The Effect of Sleep Apnea and Insomnia on Blood Levels of Leptin, Insulin Resistance, IP-10, and Hydrogen Sulfide in Type 2 Diabetic Patients

Jain, Sushil K.; Kahlon, Gunjan; Morehead, Lester; Lieblong, Benjamin J.; Stapleton, Tommie; Hoeldtke, Robert D.; Bass, Pat F.; Levine, Steven N.

doi:10.1089/met.2012.0045

Cited by 37 publications

(27 citation statements)

References 41 publications

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“…Few studies, however, reported the relationships between IP10 and sleep disturbance. Jain et al found that IP10 levels were elevated in type 2 diabetes patients with insomnia, sleep apnea or both [35]. We found that IP10 in healthy menopausal women was significantly related to poor sleep quality as well as low sleep efficiency.…”

Section: Discussionmentioning

confidence: 47%

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Associations of Self-Reported Sleep Quality with Circulating Interferon Gamma-Inducible Protein 10, Interleukin 6, and High-Sensitivity C-Reactive Protein in Healthy Menopausal Women

Huang

Chang

et al. 2017

PLoS ONE

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IntroductionSleep disturbance is very common in menopausal women and poor sleep quality has been linked to systemic inflammation. However, the impact of poor sleep quality on health outcomes of menopausal women remains unclear. This study evaluated the relationships between sleep quality and inflammation in menopausal women.Participants and designThis cross-sectional study enrolled 281 healthy women aged 45 to 60 years. The Pittsburgh Sleep Quality Index (PSQI) was used to measure quality of sleep. Multiplex assays were used to measure the levels of 9 cytokines in morning fasting plasma samples. Other variables measured in this study included clinical characteristics and high-sensitivity C-reactive protein (hs-CRP).SettingThe study was performed at a medical center.ResultsThe 281 participants comprised 79 (28%) perimenopausal women and 202 (72%) postmenopausal women. Global PSQI scores were positively correlated with plasma hs-CRP levels (P = 0.012) and were marginally associated with interferon gamma-inducible protein-10 (IP10), interleukin 6 (IL6), and macrophage inflammatory protein-1beta (MIP-1β) levels. After adjusting for age, body mass index, menopause duration, and follicle stimulating hormone, multiple linear regression analysis revealed that high PSQI scores and sleep efficiency < 65% were associated with elevated plasma levels of hs-CRP, IP10, and IL6. In addition, sleep duration < 5 hours was associated with high hs-CRP levels.ConclusionOur data show that poor sleep quality and low sleep efficiency are associated with elevated levels of circulating inflammatory factors IP10, IL6 and hs-CRP and that short sleep duration is associated with high levels of hs-CRP in menopausal women. These findings provide novel evidence that poor sleep quality is linked to low-grade systemic inflammation in menopausal women.

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Section: Discussionmentioning

confidence: 47%

“…IP10, IL6 and hs-CRP have been demonstrated to be risk factors for metabolic and cardiovascular diseases [35,46,47]. Epidemiological studies consistently demonstrate associations between suboptimal sleep and systemic chronic diseases such as coronary heart disease, stroke, and diabetes [43,48,49].…”

Section: Discussionmentioning

confidence: 99%

Associations of Self-Reported Sleep Quality with Circulating Interferon Gamma-Inducible Protein 10, Interleukin 6, and High-Sensitivity C-Reactive Protein in Healthy Menopausal Women

Huang

Chang

et al. 2017

PLoS ONE

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“…Recent studies report that diabetic patients and diabetic animals also have reduced blood levels of H 2 S [Brancaleone et al, ; Jain et al, ; Whiteman et al, ]. H 2 S is increasingly being recognized as an important signaling molecule and has been shown to modulate a variety of biological effects that may mediate the protection of various organ dysfunctions [Szabó, ; Whiteman et al, ; Jain et al, ; Manna and Jain, ]. Studies in the literature report the protection of pancreatic β‐cells from oxidative stress by H 2 S via an anti‐oxidative mechanism and the activation of AKT signaling [Kaneko et al, ; Taniguchi et al, ].…”

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confidence: 99%

L-cysteine and hydrogen sulfide increase PIP3 and AMPK/PPARγ expression and decrease ROS and vascular inflammation markers in high glucose treated human U937 monocytes

Manna

Jain

2013

J. Cell. Biochem.

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Diabetic patients have lower blood levels of L‐cysteine (LC) and hydrogen sulfide (H2S) and a higher incidence of vascular inflammation. This study examined whether impaired LC or H2S levels affect vascular inflammation markers in diabetes. Human U937 monocytic cells were treated with high‐glucose (HG, 25 mM, 20 h) in the presence or absence of LC (100, 500, or 1,000 µM, an endogenous precursor of H2S) or Na2S (5 or 25 µM, an exogenous source of H2S). Both LC and Na2S supplementation decreased intracellular ROS production and increased cellular PIP3 (phosphatidylinositol‐3,4,5‐trisphosphate) in HG‐exposed cells. The effect of LC on PIP3 was prevented by propargylglycine, an inhibitor of cystathionine‐γ‐lyase (CSE) that catalyzes H2S formation from LC. Signal silencing studies with CSE siRNA also showed the inhibition of H2S formation and PIP3 upregulation in LC‐supplemented CSE knockdown cells exposed to HG. This demonstrates that H2S plays a role in mediating the effect of LC on increased PIP3. Using the PI3K specific inhibitor LY294002, this study demonstrated that PI3K activation mediates the effect of LC and Na2S on PIP3 upregulation. Results showed that supplementation with LC and Na2S reduced NF‐κB phosphorylation and the secretion of TNF‐α, MCP‐1, IL‐8, IL‐1β, and IP‐10. Treatment with LC (500 µM), Na2S (25 µM), and PIP3 (5 nM) increased the AMPK phosphorylation and PPARγ expression in cells exposed to HG. This study reports for the first time a novel molecular mechanism by which Na2S or LC supplementation can lower oxidative stress and various markers of vascular inflammation in diabetes. J. Cell. Biochem. 114: 2334–2345, 2013. © 2013 Wiley Periodicals, Inc.

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“…Separately, although initial insomnia was not significantly associated with incident hypertension, middle insomnia was associated with a 20% increased risk and late insomnia was associated with a 14% increased risk. In addition to hypertension, several studies have shown insomnia to be associated with inflammation (Jain et al, 2012; Laugsand et al, 2012; Motivala, 2011; Okun et al, 2011), impaired heart rate variability (De Zambotti et al, 2011; Israel et al, 2012; Spiegelhalder et al, 2011; Stein & Pu, 2012), and other risk factors (Balbo et al, 2010; Lattova et al, 2011; Laugsand et al, 2013; Strand et al, 2013). …”

Section: Cardiometabolic Disease Risk Associated With Sleep Disturbancementioning

confidence: 99%

Addressing sleep disturbances: An opportunity to prevent cardiometabolic disease?

Grandner

2014

International Review of Psychiatry

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There is increasing awareness of the role of sleep disturbance as an important factor in health and disease. Although subclinical sleep disturbances (insufficient sleep duration or inadequate sleep quality) may be difficult to assess with conceptual and/or methodological clarity, this review attempts to summarize and synthesize these findings. First, the concept of sleep disturbance in a public health context is introduced, to provide context and rationale. Second, operational definitions of ‘cardiometabolic disease’ and ‘sleep disturbance’ are offered, to address many unclear operationalizations. Third, the extant literature is summarized regarding short or long sleep duration and/or insufficient sleep, insomnia and insomnia symptoms, general (non-specific sleep disturbances), circadian rhythm abnormalities that result in sleep disturbances, and, briefly, sleep-disordered breathing. Fourth, the review highlights the social/behavioural context of sleep, including discussions of sleep and race/ethnicity, socio-economic position, and other social/environmental factors, in order to place these findings in a social-environmental context relevant to public health. Fifth, the review highlights the issue of sleep as a domain of health behaviour and addresses issues regarding development of healthy sleep interventions. Finally, a research agenda of future directions is proposed.

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The Effect of Sleep Apnea and Insomnia on Blood Levels of Leptin, Insulin Resistance, IP-10, and Hydrogen Sulfide in Type 2 Diabetic Patients

Cited by 37 publications

References 41 publications

Associations of Self-Reported Sleep Quality with Circulating Interferon Gamma-Inducible Protein 10, Interleukin 6, and High-Sensitivity C-Reactive Protein in Healthy Menopausal Women

Associations of Self-Reported Sleep Quality with Circulating Interferon Gamma-Inducible Protein 10, Interleukin 6, and High-Sensitivity C-Reactive Protein in Healthy Menopausal Women

L-cysteine and hydrogen sulfide increase PIP3 and AMPK/PPARγ expression and decrease ROS and vascular inflammation markers in high glucose treated human U937 monocytes

Addressing sleep disturbances: An opportunity to prevent cardiometabolic disease?

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