The Effect of Tea Consumption on Oxidative Stress in Smokers and Nonsmokers

Klaunig, James E.; Xu, Yong; Chen, Han; Kamendulis, Lisa M.; Chen, J.; Heiser, Carla; Gordon, Michael; Mohler, Emile R.

doi:10.3181/00379727-220-44375

Cited by 36 publications

(16 citation statements)

References 13 publications

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“…Others also demonstrated SOD and catalase were significantly upregulated both in vivo rat model and in smokers (1,(39)(40)(41). In this model, Chinese green tea (Lung Chen) probably arrests multiple harmful mechanisms of lung injury through protection of cells and tissues from oxidative damage by scavenging oxygen-free radicals generated from cigarette smoke exposure, in agreement with previous reports (42,43). Consequently, we observed a protection of lung morphology after 56-day CS exposure.…”

Section: Discussionsupporting

confidence: 90%

Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats

Chan

Yeung

et al. 2009

Respiratory Medicine

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Section: Discussionsupporting

confidence: 90%

Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats

Chan

Yeung

et al. 2009

Respiratory Medicine

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“…Overall, a decrease in 8‐oxodG was observed whenever the intervention was 3 months or longer,41, 42 but not after 1 month or less 42, 43. The exception is one study in which a decrease was observed after only 7 days 44. No change in urinary 8‐oxodG was seen after 4 months of intervention with black tea 41.…”

Section: Discussionmentioning

confidence: 93%

Determination of 8‐oxo‐2′‐deoxyguanosine and creatinine in murine and human urine by liquid chromatography/tandem mass spectrometry: application to chemoprevention studies

Teichert

Verschoyle

Greaves

et al. 2008

Rapid Comm Mass Spectrometry

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Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) represents a non-invasive biomarker for oxidative stress and may be useful for monitoring chemotherapeutic and chemopreventive interventions associated with cancer-related alterations in oxidative stress. We describe the development and validation of two separate liquid chromatography/tandem mass spectrometry (LC/MS/MS) selected reaction monitoring (SRM) methods for the determination of 8-oxodG and creatinine in both murine and human urine using stable isotope labelled internal standards. Levels of 8-oxodG were normalised to creatinine. The LC/MS/MS methods were applied to two chemoprevention studies utilising tea polyphenols in humans and TRAMP (TRansgenic Adenocarcinoma of the Mouse Prostate) mice. Patients with benign prostatic hyperplasia received 1 g/day of green tea polyphenols (GTP), 1 g/day of black tea theaflavins (BTT) or no treatment for 4 weeks. TRAMP mice received GTP (0.05% in drinking water) for 4 or 25 weeks. Prostate pathology in TRAMP mice was not affected by GTP. Levels of 8-oxodG were not altered by tea polyphenols in either mice or humans. In TRAMP mice, urinary 8-oxodG levels were elevated with increasing age (p < 0.0001) but not changed by the presence of prostate tumours. In conclusion, the LC/MS/MS SRM methods described here are ideally suited for the accurate determination of 8-oxodG and creatinine in urine samples from both clinical and pre-clinical studies.

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“…Clinical studies have found an inverse association between tea consumption and oxidative stress ( 25 – 27 , 50 ) . For example, by observing nineteen people in a 5-d experimental study, Stote et al ( 50 ) found that green tea consumption could lower plasma levels of F 2 -IsoP.…”

Section: Discussionmentioning

confidence: 99%

Tea consumption and oxidative stress: a cross-sectional analysis of 889 premenopausal women from the Sister Study

et al. 2019

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In experimental and clinical studies, green or black tea consumption has been shown to reduce oxidative stress. However, these studies involved high levels of tea consumption and may not reflect patterns in the general population. Here, we examined the association between black or green tea consumption and oxidative stress in a cross-sectional study of 889 premenopausal US women aged 35–54 years. Tea consumption was measured using the Block-98 FFQ. Urinary 8-iso-PGF2α (F2-IsoP) and 2,3-dinor-5,6-dihydro-15-F2t-isoprostane (15-F2t-IsoP-M) were used as biomarkers of oxidative stress. These compounds were measured by MS and normalised to creatinine. Linear regression was used to calculate the geometric mean differences (GMD) and 95% CI for log-transformed urinary F2-IsoP or 15-F2t-IsoP-M in relation to black or green tea consumption. We further examined whether adjusting for caffeine impacted associations between tea and oxidative stress. Geometric means of urinary F2-IsoP and 15-F2t-IsoP-M were 1·44 (95% CI 1·39, 1·49) and 0·71 (95% CI 0·69, 0·73) ng/mg creatinine, respectively. Overall, green tea consumption was not associated with urinary F2-IsoP or 15-F2t-IsoP-M. High-level black tea consumption (≥5 cups/week compared with 0) was associated with higher 15-F2t-IsoP-M concentrations (adjusted GMD=0·10, 95 % CI 0·02–0.19) but not F2-IsoP. Adjusting for caffeine nullified the association between black tea and 15-F2t-IsoP-M. Our findings do not support the hypothesis that dietary tea consumption is inversely associated with oxidative stress.

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The Effect of Tea Consumption on Oxidative Stress in Smokers and Nonsmokers

Cited by 36 publications

References 13 publications

Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats

Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats

Determination of 8‐oxo‐2′‐deoxyguanosine and creatinine in murine and human urine by liquid chromatography/tandem mass spectrometry: application to chemoprevention studies

Tea consumption and oxidative stress: a cross-sectional analysis of 889 premenopausal women from the Sister Study

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