The effect of sub-acute and sub-chronic exposure of rats to the glyphosate-based herbicide Roundup

Çağlar, Selim Süalp; Kolankaya, Dürdane

doi:10.1016/j.etap.2007.08.011

Cited by 63 publications

(27 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, there was a relatively high ALT activity in the G and the GC groups compared to the DW group. This elevation in the activity of ALT following subchronic glyphosate exposure in this study agreed with the result of previous studies (Caglar and Kolankaya 2008; El-Shenawy 2009), which reported increased level of ALT in rats which was said to be part of the diagnostic symptoms of liver diseases, and also supported the hypothesis which stated that the increased serum transaminases (ALT and AST) might reflect hepatotoxicity which leads to extensive liberation of enzymes in the blood (Daabees et al 1992). The reason for the apparently high serum ALT activity in the Z group is not known for certain, but it might be due to its pro-oxidant effect as reported by Abdallah and Samman (1993) since the rats were not under oxidative stress.…”

Section: Resultssupporting

confidence: 94%

See 1 more Smart Citation

Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc

et al. 2013

View full text Add to dashboard Cite

A subchronic toxicity study was carried out to assess hepatic and renal functions of rats during oral exposure to glyphosate with zinc for the period of 8 weeks. Forty-eight Wistar rats used for the study were randomized into six groups of eight Wistar rats each, and each group had equal number of male and female Wistar rats. The Wistar rats administered with distilled water at 2 ml/kg body weight served as the control group (DW); others were administered with zinc at 50 mg/kg body weight (Z) group, glyphosate at 375 mg/kg body weight (G) group, a combination of zinc and glyphosate at 50 and 375 mg/kg body weight, respectively (Z + G), group, glyphosate at 14.4 mg/kg body weight (GC) group, and a combination of zinc and glyphosate at 50 and 14.4 mg/kg body weight, respectively (Z + GC), group. At the end of the study, blood samples were collected from each rats; from which, sera samples were obtained and assayed for total protein, albumin, alanine and aspartate aminotransferases, alkaline phosphatase, Na+, K+, Cl−, , Ca2+, , urea and creatinine using autoanalyzer, and globulin was calculated. The albumin concentration was significantly high (p < 0.05) in GC group compared to DW group, and this change was ameliorated following supplementation with zinc. The total protein and globulin concentrations did not differ significantly between the groups (p > 0.05), and the relative changes were ameliorated by supplementation with zinc. The alkaline phosphatase activity was relatively low in GC group; however, supplementation with zinc in Z + GC group made it to be significantly high (p < 0.05) compared to GC group. The alanine and aspartate aminotransferases in G and GC groups were relatively high compared to DW group, which were ameliorated by supplementation with zinc. The relatively low Ca2+ concentration in G and GC groups compared to DW were ameliorated in Z + G group, and it was significantly high in Z + GC group at p < 0.01 compared to DW, p < 0.001 compared to G and GC groups and p < 0.05 compared to Z + G group. There were only slight changes in the electrolytes concentrations (Na+, K+, Cl−, and ), which were differentially ameliorated by zinc supplementation. The reasons for the various changes recorded were discussed. It was concluded that subchronic oral exposure to glyphosate caused both hepatic and renal functions toxicity in rats, which were ameliorated by zinc supplementation.

show abstract

Section: Resultssupporting

confidence: 94%

“…This finding is in agreement with those reported by Caglar and Kolankaya (2008) who studied the effect of 56 and 560 mg/kg/day Roundup® and glyphosate and reported increased level of urea by 2.1-fold and 1.9-fold compared to the control, respectively. The elevation of blood urea is a good indicator for kidney dysfunction.…”

Section: Resultssupporting

confidence: 93%

Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The rats exposed to the low dose of glyphosate in the GC group had no observable microscopic lesion. These observations are in tandem with the previous studies (Benedetti et al 2004; Caglar and Kolankaya 2008) where increased Kupffer cells were seen in hepatic sinusoids of glyphosate-treated rats exposed to higher doses, 487 and 560 mg/kg, respectively, unlike in those rats exposed to 4.87, 48.7 or 56 mg/kg. The infiltration of Kupffer cells were followed by large deposition of reticular fibers, mononuclear cell infiltration and congestion of the liver tissues Benedetti et al (2004) reported that these could have contributed to the impairment of regular function of the liver due to xenobiotics modification in detoxification processes.…”

Section: Discussionsupporting

confidence: 90%

Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate

et al. 2013

View full text Add to dashboard Cite

A subchronic toxicity study was carried out to determine the glyphosate-induced histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen of rats and the attendant ameliorative effect when pretreated with zinc at the dose rate of 50 mg/kg body weight. The rats were exposed to two doses of the glyphosate (375 and 14.4 mg/kg body weight) for the period of 8 weeks which was the duration of the study, and some groups were exposed to the glyphosate after pretreatment with zinc. The histopathological changes recorded during the study were only in the rats exposed to the glyphosate at the dose rate of 375 mg/kg body weight except the vacuolation encountered in the brains and haemosiderosis in the spleens of rats exposed to zinc alone. Degenerated mucosal epithelial cells which involved the muscularis mucosa and the glands in the stomachs of rats were seen microscopically. Hepatic cells degeneration especially at the portal areas of the livers of rats was observed. The histopathological examination of the kidneys showed glomerular degeneration, mononuclear cells infiltration into the interstices of the tubules and tubular necrosis. The conspicuous changes seen in the brains were neuronal degeneration. Pancreatic acinar cells were degenerated while the spleen of the rats showed depopulated splenic cells in both the red and the white pulps. It was concluded that zinc supplementation in rats prior to glyphosate exposure ameliorated the histopathological changes observed in the stomach, liver, kidney, brain, pancreas and spleen with no observable alteration in the histoarchitecture in the organs of the zinc-supplemented rats.

show abstract

“…Sonuçlar değer-lendirildiğinde GlBH'nin karaciğer metabolizması ve hasarında etkili olabileceği bildirilmektedir. 48 Sı-çanlara 5 hafta boyunca 10 mg/kg dozda uygulanan glifosatın karaciğer, böbrek ve plazmada antioksidan savunma sistemini stimüle ettiği görülmüştür. 49 Brezilya'da içme sularında glifosat için kabul edilebilir düzey olan 0,07 ppm, sıçanlara ekstrapole edilerek 0,09 mg/kg dozda uygulanmıştır.…”

Section: Karaci̇ğer Ve Böbrek üZeri̇ne Etki̇leri̇unclassified

Human Health Risks of the Use of Glyphosate and Glyphosate-Based Herbicides: Review

Sarıaltın¹,

Çoban²

2017

Turkiye Klinikleri J Pharm Sci

View full text Add to dashboard Cite

The effect of sub-acute and sub-chronic exposure of rats to the glyphosate-based herbicide Roundup

Cited by 63 publications

References 5 publications

Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc

Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc

Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate

Human Health Risks of the Use of Glyphosate and Glyphosate-Based Herbicides: Review

Contact Info

Product

Resources

About