The effect of specific gravity of perfluorocarbon liquid on the retina after experimental vitreous substitution

Abstract

Even high purification of PFPH does not prevent retinal damage. The different results in different areas after vitreous substitution with 0.2 cc and with 0.8 cc demonstrate that the high specific gravity of the substance may also play a role in the development of histological changes after extended tamponade.

Effect of gravity in long-term vitreous tamponade: in vivo investigation using perfluorocarbon liquids and semi-fluorinated alkanes

“…In our study a decrease in ERG amplitudes was not detected, indicating that there is no gross damage preventing proper function of the retinal cells. Nevertheless, the ERG as used in this study would be suitable to detect toxic damage of the retina, but functional Retinal damage such as outer and inner photoreceptor damage, thinning of the outer plexiform layer, and epiretinal membrane formation have been at least partially attributed to inflammatory responses [3,4,6,12,[14][15][16][17]. In our study dispersion and fish-egg formation depending on the tamponading agent for time course and extent was seen.…”

“…3a-c). Nuclear counts within the inner nuclear layer in the upper part of the retina did not significantly differ in nonvitrectomized vs. vitrectomized (BSS) eyes (p>0.05: 19.9±4.8 vs. 16 Treated groups did not show evidence of severe structural damage on the light microscopic level. Rarely, a slight disarrangement of the outer nuclear layer was observed, but could not be attributed to a single treatment group.…”

“…These increases in pressure are only a small part of the total intraocular pressure and its diurnal variation [6,21]. Nevertheless, Stolba et al recently demonstrated that filling with either 0.8 cc or 0.2 cc perfluorophenanthrene led to retinal damage depending on the amount of tamponade [16]. The different results in different areas of the retina were interpreted as being related to specific gravity.…”

The concept of heavy tamponades—chances and limitations

“…Stolba et al recently demonstrated that filling with either 0.8 ml or 0.2 ml perfluorophenanthrene led to retinal damage, depending on the amount of tamponade [40]. The different results in different areas of the retina were interpreted as being related to specific gravity.…”

Heavy tamponade 2 Densiron 68® in routine clinical practice: anatomical and functional outcomes of a consecutive case series

“…In rabbit studies, retinal changes were observed after a few weeks and the histological changes were thought to be caused by the weight of PFCL and the effect of their pressure on the retina. 11 So when it came to the design of HSO, consideration was given as to how heavy it should be. The solubility of perfluorohexyloctane (F6H8) is limited, but clearly the more F6H8 is dissolved, the higher the specific gravity.…”