in single dose radiation-applied rats was detected by measuring the volume of saliva.…”

Section: Discussionmentioning

confidence: 99%

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Beneficial effects of vitamin E on radioiodine induced gastrointestinal damage: an experimental and pathomorphological study

Yumuşak¹,

Sadic²,

Akbulut³

et al. 2019

BLL

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The aim of the present study was to investigate the radioprotective effect of vitamin E in the prevention of radioiodine (RAI) induced gastrointestinal damage. METHOD: Twenty-four rats were randomly divided into three groups as follows: Group-1 was untreated control group, Group-2 was orally administered single dose of 111 MBq RAI, and Group-3 was orally administered 111 MBq RAI and 1 mL of oral vitamin E. Vitamin E was started two days before RAI administration and was continued for fi ve days once daily after RAI. Pathomorphological parameters of gastrointestinal tissues (stomach, small intestines and bowels) were measured using Hematoxylin-Eosin and Masson's trichrome staining. RESULTS: Varying degrees of infl ammation, edema, ulcer, mucosal degeneration, necrosis and fi brosis were seen in the stomach, small intestine and bowel tissues of the rats in both study groups and not in the control group. The differences were statistically signifi cant between these groups for all parameters (p < 0.05). The histopathological damage in the vitamin E treated group was signifi cantly less than the damage in the RAI only group (p < 0.05 for all pathomorphological parameters). CONCLUSION: The results of this study showed that vitamin E has a radioprotective property with antiinfl ammatory and antifi brotic effects protecting against gastrointestinal damage caused by radioiodine (Tab.

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Section: Discussionmentioning

confidence: 99%

“…Vitamin E, which is non-toxic, has been used in the treatment of diseases such as cataract, cancer and cardiovascular diseases (12). Recent studies have revealed that vitamin E has a radio-protective effect against lacrimal and salivary gland damage which occurs in patients receiving RAI treatment (13,14,15).…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of vitamin E on radioiodine induced gastrointestinal damage: an experimental and pathomorphological study

Yumuşak¹,

Sadic²,

Akbulut³

et al. 2019

BLL

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“…However, these findings demonstrate the importance of alerting health professionals and patients to the possibility of occurrence of these events for early diagnosis and treatment. Although there is no effective method to prevent the adverse effects of radioiodine therapy on the lacrimal system, the use of antioxidants, such as vitamin E, lycopene, and montelukast, or NIS blockers, such as perchlorate, are potential therapeutic options.…”

Section: Discussionmentioning

confidence: 99%

“…However, these findings demonstrate the importance of alerting health professionals and patients to the possibility of occurrence of these events for early diagnosis and treatment. Although there is no effective method to prevent the adverse effects of radioiodine therapy on the lacrimal system, the use of antioxidants, such as vitamin E, 56 lycopene, 57 and 59 are potential therapeutic options. Prospective studies with a larger sample size and longer follow-up are essential to determine the measures of association, including the relative risk of ocular and nasal adverse effects in patients treated with radioiodine therapy.…”

Section: Discussionmentioning

confidence: 99%

Correlation among ocular surface disease, xerostomia, and nasal symptoms in patients with differentiated thyroid carcinoma subjected to radioiodine therapy: A prospective comparative study

et al. 2017

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“…Koca et al (17) recently showed that RAI treatment causes morphological damage to rat lacrimal glands, and montelukast sodium effectively protects lacrimal glands against the damage of the treatment. Acar et al (1) described RAI-induced changes in rat lacrimal glands after oral RAI administration and the effect of vitamin E in preventing these probable changes. According to the results of the current study, histopathological examinations revealed that ML protects rat liver against radioiodine related liver damage.…”

Section: Discussionmentioning

confidence: 99%

Radioprotective effect of montelukast sodium against hepatic radioiodine (131I) toxicity: A histopathological investigation in the rat model

Atilgan¹,

Yumuşak²,

Sadic³

et al. 2015

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary: Radioactive iodine (131 I) is a known radionuclide which is used both for diagnostic and therapeutic purposes in the treatment of hyperthyroidism and thyroid cancer. Montelukast sodium (Cysteinyl leukotriene receptor-1 antagonist) is also a wellknown antioxidant drug. This study aimed to evaluate the histopathological changes in rat livers at the third month following 131 I treatment and the radioprotective effect of Montelukast sodium (ML) against 131 I-related liver damage. Thirty female Wistar Albino rats were randomly divided into three groups as control group (n=10), untreated rats; second (RAI) group (n=10), oral radioiodine (111 MBq) administrated rats, and third (ML) group (n=10), oral radioiodine and ML administrated rats. In the third group, ML administration was started 3 days before and ended 10 days after RAI administration. In the third month of radioiodine (RAI) administration, the animals were decapitated and the livers were removed for histopathological examination. The histopathologic data were evaluated comparatively by using Mann Whitney U and Fisher's Exact Tests Differences were determined in all the parameters in terms of intensity between the control and 131 I groups, which showed the harmful effects of 131 I. In the comparison of the 131 I and ML groups, hyperemia was determined respectively 80% to 40%, the presence of inflammatory cells 70% to 60% and capsule thickening 70% to 40%. Montelukast sodium was observed to have a protective effect especially on hyperemia and capsule thickening. According to the study results, radioactive iodine ( 131 I) treatment seems to cause morphological damage to the rat liver, and Montelukast sodium effectively protects the liver against damage.Key words: Iodine-131, histopathology, liver, montelukast sodium, rat. Karaciğerde radyoiodin ( 131 İ) toksisitesine karşı montelukast sodyumun radyoprotektif etkisi: Rat modelinde histopatolojik incelemelerÖzet: Radyoaktif iyot ( 131 I) hipertiroidizm ve tiroid kanserlerinin tanı ve tedavisi amacıyla kullanılan bir radyonükliddir. Montelukast sodyum (Cysteinyl leukotriene receptor-1 inhibitörü) ise antioksidan olarak bilinen bir ilaçtır. Bu çalışma ile rat karaciğerinde radyoiodinden (RAI) kaynaklanan radyasyon hasarına karşı Montelukast sodyumun (ML) radyoprotektif etkisinin histopatolojik olarak değerlendirilmesi amaçlandı. Çalışmada 30 adet dişi Wistar Albino rat kullanıldı ve bunlar rastgele üç gruba ayrıldı; birinci grubu hiçbir işleme tabi tutulmayan kontrol grubu (n=10), ikinci (RAI) grubu, (n=10), oral olarak RAI (111 MBq) uygulanan ratlar, üçüncü (ML) grubunu ise (n=10) oral olarak RAI ve ML uygulanan grup oluşturdu. Üçüncü çalışma grubunda ML uygulaması RAI uygulamasından 3 gün önce başlatıldı ve 10 gün sonra bitirildi. Üçüncü ay sonunda nekropsileri yapılan ratların karaciğer doku örnekleri rutin doku takibine alınarak histopatolojik olarak incelendi. Radyoiodin ve ML grubunda tüm histopatolojik bulgular Mann Whitney U testi ve Fisher'in ekzak test ile karşılaştırılarak değerlendirildi. Bütün ...

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The effect of short-term vitamin E against radioiodine-induced early lacrimal gland damage

Abstract: According to study results, histopathological examinations revealed that vitamin E protects rat lacrimal glands against RAI-related early damage.

Cited by 16 publications

References 20 publications

Beneficial effects of vitamin E on radioiodine induced gastrointestinal damage: an experimental and pathomorphological study

Beneficial effects of vitamin E on radioiodine induced gastrointestinal damage: an experimental and pathomorphological study

Correlation among ocular surface disease, xerostomia, and nasal symptoms in patients with differentiated thyroid carcinoma subjected to radioiodine therapy: A prospective comparative study

Radioprotective effect of montelukast sodium against hepatic radioiodine (131I) toxicity: A histopathological investigation in the rat model

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