The effect of surgical trauma on the bacterial translocation from the gut

Salman, Fatih; Buyruk, Murat; Gürler, Nezahat; Çelik, Alaaddin

doi:10.1016/0022-3468(92)90368-h

Cited by 35 publications

(18 citation statements)

References 9 publications

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“…BT is caused and enhanced by hemorrhagic shock, burn injury, intestinal obstruction, total parenteral nutrition, antibiotic therapy, malnutrition and trauma [10, 11, 12, 13, 14, 15]. Physiopathological events causing BT have not yet been fully elucidated, but three major mechanisms have been proposed to explain this process: (1) bacterial overgrowth; (2) impairment in host immune defenses, and (3) increased permeability of the intestinal mucosal barrier [5, 6, 16].…”

Section: Discussionmentioning

confidence: 99%

Does Rigid Bronchoscopy Induce Bacterial Translocation?

Özkurt

Herek²,

Atalay³

et al. 2005

Respiration

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Background: Although some reports suggest that bronchoscopy induces bacterial translocation (BT), the mechanisms of BT remain unclear. Objective: We aimed to assess whether bronchoscopy or hypoxemia during bronchoscopy is responsible for BT. Methods: We evaluated 24 rats divided into three subgroups: the control group (group 1, n = 8); the rigid bronchoscopy group (group 2, n = 8), and the group receiving bronchoscopy + mechanical ventilation (group 3, n = 8). Oxygen saturation (SaO₂) was measured during the bronchoscopic procedure. Blood and tissue cultures from mesenteric lymph nodes (MLNs), liver, spleen and cecal contents were obtained 24 h following bronchoscopy. Results: In group 2, SaO₂ was significantly lower than in groups 1 and 3 (p < 0.01). In group 2, BT significantly increased (6/8, 75%; p < 0.01 vs. group 1, and p < 0.05 vs. group 3). The main site of translocation was MLNs (6/8, 75%) in group 2, while BT was detected in only 1 rat in group 3 (1/8, 12.5%). Conclusion: Hypoxemia during rigid bronchoscopy resulted in intestinal mucosal damage in a rat model. Hypoxemia may have been the trigger for BT from the intestine following bronchoscopy.

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Section: Discussionmentioning

confidence: 99%

Does Rigid Bronchoscopy Induce Bacterial Translocation?

Özkurt

Herek²,

Atalay³

et al. 2005

Respiration

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“…The gut mucosa in these critically ill patients may not serve as a barrier against the passage of gut bacteria, whereby BT occurs. [1][2][3][4][5][6][7][8]22 Experimental studies have shown a decrease in splanchnic blood flow immediately after thermal injury. This results in decreased intestinal blood flow, leading to tissue hypoxia, which plays a key role in the deterioration of intestinal barrier function.…”

Section: Discussionmentioning

confidence: 99%

“…Under the pathophysiological conditions of critically ill patients, it stands to reason that the gut mucosal barrier and immunological functions may be impaired after the dissemination of pathogenic substances into the systemic circulation, which can trigger the pathophysiological changes causing sepsis and multiple organ failure. [1][2][3][4][5][6][7][8] Various treatment modalities have been proposed to prevent the occurrence of BT resulting from gut barrier damage. It is well known that immunonutrition supports both the immunological and metabolic functions of the gut, and reduces gut mucosal damage and bacterial translocation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Probiotic Supplementation on Bacterial Translocation in Thermal Injury

et al. 2005

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“…Translocation of gut bacteria across the intestinal mucosa is believed to occur easily when host immunity is impaired by stress such as a burn injury or surgical trauma in a rat model [15,18]. We examined the incidence of bacteria in the mesenteric lymph node and the spleen as bacterial translocation.…”

Section: Discussionmentioning

confidence: 99%

“…In a model of major surgical trauma, bacteria normally confined to the gut cross the intestinal mucosal barrier and appear in the mesenteric lymph nodes and other organs. This process, termed bacterial translocation, is believed to occur in relation to surgical stress [15,18].…”

mentioning

confidence: 99%