The effect of sugammadex on steroid hormones: A randomized clinical study

Gul, Gulay Gunduz; Özer, Ayşe Belin; Demirel, İsmail; Aksu, Ahmet; Erhan, Ömer Lütfi

doi:10.1016/j.jclinane.2016.03.039

Cited by 20 publications

(22 citation statements)

References 12 publications

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“…The fact that pregnancy continued to develop normally without abortus or stillbirth suggests that sugammadex can be used safely on day 12 of pregnancy. A different study, however, reported that administration of sugammadex had no effect on serum P4 levels [12] . Because endogenous steroids similar to P4, like rocuronium, do not contain the ammonium compounds found in steroidal neuromuscular blockers, sugammadex reportedly demonstrates low affinity for these steroids [30,31] .…”

Section: Discussionmentioning

confidence: 94%

“…If the neuromuscular junction does not adequately recover after anesthesia, post-operative pulmonary complications may develop, and mortality rates can rise [10] . Therefore, sugammadex, a neuromuscular blocker antagonist has been used in recent years to eliminate residual muscle relaxation [12] .…”

Section: Discussionmentioning

confidence: 99%

“…Serious complications can result due to the risk of residual curarization. Sugammadex is widely used to eliminate residual neuromuscular muscle relaxation [12] . Studies have reported that sugammadex interacts with and binds to externally administered medicinal products, thus reducing the medicines' effect [12,28] .…”

Section: Discussionmentioning

confidence: 99%

“…Sugammadex is widely used to eliminate residual neuromuscular muscle relaxation [12] . Studies have reported that sugammadex interacts with and binds to externally administered medicinal products, thus reducing the medicines' effect [12,28] . It is not recommended for use in women during pregnancy because there is no clinical data and minimal placental transfer is possible [29] .…”

Section: Discussionmentioning

confidence: 99%

“…Because endogenous steroids similar to P4, like rocuronium, do not contain the ammonium compounds found in steroidal neuromuscular blockers, sugammadex reportedly demonstrates low affinity for these steroids [30,31] . Furthermore, steroidal hormones contribute to this low affinity because they bind strongly to special transporter proteins [12,31] . In our study, on day 21 of pregnancy, there was a significant decline in serum P4 levels at 60 and 90 min in Group II compared to levels prior to sugammadex administration.…”

Section: Discussionmentioning

confidence: 99%

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Genel Anesteziye Altındaki Gebe Tavşanlarda Rocuronium ve Sugammadex’in Progesteron Düzeyine Etkisi

Türk¹,

Kaya²,

Dönmez³

et al. 2018

Kafkas Univ Vet Fak Derg

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The purpose of this study was to investigate the effect of rocuronium and sugammadex on progesterone (P4) levels in pregnant rabbits under general anesthesia. Twenty-one pregnant New Zealand rabbits were used in the study. After the rabbits were divided into three groups of three (Control, Group I and Group II), each animal was given 0.5 mg/kg midazolam and 6 mg/kg propofol and then put under general anesthesia with sevoflurane on the 21 st day of pregnancy. No procedure was performed on the control group apart from anesthesia. Rocuronium was administered to GI at the onset of anesthesia, and in GII, sugammadex was administered 60 min after general anesthesia + rocuronium. All of the rabbits were monitored during the anesthesia procedure. A sample of venous blood was taken and biochemically analyzed to test P4 levels. The administration of rocuronium was determined to have caused an increase in the serum progesterone level in all recorded min. Sugammadex was found to cause a quantitative decrease in the level of progesterone. In conclusion, it was found out that rocuronium and sugammadex administration did not have a negative effect on progesterone levels in pregnant rabbits receiving general anesthesia.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Genel Anesteziye Altındaki Gebe Tavşanlarda Rocuronium ve Sugammadex’in Progesteron Düzeyine Etkisi

Türk¹,

Kaya²,

Dönmez³

et al. 2018

Kafkas Univ Vet Fak Derg

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Potential interaction between exogenous anabolic steroids and sugammadex: failed reversal of rocuronium in a patient taking testosterone and trestolone acetate

Farkas,

Aeberhard,

Schiffer

et al. 2023

Anaesthesia Reports

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Effect of sugammadex administration on neural tube development in 48‐h chick embryos

Büyükerkmen,

Atay,

Firat

et al. 2023

Microscopy Res & Technique

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Sugammadex is a new generation drug that has led to significant changes in the practice of anesthesia. However, its effects on fetal development are not yet fully known. The aim of this study is to investigate the teratogenic effects of sugammadex on neural tube and embryonic development in early chick embryos. In this study, 50 0‐day fertile specific non‐pathogenic (SPF) eggs were used. Fifty eggs were divided into 5 different groups, each consisting of 10 pieces. While no substance was given to the control group at the 28th hour of the study, 4 different doses of sugammadex were administered to the experimental groups, respectively 2, 4, 8, 16 mg/kg. Cranio‐caudal lengths of embryos, somite numbers, average number of argyrophilic nucleolar regulatory regions (AgNOR) per nucleus, total AgNOR area/total nuclear area (TAA/NA) ratios, Caspase‐3 H‐Score results, and presence of neural tube defect were compared among the groups. While the mean cranio‐caudal lengths, somite counts, TAA/NA ratios and AgNOR counts of the embryos were found to be statistically significantly lower than the control group, Caspase‐3 H‐Score mean results were found to be significantly higher (p < .05). In addition, it was observed that there was an increase in neural tube patency and developmental delay. As a result, sugammadex crossing the placenta was revealed to increase the release of proapopitotic molecules and disrupt the developmental stages of embryos. Thus, it was determined that sugammadex in increased developmental delay and incidence of neural tube defects in early chick embryos with increased dose dependent. Despite these results, the effects of sugammadex on fetal development in in vivo and in vitro environments should be studied with further studies.Research Highlights Sugammadex is a new generation drug that has led to significant changes in the practice of anesthesia. However, its effects on fetal development are not yet fully known. It has been observed that different doses of sugammadex increase the risk of neural tube defect development on chick embryos and slow the embryo development in a dose‐dependent manner.

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The effect of sugammadex on steroid hormones: A randomized clinical study

Cited by 20 publications

References 12 publications

Genel Anesteziye Altındaki Gebe Tavşanlarda Rocuronium ve Sugammadex’in Progesteron Düzeyine Etkisi

Genel Anesteziye Altındaki Gebe Tavşanlarda Rocuronium ve Sugammadex’in Progesteron Düzeyine Etkisi

Potential interaction between exogenous anabolic steroids and sugammadex: failed reversal of rocuronium in a patient taking testosterone and trestolone acetate

Effect of sugammadex administration on neural tube development in 48‐h chick embryos

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