The effect of spin exchange interaction on protein structural stability

Manis‐Levy, Hadar; Schneider, Avi; Tiwari, Satyam; Zer, Hagit; Yochelis, Shira; Goloubinoff, Pierre; Keren, Nir; Paltiel, Yossi

doi:10.1039/d2cp03331c

Cited by 3 publications

(6 citation statements)

References 49 publications

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“…For a bare electrode, electrons with up or down spin would enter at similar rates. However, when the anode is coated with a monolayer of homochiral molecules, the spins of these radicals will preferentially be parallel to each other, due to the CISS effect ( 10 , 11 , 13 , 24 – 26 ). Furthermore, when reactions occur on surfaces, the stability of germinate radical pairs is enhanced ( 52 , 53 ), which works in conjunction with the CISS effect to elongate the lifetime of OH radical pairs on the surface of the chiral electrode.…”

Section: Resultsmentioning

confidence: 99%

“…The role of spin in biological processes is a subject of great interest and scientific debate ( 1 , 2 ). While the role of electron spin in photosynthesis ( 3 – 5 ), magnetoreception ( 6 – 9 ), the chiral-induced spin selectivity (CISS) effect in biology ( 10 – 12 ), and beyond ( 13 – 16 ) has been investigated, the role of the nuclear spin in biological processes is still unclear. With that said, large mass-independent fractionation (MIF) signatures in ions such as Mg 2+ ( 17 ) and Hg 2+ ( 18 , 19 ) have been observed in biological environments.…”

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confidence: 99%

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Nuclear spin effects in biological processes

Vardi,

Maroudas-Sklare,

Kolodny

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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Traditionally, nuclear spin is not considered to affect biological processes. Recently, this has changed as isotopic fractionation that deviates from classical mass dependence was reported both in vitro and in vivo. In these cases, the isotopic effect correlates with the nuclear magnetic spin. Here, we show nuclear spin effects using stable oxygen isotopes ( 16 O, 17 O, and 18 O) in two separate setups: an artificial dioxygen production system and biological aquaporin channels in cells. We observe that oxygen dynamics in chiral environments (in particular its transport) depend on nuclear spin, suggesting future applications for controlled isotope separation to be used, for instance, in NMR. To demonstrate the mechanism behind our findings, we formulate theoretical models based on a nuclear-spin-enhanced switch between electronic spin states. Accounting for the role of nuclear spin in biology can provide insights into the role of quantum effects in living systems and help inspire the development of future biotechnology solutions.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Nuclear spin effects in biological processes

Vardi,

Maroudas-Sklare,

Kolodny

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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“…solution, their denaturation upon addition of urea was examined. 232 The enzymes structural stability was assessed using two methods: bioluminescence measurements, which monitored the activity of the Luciferase enzyme, and fast spectroscopy, which detected the distance between two chromophores implanted at the termini of a barnase core. For both measurements, interactions with magnetic materials altered the structural and functional resiliency of the natively folded proteins, showing greater stability on ferromagnetic surfaces than on paramagnetic surfaces, under mild denaturing conditions.…”

Section: Biological Redox Processesmentioning

confidence: 99%

“…A recent study has examined the importance of spin-exchange interactions on protein stability. After luciferase enzymes were adsorbed onto paramagnetic and ferromagnetic nanoparticles in solution, their denaturation upon addition of urea was examined . The enzymes structural stability was assessed using two methods: bioluminescence measurements, which monitored the activity of the Luciferase enzyme, and fast spectroscopy, which detected the distance between two chromophores implanted at the termini of a barnase core.…”

Section: Prevalence Of Ciss and Ciss Implicationsmentioning

confidence: 99%

“…In what way the resulting spin polarization is affected, however, is hard to define. In other works, studies point to exchange interactions affecting the tilt angle between chiral molecule SAMs and an applied magnetization axis, , the organization of cellulose crystals, and the stability of proteins …”

Section: General Trends and Structure–property Relationshipsmentioning

confidence: 99%

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Chiral Induced Spin Selectivity

Bloom,

Paltiel,

Naaman

et al. 2024

Chem. Rev.

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Since the initial landmark study on the chiral induced spin selectivity (CISS) effect in 1999, considerable experimental and theoretical efforts have been made to understand the physical underpinnings and mechanistic features of this interesting phenomenon. As first formulated, the CISS effect refers to the innate ability of chiral materials to act as spin filters for electron transport; however, more recent experiments demonstrate that displacement currents arising from charge polarization of chiral molecules lead to spin polarization without the need for net charge flow. With its identification of a fundamental connection between chiral symmetry and electron spin in molecules and materials, CISS promises profound and ubiquitous implications for existing technologies and new approaches to answering age old questions, such as the homochiral nature of life. This review begins with a discussion of the different methods for measuring CISS and then provides a comprehensive overview of molecules and materials known to exhibit CISS-based phenomena before proceeding to identify structure−property relations and to delineate the leading theoretical models for the CISS effect. Next, it identifies some implications of CISS in physics, chemistry, and biology. The discussion ends with a critical assessment of the CISS field and some comments on its future outlook.

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Quantum Biology and the Potential Role of Entanglement and Tunneling in Non-Targeted Effects of Ionizing Radiation: A Review and Proposed Model

Matarèse,

Rusin,

Seymour

et al. 2023

IJMS

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It is well established that cells, tissues, and organisms exposed to low doses of ionizing radiation can induce effects in non-irradiated neighbors (non-targeted effects or NTE), but the mechanisms remain unclear. This is especially true of the initial steps leading to the release of signaling molecules contained in exosomes. Voltage-gated ion channels, photon emissions, and calcium fluxes are all involved but the precise sequence of events is not yet known. We identified what may be a quantum entanglement type of effect and this prompted us to consider whether aspects of quantum biology such as tunneling and entanglement may underlie the initial events leading to NTE. We review the field where it may be relevant to ionizing radiation processes. These include NTE, low-dose hyper-radiosensitivity, hormesis, and the adaptive response. Finally, we present a possible quantum biological-based model for NTE.

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The effect of spin exchange interaction on protein structural stability

Abstract: Partially charged chiral molecules act as spin filters, with preference for electron transport toward one type of spin ("up" or "down"), depending on their handedness. This effect is named the...

Cited by 3 publications

References 49 publications

Nuclear spin effects in biological processes

Nuclear spin effects in biological processes

Chiral Induced Spin Selectivity

Quantum Biology and the Potential Role of Entanglement and Tunneling in Non-Targeted Effects of Ionizing Radiation: A Review and Proposed Model

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