The Effect of Submucosal Injection of Plasma Rich Platelets on the Rate of Orthodontically Induced Canine Retraction in Subject with Bimaxillary Protrusion

Abstract

Objective: The present study aimed to reveal the effects of submucosal injection of Plasma Rich Platelets (PRP) on the rate of canine retraction. 
 Methods: Eighteen females with bimaxillary protrusion were selected from patients seeking orthodontic treatment, College of the Dentistry/University of Sulaimani, whose maxillary and mandibular first premolars were decided to be extracted after proper diagnosis. It’s a split-mouth design; the upper left side was the control side while the upper right side served as the intervention side (submucosal injection of PRP); after aligning and leveling, the retraction phase was initiated on .017× .025 Stainless steel archwire with power chain from the canine bracket to temporary anchorage device inserted between the upper 2nd premolar and 1st molar at the same level for both sides. The elastomeric chains were changed every two weeks. Scanned intraoral images were obtained by intra- oral CEREC omnicam scanner before retraction and at the end of retraction to measure the amount of canine movement using inLab CAM 15.0 software 2015.
 Results: A highly significant acceleration of canine retraction on the intervention side compared with the control side at p <.0001 with a rate of 29.1% higher overall retraction phase (108 days). 
 Conclusions: Submucosal injection of PRP is a minimally-invasive and low-cost method that can be used for accelerating orthodontic tooth movement.

Effect of Platelet Based Preparation on Orthodontic Tooth Movement in Rabbits

“…7 , Gulec et al 8 Sufarnap et al 9 and Nakornnoi et al 10 in their prospective animal studies. The effect of PRP injection also agreed with Khalid 11 , and Ali 12 as they showed increased OTM rate in their human clinical trials after using PRP.…”

Platelet-rich plasma's (PRP) impacts on accelerated canine movement

“…According to Eric J.W. Liou's research, we chose P = 0.7[ 5 ] and the sample size was 31 participants.…”

“…[ 4 ] Several articles concluded the reliable effects of PRP from 2017 and minimal intervention in accelerated orthodontic tooth movement which can shorten the length of orthodontics treatment duration. [ 4 5 6 ]…”

Methods of measuring distal canine movement and rotation- A review

“…Ali and Chawshli,[ 40 ] using a CEREC Omnicam scanner and Laboratory CAM 15.0 software, evaluated the distance between the distal connecter of the canine and the mesial connecter of the second premolar on both sides before and after canine retraction [ Figure 3a ].…”