The effect of systemic antibiotics on clinical and patient‐reported outcome measures of oral implant therapy with simultaneous guided bone regeneration

Abstract

Objectives:The aim of the present superiority study was to determine the effect of systemic antibiotics primarily on patient-reported outcome measures (PROMs) and post-surgical complications in patients undergoing oral implant therapy with simultaneous guided bone regeneration (GBR). Materials and Methods:A total of 236 medically and periodontally healthy patients received oral implants with simultaneous GBR at seven centres. Pre-operative antibiotics of 2 g amoxicillin were prescribed to the test group 1 hr prior to surgery and 500 mg thrice daily on days 1-3 after surgery. The control group was given a placebo.Group allocation was performed randomly. Primary outcome variables were PROMs recorded as visual analogue scale scores assessed on days 1-7 and 14 on pain, swelling, haematoma and bleeding. Post-operative complications as secondary outcome variables were examined at 1, 2, 4 and 12 weeks from surgery. Chi-square tests and repeated measures of analysis of variance (ANOVA) were performed for statistical evaluation. Results:No statistically significant differences (p > .05) between the two groups were detected for the evaluated PROMs. The same was noted with respect to postsurgical complications. Four implants were lost-three in the test group and one in the control group. Conclusion:In this trial, systemic antibiotics did not provide additional benefits to PROMs, nor the prevention of post-surgical complications in medically and periodontally healthy patients undergoing oral implant therapy with simultaneous GBR.However, further studies with larger sample sizes are still required to support the clinical outcomes of this study. | 443PAYER Et Al.

Wedge-Shaped Implants for Minimally Invasive Treatment of Narrow Ridges: A Multicenter Prospective Cohort Study

“…In a study by Pistilli et al, 2014, 50% of patients still reported moderate pain 10 days after autogenous bone block augmentation [ 51 ]. A recent multicenter study on implants inserted with simultaneous guided bone regeneration showed VAS pain scores higher than those reported in the present study during the entire week after surgery [ 52 ].…”

Combinatorial Effect of Cold Atmosphere Plasma (CAP) and the Anticancer Drug Cisplatin on Oral Squamous Cell Cancer Therapy

“…In our opinion, 1 μM cisplatin plus 3 min of CAP treatment or 3 μM cisplatin plus 1 min of CAP treatment are the preferred combination options rather than other treatment regimens, because the viability of cancer cells was sufficiently inhibited, while the viability of HGF-1 cells remained higher than 60%. Furthermore, local treatment of disease in the periodontal region is required to improve therapeutic efficacy because it is hard to reach the periodontal region with the systemic delivery of drugs [ 46 ]. Thus, the local treatment modality should be developed to maximize drug efficacy against the periodontal and gingival region [ 47 , 48 ].…”

Antibiotics or No Antibiotics, That Is the Question: An Update on Efficient and Effective Use of Antibiotics in Dental Practice

“…AP must be considered as a possible choice related to a specific case and a specific patient in order to modulate bacterial load and potential inflammation and promote an atraumatic surgical technique [ 11 ]. On the other hand, treatment of suppurative oro-facial infections must be classified as septic surgeries, although in this case the use of antibiotics as AT can be reduced and modulated according to specific clinical situations [ 12 ].…”

“…Additionally, smoking can cause a high rate of postsurgical local infections [ 70 ]. By practicing a correct preoperative disinfection of the operating field, with elimination of bacterial biofilms and tartar, and maintaining a low bacterial load in the postoperative healing phase, it is possible to reduce the onset of an inflammatory response and incidence of potential local infections, avoiding AT [ 11 , 23 ].…”

“…Bacterial contamination can determine colonization of bone substitutes, bone grafts and barrier membranes used in regenerative techniques or surface implants [ 11 ]. Due to the lack of blood vessels, these biomaterials provide a protected substrate for bacterial colonies, hindering their elimination and resulting in persistent inflammation [ 73 ].…”