The Effect of Taxifolin on Acrylamide-induced Oxidative and Proinflammatory Brain Injury in Rats: A Biochemical and Histopathological Study

Ersoy, Alevtina; Yaşar, Hasan; Tanoğlu, Ceyda; Yazıcı, Gülce Naz; Çoban, Taha Abdulkadir; Arslan, Yusuf; Süleyman, Halis

doi:10.5530/ijper.55.3s.183

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…It has been reported that ACR (30 mg/kg bw) exposure for 2 weeks resulted in hepatotoxicity accompanied by elevated levels of IL-1β and IL-6 in rats . In a 30 day study, gavage ACR (20 mg/kg bw) was found to induce significant elevation of serum IL-1β and TNF-α and chronic inflammation in rats . It was also found that ACR decreases the antioxidant enzymatic activity such as SOD and GSH-Px leading to a decrease in GSH levels and MDA accumulation, which ultimately causes oxidative stress .…”

Section: Discussionmentioning

confidence: 96%

“…33 In a 30 day study, gavage ACR (20 mg/kg bw) was found to induce significant elevation of serum IL-1β and TNF-α and chronic inflammation in rats. 34 It was also found that ACR decreases the antioxidant enzymatic activity such as SOD and GSH-Px leading to a decrease in GSH levels and MDA accumulation, which ultimately causes oxidative stress. 9 Another study found that ACR exposure reduces the enzymatic activity of antioxidant enzymes and elevates the levels of oxidative markers, inducing oxidative stress in BRL-3A cells, suggesting that it causes cell damage.…”

Section: Discussionmentioning

confidence: 99%

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Acrylamide-Aggravated Liver Injury by Activating Endoplasmic Reticulum Stress in Female Mice with Diabetes

Guo,

Zhao,

Yao

et al. 2024

Chem. Res. Toxicol.

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Acrylamide (ACR) is a common industrial contaminant with endocrine-disrupting toxicity. Numerous studies have indicated that females and diabetics are more sensitive to environmental contaminants. However, it remains unknown whether female diabetics are susceptible to ACR-induced toxicity and its potential mechanisms. Thus, the female ACR-exposure diabetic Balb/c mice model was established to address these issues. Results showed that ACR could induce liver injury in normal mice and cause more serious inflammatory cell infiltration, hepatocyte volume increase, and fusion in diabetic mice liver. Meanwhile, ACR could lead to exacerbation of diabetic symptoms in diabetic mice by disturbing the glucose and lipid metabolism in the liver, which mainly manifests as the accumulation of liver glycogen and liver lipids, the reduction of the activity/content of glycolytic and metabolizing enzyme as well as pentose phosphatase, upregulation of the gene expression in fatty acid transporter and gluconeogenesis, and downregulation of the gene expression in fatty acid synthesis and metabolism. Moreover, ACR exposure could induce oxidative stress, inflammation, and endoplasmic reticulum stress in the liver by a decrease in hepatic antioxidant enzyme activity and antioxidant content, an increase in inflammatory factor levels, and a change in the related protein expression of endoplasmic reticulum stress (ERS) and apoptosis-related pathways in diabetic mice. Statistical analysis results revealed that ACR-induced liver injury was highly correlated with inflammation and oxidative stress, and ERS and diabetic mice had a higher risk of liver injury than normal mice. Overall results suggested that female diabetic mice easily suffer from ACR-induced toxicity, and the reason was that ACR could induce further damage to the liver by worsening the condition of inflammation, oxidative stress, and ERS in the liver.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Acrylamide-Aggravated Liver Injury by Activating Endoplasmic Reticulum Stress in Female Mice with Diabetes

Guo,

Zhao,

Yao

et al. 2024

Chem. Res. Toxicol.

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“…This was observed in a rat model that was administered acrylamide orally with concentrations ranging from 5 to 20 mg kg −1 day −1 for 60 days [46]. Acrylamide exposure increased Tumor Necrosis Factor-Alpha (TNF-α) levels, causing inflammation in the brain tissues by the release of various cytokines due to oxidative stress induced by acrylamide [47]. Acrylamide exposure can cause polymorphisms in the gene responsible for the functioning of the cytochrome in the lungs, thereby affecting the metabolism of acrylamide in the human body, which was analyzed using the dried blood spot samples of lung cancer patients [48].…”

Section: Genotoxicity and Carcinogenicitymentioning

confidence: 96%

Dietary Acrylamide: A Detailed Review on Formation, Detection, Mitigation, and Its Health Impacts

Govindaraju,

Sana,

Chakraborty

et al. 2024

Foods

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In today’s fast-paced world, people increasingly rely on a variety of processed foods due to their busy lifestyles. The enhanced flavors, vibrant colors, and ease of accessibility at reasonable prices have made ready-to-eat foods the easiest and simplest choice to satiate hunger, especially those that undergo thermal processing. However, these foods often contain an unsaturated amide called ‘Acrylamide’, known by its chemical name 2-propenamide, which is a contaminant formed when a carbohydrate- or protein-rich food product is thermally processed at more than 120 °C through methods like frying, baking, or roasting. Consuming foods with elevated levels of acrylamide can induce harmful toxicity such as neurotoxicity, hepatoxicity, cardiovascular toxicity, reproductive toxicity, and prenatal and postnatal toxicity. This review delves into the major pathways and factors influencing acrylamide formation in food, discusses its adverse effects on human health, and explores recent techniques for the detection and mitigation of acrylamide in food. This review could be of interest to a wide audience in the food industry that manufactures processed foods. A multi-faceted strategy is necessary to identify and resolve the factors responsible for the browning of food, ensure safety standards, and preserve essential food quality traits.

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Assessment of the preventive activity of Pinus brutia Ten. (Pinaceae) against in vivo acute lung injury model

Süntar,

Demirel,

Taban

et al. 2023

Phytochemistry Letters

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The Effect of Taxifolin on Acrylamide-induced Oxidative and Proinflammatory Brain Injury in Rats: A Biochemical and Histopathological Study

Cited by 5 publications

References 36 publications

Acrylamide-Aggravated Liver Injury by Activating Endoplasmic Reticulum Stress in Female Mice with Diabetes

Acrylamide-Aggravated Liver Injury by Activating Endoplasmic Reticulum Stress in Female Mice with Diabetes

Dietary Acrylamide: A Detailed Review on Formation, Detection, Mitigation, and Its Health Impacts

Assessment of the preventive activity of Pinus brutia Ten. (Pinaceae) against in vivo acute lung injury model

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