The effect of statins on the development of new-onset type 2 diabetes: a meta-analysis of randomized controlled trials

Use of statins and the incidence of type 2 diabetes mellitus

“…Analysis of studies conducted after the Woscops showed inconsistent relationship between statin use and diabetes. 21,22 However, more recent analyzes corroborated the findings of the JUPITER study.…”

Statins Cardiovascular Benefits Outweigh their Diabetogenicity: A Direct Comparison between Number Needed to Treat and Number Needed to Harm

“…First, the diagnostic criteria of NODM were different between studies, with some including an initiation of pharmacotherapy and some including personal or a physician report [12][13][14]. Second, patients carrying a higher number of risk factors for DM are more susceptible to statin-induced NODM than those carrying a smaller number of risk factors for DM [42][43][44].…”

“…Even in RCTs, the risk of NODM was reduced by 30% with pravastatin [9], was neutral with simvastatin [10], but was nonsignificantly increased by 15% with atorvastatin [11]. Against these backgrounds, several metaanalyses [12][13][14][15][16][17][18][19] have been conducted and have yielded possible evidence of a statin-DM association. However, such evidence -the increased likelihood of NODM in statin users than nonusers or in intensive rather than moderate dose users-does not indicate whether NODM is really harmful and consequently cancels any cardioprotective benefit of statin.…”

Antioxidant Effects of Statins in the Management of Cardiometabolic Disorders

“…Althoughstatinshavebeenproventobeeffective inreducingCVD,conflictingdataexistregardingthe effects of some statins on the risk of incident T2DM 91,141,142) .Interestingly,ameta-analysisofrandomized controlled trials suggested potential differences between individual statins, with pravastatin showingatrendtowardreducingmetabolicrisksand atorvastatin, rosuvastatin and simvastatin together being associated with a significantly increased risk of T2DM vs. a placebo 89) . More recent analyses have demonstrated an increased incidence of diabetes followingstatintreatment,regardlessofthestatintype 91,142) .…”

“…Statin therapy decreases cholesterol synthesis by inhibiting3-hydroxy-3-methylglutarylCoAreductase, whichsubsequentlyincreasestheactivityoftheLDL receptoranddecreasestheconcentrationofLDL-cholesterolintheplasma.Inmanylargetrials,treatment withstatinshasbeenshowntodecreasecardiovascular morbidity and mortality by reducing LDL [86][87][88][89][90] . In additiontotheirLDL-loweringactions,statinspossess antioxidant and anti-inflammatory properties that may contribute to their cardioprotective effects [91][92][93] .…”