The effect of sulfite and chronic restraint stress on brain lipid peroxidation and anti-oxidant enzyme activities

Derın, Narin; Yargiçoğlu, Pi̇raye; Aslan, Mutay; Elmas, Oğuz; Ağar, Ayşel; Aicigüzel, Yakup

doi:10.1191/0748233706th264oa

Cited by 28 publications

(19 citation statements)

References 52 publications

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“…Here, no differences between the groups were found on TBARS determination. These results agree with some reports from the literature [31,35], although several studies have shown increased TBARS in brain structures of chronically stressed animals [21,36,37]. These differences may be related to the use of different models of chronic stress (different stressors and different periods of exposure to stress).…”

Section: Discussionsupporting

confidence: 92%

Interactions Between Chronic Stress and Chronic Consumption of Caffeine on the Enzymatic Antioxidant System

et al. 2009

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We studied the effect of chronic caffeine on parameters related to oxidative stress in different brain regions of stressed and non-stressed rats. Wistar rats were divided into three groups: control (receiving water), caffeine 0.3 g/L and caffeine 1.0 g/L (in the drinking water). These groups were subdivided into non-stressed and stressed (repeated restraint stress during 40 days). Lipid peroxide levels and the total radical-trapping potential were assessed, as well as antioxidant enzyme activities superoxide dismutase, gluthatione peroxidase, and catalase in hippocampus, striatum and cerebral cortex. Results showed interactions between stress and caffeine, especially in the cerebral cortex, since caffeine increased the activity of some antioxidant enzymes, but not in stressed animals. We concluded that chronic administration of caffeine led, in some cases, to increased activity of antioxidant enzymes. However, these effects were not observed in the stressed animals.

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Section: Discussionsupporting

confidence: 92%

Interactions Between Chronic Stress and Chronic Consumption of Caffeine on the Enzymatic Antioxidant System

et al. 2009

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“…Furthermore, both our assays for intra-oocyte ROS and glutathione and CCC supplementation to IVM medium demonstrated that restraint stress increased oxidative stress in oocytes. It has been reported that stresses including restraint stress cause the disruption of homeostasis and an imbalanced antioxidant status in blood and several organs (Sahin et al 2004, Derin et al 2006, Sahin & Gü mü şlü 2007. However, stress-induced oxidative stress has not been observed in ovaries, although our previous study has indicated that restraint stress causes oxidative stress in oocytes (Zhou et al 2012).…”

Section: Discussionmentioning

confidence: 99%

“…In somatic cells, physical and psychological stressors cause oxidative stress by upsetting the balance between prooxidant and antioxidant status (Ejchel-Cohen et al 2006, Zafir & Banu 2009). Furthermore, studies using rat models have demonstrated that restraint stress induces oxidative stress in different organs (Zaidi et al 2003, Derin et al 2006, Sahin et al 2006, Akpinar et al 2008. However, although our recent study has provided preliminary evidence that maternal restraint stress increases oxidative stress in the oocyte (Zhou et al 2012), reports on whether restraint stress causes oxidative stress in the ovary are limited.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant supplementation overcomes the deleterious effects of maternal restraint stress-induced oxidative stress on mouse oocytes

Lian¹,

Gao²,

Jiao³

et al. 2013

Reproduction

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In this study, using a mouse model, we tested the hypothesis that restraint stress would impair the developmental potential of oocytes by causing oxidative stress and that antioxidant supplementation could overcome the adverse effect of stress-induced oxidative stress. Female mice were subjected to restraint stress for 24 h starting 24 h after equine chorionic gonadotropin injection. At the end of stress exposure, mice were either killed to recover oocytes for in vitro maturation (IVM) or injected with human chorionic gonadotropin and caged with male mice to observe in vivo development. The effect of antioxidants was tested in vitro by adding them to IVM medium or in vivo by maternal injection immediately before restraint stress exposure. Assays carried out to determine total oxidant and antioxidant status, oxidative stress index, and reactive oxygen species (ROS) and glutathione levels indicated that restraint stress increased oxidative stress in mouse serum, ovaries, and oocytes. Whereas the percentage of blastocysts and number of cells per blastocyst decreased significantly in oocytes from restraint-stressed mice, addition of antioxidants to IVM medium significantly improved their blastocyst development. Supplementation of cystine and cysteamine to IVM medium reduced ROS levels and aneuploidy while increasing glutathione synthesis and improving pre-and postimplantation development of oocytes from restraint-stressed mice. Furthermore, injection of the antioxidant epigallocatechin gallate into restraint-stressed mice significantly improved the blastocyst formation and postimplantation development of their oocytes. In conclusion, restraint stress at the oocyte prematuration stage impaired the developmental potential of oocytes by increasing oxidative stress and addition of antioxidants to IVM medium or maternal antioxidant injection overcame the detrimental effect of stress-induced oxidative stress. The data reported herein are helpful when making attempts to increase the chances of a successful outcome in human IVF, because restraint was applied at a stage similar to the FSH stimulation period in a human IVF program.

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“…Five sulfite salts including sodium metabisulfite (Na 2 S 2 O 5 ), potassium metabisulfite (K 2 S 2 O 5 ), sodium sulfite (Na 2 SO 3 ), sodium bisulfite (NaHSO 3 ), potassium sulfite (K 2 SO 3 ) are commonly used as antioxidants in food preparations (Elmas et al, 2005). In addition to this, studies have postulated that under certain conditions, sodium metabisulfite may act through cell disruption and compromise membrane permeability and lipid peroxidation (Derin et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Oxidative damage on the testes of adult rats by sodium metabisulfite (MBS)

Adebayo¹,

Adenuga²

2012

Int. J. Bio. Chem. Sci

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The effect of sodium metabisulfite (MBS, Na 2 S 2 O 5 ) on the level of malondialdehyde (MDA), testes weight and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) as well as the level of glutathione (GSH) were investigated in the testes of Wistar albino rats. The study was performed to elucidate the effect of MBS (520 mg/kg/day) ingestion on lipid peroxidation and the antioxidant enzymes activities. The results showed that MDA level as well as the activity of SOD was significantly increased in MBS-treated rats whereas the weight of the testes as well as the level of GSH was not significantly affected. However, there was significant reduction in the activity of CAT in the MBS-treated rats compared to the control. The presented data showed that ingestion of MBS has adverse effect on testes as it induced oxidative damage, reflected by increase lipid peroxidation and impairment in the activities of antioxidant enzymes.

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The effect of sulfite and chronic restraint stress on brain lipid peroxidation and anti-oxidant enzyme activities

Cited by 28 publications

References 52 publications

Interactions Between Chronic Stress and Chronic Consumption of Caffeine on the Enzymatic Antioxidant System

Interactions Between Chronic Stress and Chronic Consumption of Caffeine on the Enzymatic Antioxidant System

Antioxidant supplementation overcomes the deleterious effects of maternal restraint stress-induced oxidative stress on mouse oocytes

Oxidative damage on the testes of adult rats by sodium metabisulfite (MBS)

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