The effect of sibutramine therapy on occurrence of depression symptoms among obese patients

Slováček, Ladislav; Pavlík, Vladimír; Slováčková, Birgita

doi:10.1016/j.numecd.2008.04.002

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…However, it is proven to be successful only in a small minority of the population [4, 5]. Drugs that are currently available for the management of obesity, include orlistat (Xenical) which reduces intestinal fat absorption through inhibition of pancreatic lipase and sibutramine (Reductil), and appetite suppressant [2] which was found to cause numerous side-effects which include valvular heart disease, high blood pressure, dry mouth, constipation, and headache [6]. Multiple risk factor syndrome or metabolic syndrome such as insulin resistance [7], diabetes mellitus [8], cardiovascular disease, stroke, hypertension [9], and dyslipidemia [10] is a growing medical problem in industrialized countries.…”

Section: Introductionmentioning

confidence: 99%

Beta-Glucan-Rich Extract fromPleurotus sajor-caju(Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet

Kanagasabapathy

Malek

Mahmood

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Mushrooms have been used in folk medicine for thousands of years. In this study, the effect of β-glucan-rich extract of P. sajor-caju (GE) on lipid lowering and antioxidant potential was assessed in C57BL/6J mice fed on a high-fat diet. Obesity was induced in C57BL/6J mice by feeding a high-fat diet. The control groups in this study were ND (for normal diet) and HFD (for high-fat diet). The treated groups were ND240 (for normal diet) (240 mg/kg b.w) and HFD60, HFD120, and HFD240 (for high-fat diet), where the mice were administrated with three dosages of GE (60, 120, and 240 mg GE/kg b.w). Metformin (2 mg/kg b.w) served as positive control. GE-treated groups showed significantly reduced body weight, serum lipid, and liver enzymes levels. GE also attenuated protein carbonyl and lipid hydroperoxide levels by increasing the enzymic antioxidants (SOD, CAT, and GPx) activities in the mice. GE-treated groups induced the expression of hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) while downregulated the expression of peroxisome proliferator-activated receptor gamma (PPAR-γ), sterol regulatory binding protein-1c (SREBP-1c), and lipoprotein lipase (LPL). Hence, GE prevented weight gain in the mice by inducing lipolysis and may be valuable in the formulation of adjuvant therapy for obesity.

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Section: Introductionmentioning

confidence: 99%

Beta-Glucan-Rich Extract fromPleurotus sajor-caju(Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet

Kanagasabapathy

Malek

Mahmood

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…However, these agents are known to have undesirable side effects such as high blood pressure, dry mouth, constipation, headache, valvular heart disease and obesity [6]. To date, natural products still play an important role as sources of medicine in preventing diabetes thus, the efforts to discover useful drug candidates to combat diabetic complications are going on relentlessly [7].…”

Section: Introductionmentioning

confidence: 99%

Glucan-rich polysaccharides from Pleurotus sajor-caju (Fr.) Singer prevents glucose intolerance, insulin resistance and inflammation in C57BL/6J mice fed a high-fat diet

Kanagasabapathy

Kuppusamy

Malek

et al. 2012

BMC Complement Altern Med

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BackgroundPleurotus sajor-caju (P. sajor-caju) has been extremely useful in the prevention of diabetes mellitus due to its low fat and high soluble fiber content for thousands of years. Insulin resistance is a key component in the development of diabetes mellitus which is caused by inflammation. In this study, we aimed to investigate the in vivo efficacy of glucan-rich polysaccharide of P. sajor-caju (GE) against diabetes mellitus and inflammation in C57BL/6J mice fed a high-fat diet.MethodsDiabetes was induced in C57BL/6J mice by feeding a high-fat diet. The mice were randomly assigned to 7 groups (n=6 per group). The control groups in this study were ND (for normal diet) and HFD (for high-fat diet). The treated groups were ND240 (for normal diet) (240 mg/kg b.w) and HFD60, HFD120 and HFD240 (for high-fat), where the mice were administrated with three dosages of GE (60, 120, 240 mg GE/kg b.w respectively). Metformin (2 mg/kg b.w) served as positive control. The glucose tolerance test, glucose and insulin levels were measured at the end of 16 weeks. Expressions of genes for inflammatory markers, GLUT-4 and adiponectin in the adipose tissue of the mice were assessed. One-way ANOVA and Duncan’s multiple range tests (DMRT) were used to determine the significant differences between groups.ResultsGE treated groups improved the glucose tolerance, attenuated hyperglycemia and hyperinsulinemia in the mice by up-regulating the adiponectin and GLUT-4 gene expressions. The mice in GE treated groups did not develop insulin resistance. GE also down-regulated the expression of inflammatory markers (IL-6, TNF-α, SAA2, CRP and MCP-1) via attenuation of nuclear transcription factors (NF-κB).ConclusionGlucan-rich polysaccharide of P. sajor-caju can serve as a potential agent for prevention of glucose intolerance, insulin resistance and inflammation.

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“…However, the available synthetic products, such as sibutramine (reductil), which is an appetite suppressant (Tziamalos et al, 2009) have often been associated with undesirable side effects, such as increased blood pressure, constipation, headaches, acute liver failure and insomnia (Slovacek et al, 2008, Thurairajah et al, 2005. Therefore, efforts are being emphasized on the production of functional foods with anti-obesity and anti-hypertensive…”

Section: Introductionmentioning

confidence: 99%

A Review of Potential Marine-derived Hypotensive and Anti-obesity Peptides

Manikkam

Vasiljevic

Donkor

et al. 2015

Critical Reviews in Food Science and Nutrition

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Bioactive peptides are food derived components, usually consisting of 3-20 amino acids, which are inactive when incorporated within their parent protein. Once liberated by enzymatic or chemical hydrolysis, during food processing and gastrointestinal transit, they can potentially provide an array of health benefits to the human body. Owing to an unprecedented increase in the worldwide incidence of obesity and hypertension, medical researchers are focusing on the hypotensive and anti-obesity properties of nutritionally derived bioactive peptides. The role of the renin-angiotensin system has long been established in the aetiology of metabolic diseases and hypertension. Targeting the renin-angiotensin system by inhibiting the activity of angiotensin-converting enzyme (ACE) and preventing the formation of angiotensin II can be a potential therapeutic approach to the treatment of hypertension and obesity. Fish-derived proteins and peptides can potentially be excellent sources of bioactive components, mainly as a source of ACE inhibitors. However, increased use of marine sources, poses an unsustainable burden on particular fish stocks, so, the underutilized fish species and by-products can be exploited for this purpose. This paper provides an overview of the techniques involved in the production, isolation, purification, and characterization of bioactive peptides from marine sources, as well as the evaluation of the ACE inhibitory (ACE-I) activity and bioavailability.

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The effect of sibutramine therapy on occurrence of depression symptoms among obese patients

Cited by 15 publications

References 5 publications

Beta-Glucan-Rich Extract fromPleurotus sajor-caju(Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet

Beta-Glucan-Rich Extract fromPleurotus sajor-caju(Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet

Glucan-rich polysaccharides from Pleurotus sajor-caju (Fr.) Singer prevents glucose intolerance, insulin resistance and inflammation in C57BL/6J mice fed a high-fat diet

A Review of Potential Marine-derived Hypotensive and Anti-obesity Peptides

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