The effect of soy nut on serum total antioxidant, endothelial function and cardiovascular risk factors in patients with type 2 diabetes

Sedaghat, Alireza; Shahbazian, Hajieh; Rezazadeh, Afshin; Haidari, Fatemeh; Jahanshahi, Alireza; Latifi, Seyed Mahmoud; Shirbeigi, Esmat

doi:10.1016/j.dsx.2019.01.057

Cited by 21 publications

(25 citation statements)

References 33 publications

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“…However, the role of phenolics in cardiovascular diseases is well substantiated [188]. Supporting the role of legumes in the prevention of CVD, Sedaghat et al [189] carried out a clinical trial and demonstrated that soybean consumption decreased the level of total serum cholesterol and LDL-c in patients with type 2 diabetes. Other clinical trials [190,191] showed similar results with respect to the role of soybean, their products and related phytochemicals in reducing total cholesterol and LDL-c levels, thereby improving the cardiovascular risk profile.…”

Section: Potential Health Benefitsmentioning

confidence: 99%

Is Chickpea a Potential Substitute for Soybean? Phenolic Bioactives and Potential Health Benefits

Camargo

Favero

Morzelle

et al. 2019

IJMS

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Legume seeds are rich sources of protein, fiber, and minerals. In addition, their phenolic compounds as secondary metabolites render health benefits beyond basic nutrition. Lowering apolipoprotein B secretion from HepG2 cells and decreasing the level of low-density lipoprotein (LDL)-cholesterol oxidation are mechanisms related to the prevention of cardiovascular diseases (CVD). Likewise, low-level chronic inflammation and related disorders of the immune system are clinical predictors of cardiovascular pathology. Furthermore, DNA-damage signaling and repair are crucial pathways to the etiology of human cancers. Along CVD and cancer, the prevalence of obesity and diabetes is constantly increasing. Screening the ability of polyphenols in inactivating digestive enzymes is a good option in pre-clinical studies. In addition, in vivo studies support the role of polyphenols in the prevention and/or management of diabetes and obesity. Soybean, a well-recognized source of phenolic isoflavones, exerts health benefits by decreasing oxidative stress and inflammation related to the above-mentioned chronic ailments. Similar to soybeans, chickpeas are good sources of nutrients and phenolic compounds, especially isoflavones. This review summarizes the potential of chickpea as a substitute for soybean in terms of health beneficial outcomes. Therefore, this contribution may guide the industry in manufacturing functional foods and/or ingredients by using an undervalued feedstock.

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Section: Potential Health Benefitsmentioning

confidence: 99%

Is Chickpea a Potential Substitute for Soybean? Phenolic Bioactives and Potential Health Benefits

Camargo

Favero

Morzelle

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…However, direct anti-atherosclerosis activity of preparations based on garlic powder was studied wider than others natural products, their ameliorating effect on the progression of cIMT was proved in randomized double-blinded placebo-controlled trials, registrated on https://clinicaltrials.gov/ (Hodis et al, 2011;Mahdavi-Roshan et al, 2013;Karagodin et al, 2016aKaragodin et al, 2016b. Garlic preparations have the most interesting and obvious cardio-protective properties since garlic is able to ameliorate the blood lipids profile by inhibiting cholesterol biosynthesis, reducing of LDL, modulate arterial hypertension, and inhibit platelet aggregation (Sobenin et al, 2008a;Sobenin et al, 2008b;Sobenin et al, 2009;Jung et al, 2014;Mahdavi-Roshan et al, 2016;Myasoedova et al, 2016;Villa et al, 2017;Choudhary et al, 2018;Sathyapalan et al, 2018;Panahi et al, 2018;Xu et al, 2018;Sedaghat et al, 2019;Adibian et al, 2019;Adab et al, 2019). In laboratory experiments, garlic extract inhibits proliferative and inflammatory cellular reactions, possesses anti-cytokine properties, has pronounced antioxidant activity, so reduces the oxidation of LDL, activates the hydralase of cholesterol esters and inhibit ACAT, so reduces the content of cholesterol esters in cells.…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

et al. 2020

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Atherosclerosis is a chronic multifactorial disease characterized by mainly changes of blood lipids profile and inflammation in vessel wall. The cardiovascular disease based on atherosclerosis is currently the leading cause of mortality in developed countries. Therefore, timely prevention and therapy of atherosclerosis are able to reduce the risk of the development of its clinical manifestations. Anti-atherosclerotic activity of medicinal plants mainly appears in their multiple effects such as anti-inflammatory, antioxidant, antiatherogenic, hypotensive, lipid-lowering, anti-thrombotic. Moreover, most of medicinal plants are characterized by their pleiotropic anti-atherosclerotic action. In addition, the medicinal plants-derived pharmacological substances and/or compounds are characterized by relative safety and fewer side effects that allows considering them as one of potential anti-atherosclerotic effective agents. The direct anti-atherosclerotic effect of some medicinal plants was confirmed in clinical trials of carotid Intima-media thickness (IMT) progression during long-term medication with medicinal plants. This review attempted to determine the current status of the databases PubMed and Scopus (until November, 2019) to investigate the medicinal plants possessing anti-atherosclerotic activity in experimental and clinical studies.

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“… 6 In diabetic neuropathy, the activation of alternative metabolic pathways is strongly associated with intracellular hyperglycemia-induced oxidative stress, 28 and endothelial cells are unable to compensate for increased oxidative stress with nitric oxide production, which may lead to increased oxLDL. 29 , 30 Other investigators have reported that oxLDL-induced activation of NF-κβ attenuates the expression of cell-adhesion molecules (e.g., ICAM-1 and VCAM-1) and provokes inflammation in endothelial cells. 31 These processes in diabetic neuropathy lead to functional changes of the vasa vasorum, thus causing neuronal ischemia and direct axonal damage.…”

Section: Discussionmentioning

confidence: 99%

Effects of alpha-lipoic acid treatment on serum progranulin levels and inflammatory markers in diabetic neuropathy

et al. 2021

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Objectives Progranulin (PGRN) is a secreted growth factor that helps to regulate neuronal survival by blocking tumor necrosis factor-alpha (TNFα) receptors. The antioxidant alpha-lipoic acid (ALA) is used in diabetic neuropathy to improve nerve conduction and relieve neuropathic pain, but its effects on PGRN levels have not yet been elucidated. Methods In this prospective study, 54 patients with type 2 diabetes and peripheral neuropathy received 600 mg of ALA daily for 6 months. Twenty-four patients with diabetes without neuropathy were also included in the study. Serum PGRN and TNFα levels were determined using enzyme-linked immunosorbent assays. In addition, current perception threshold (CPT) testing was used to assess sensory neuropathy. Results After ALA treatment, serum PGRN levels were significantly increased and CPT values were significantly improved. Furthermore, there were significant positive correlations among TNFα, ICAM-1, and PGRN levels both before and after ALA treatment. A significant negative correlation was observed between the improvements in CPT and the PGRN levels. Furthermore, ICAM-1 levels were an independent predictor of PGRN levels. Conclusions Changes in serum PGRN levels indicate that ALA treatment may have beneficial effects on endothelial function and neuronal inflammation.

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The effect of soy nut on serum total antioxidant, endothelial function and cardiovascular risk factors in patients with type 2 diabetes

Cited by 21 publications

References 33 publications

Is Chickpea a Potential Substitute for Soybean? Phenolic Bioactives and Potential Health Benefits

Is Chickpea a Potential Substitute for Soybean? Phenolic Bioactives and Potential Health Benefits

Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

Effects of alpha-lipoic acid treatment on serum progranulin levels and inflammatory markers in diabetic neuropathy

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