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Background. Cisplatin, used in cancer treatment, has toxic and apoptotic effects on the peripheral nervous system. Rutin, also known as vitamin P, has antioxidant and antiapoptotic activity. Objectives. The purpose of this study was to investigate the biochemical and histopathologic efficacy of rutin on neurotoxic and apoptotic effects caused by cisplatin in the peripheral nervous system. Material and methods. Twenty-four albino Wistar male rats were divided into the following 4 groups: control group (CG), only cisplatin-injected group (CIS), cisplatin and rutin 50 mg/kg (RG-50)-injected group, and cisplatin and rutin 100 mg/kg (RG-100)-injected group. Analyses were performed on sciatic nerve tissue of experimental animals. Analyses of malondialdehyde (MDA), total glutathione (tGSH), glutathione reductase (GSHRd), glutathione-s-transferase (GST), and superoxide dismutase (SOD) were performed. Caspase-3 expression in nerve tissue was also investigated. The analyzed groups were compared with CG. Results. Biochemical investigation shows that there is a statistically significant difference between CG and only CIS and RG-50. Control group and RG-100 were found to be similar. Cisplatin-induced changes were observed in histopathological analysis of the nerve tissue. The RG-100 and CG were found to be similar. The caspase-3 expression in the neural tissue was compared between groups. Control group and CIS were found to be different. Control group and RG-100 were found to be similar. Conclusions. Antioxidant and antiapoptotic effectiveness of rutin was detected against the toxic effects caused by cisplatin in the peripheral nerve tissue.

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Introduction: Myofascial pain syndrome is a painful local or regional disease caused by myofascial trigger points. Trigger point injection (TPI) is a frequently used method for the treatment of myofascial pain. Major complications associated with TPI have rarely been reported in the literature.Case Report: A 24-year-old woman, without medical history of any disease, was diagnosed with myofascial syndrome based on the presence of long-standing neck and right arm pain, and TPI with lidocaine was applied to the right trapezius region. During the procedure, blurred vision and loss of strength in the left arm occurred. Magnetic resonance and computed tomography imaging of the brain revealed findings that were consistent with an ischemic stroke in the right capsular interna and right occipital region. Conclusion:The reported patient is the first in the literature who suffered from ischemic stroke after TPI. The use of ultrasound for injections into the neck muscles could avoid serious complications.

Aim: Anti-tumor necrosis factor-alpha (TNF-α) drug treatments are widely used in many inflammatory diseases. Neurological complications have rarely been reported in these treatments. Our aim in this study was to investigate the neurological findings that occurred in our patients receiving this treatment. Methods: A case-control study conducted in (institutional information was blinded) between September 2018-September 2019. The study included 35 patients receiving tumor necrosis factor-alpha blocker drug, and 37 healthy control subjects with similar demographic characteristics. The disease activity scores of the patient group and physical function scores of the patient and control groups were questioned. All patients underwent a detailed physical and neurological examination. Afterward, peripheral nerves were evaluated neurophysiologically. According to distribution Mann-Whitney U test or independent samples t-test was used when comparing groups. The relationship between Short Form-36 and age or body mass index was determined by using Spearman's rank correlation coefficient. Results: The results obtained in sensory and motor nerve conduction examinations were compared between groups. Patients using anti-tumor necrosis factor-alpha had peripheral sensory neuropathy. Examination of peripheral motor nerves was within normal limits. Conclusions: Anti-tumor necrosis factor-alpha drugs have good effects in inflammatory diseases. These patients should be carefully monitored for neurological findings.