The effect of tea on iron and aluminium metabolism in the rat

Fairweather‐Tait, Susan J.; Piper, Zoe; Fatemi, Seyed Jamilaldin; Moore, Geoffrey R.

doi:10.1079/bjn19910066

Cited by 44 publications

(16 citation statements)

References 12 publications

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“…Reports of CT complexes with other cations are scarce and usually related to tea consumption. Tea tannins have been reported to inhibit Al absorption in humans and rats (Fairweather-Tait et al, 1991), but was found to have no effect in other studies (Greger and Lyle, 1988).…”

Section: The Interactions Between Minerals and Condensed Tanninsmentioning

confidence: 98%

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

et al. 2017

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-Tannins represent one of the most abundant polyphenolic compounds in plants. Tannins exist as a multitude of chemically unique entities in nature. The most commonly occurring tannins are typically divided into two major classes based on chemical structure: hydrolysable (HT) or condensed tannins (CT). Hydrolysable tannins are esters of gallic or ellagic acid linked to a polyol core, typically glucose. Condensed tannins or proanthocyanidins consist of flavan-3-ol subunits linked together to form oligomers and polymers. Both HT and CT are defined as astringent, medium-to-high-molecular weight polyphenolic compounds that characteristically bind and precipitate soluble proteins. The objective of this paper was to present recent advances in CT-ruminant interactions, the limitations associated with understanding and using CT in ruminant animal production, and future needs for research to further advance our knowledge of the role of CT in optimization of ruminant animal production. Condensed tannins pose some anti-nutritional problems to ruminants due to their astringent property that reduces feed intake and, consequently, animal performance. Ruminants can, however, tolerate CT by slowly adapting the ruminal microbes to the toxic effects of CT and by releasing CT-binding salivary proteins. The protein-binding ability of CT has some benefits to the ruminant due to complexes formed with essential amino acids, preventing their degradation in the rumen, but releasing them in the lower gut for absorption by the animal. Recent data have suggested increased N retention when CT is given to growing animals. There are potential benefits of using CT and HT for anthelmintic purposes due to their ability to inhibit egg hatching and larval motility of gastrointestinal nematode parasites, especially in small ruminants. Condensed tannins also bind to minerals (Al, Ca, Co, Cu, Fe, Mg, Mn, P, and Zn). Although studies with ruminants have been contradictory, it has been reported that because the CT-metal ion complex is stable over a wide pH range, CT may reduce the bioavailability of minerals. Methane mitigation by feeding CT might be the most impactful benefit for ruminant production. Many empirical equations have been developed to predict ruminal methane emissions, but very few have included CT. Future research should focus on the improvement of methodology to assess CT biological activity, interaction with other plant-specialized metabolites, and associated physiological and nutritional impacts on ruminants.

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Section: The Interactions Between Minerals and Condensed Tanninsmentioning

confidence: 98%

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

et al. 2017

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“…Although some work has suggested that the absorption of A1 after tea drinking is increased (Koch et al 1988), this measured total A1 in 24 h urine and did not take into account the diuretic effect of tea, nor has it been supported in studies with rats (Fairweather-Tait et al 1991). Tea inhibits the absorption of non-haem-Fe from the diet (Disler et al 1975;Fairweather-Tait et al 1991) and it is possible that a similar inhibitory effect on absorption of A1 from other dietary sources is seen when food is taken with tea.…”

Section: Other Ligandsmentioning

confidence: 99%

The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption

Powell

Thompson

1993

Proc. Nutr. Soc.

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A large number of experimental studies have been carried out on the intestinal absorption and/or uptake of Al, and on the factors that affect this. However, apart from the well-known problems of contamination and the difficulty of analysis of Al, many of these studies have been flawed, particularly when experimental solutions have been used, since often it has not been realized that the A1 has precipitated at physiological pH. Other problems have included inappropriate use of buffers (such as containing phosphate) and extrapolation of results from unphysiologically high levels to dietary levels.Here we shall assess the chemistry, uptake and absorption of A1 from the gastrointestinal tract, and in particular consider the importance of dietary, rather than pharmacological, levels to which the general population is exposed.

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“…Some scholars believe that iron deficiency in the body is significantly associated with iron content in tissues. The iron concentration in the liver and spleen is usually higher than other tissues (Fischer et al, 2002), so it is often used to evaluate the iron status of the body (Fairweather-Tait, Piper, Fatemi, & Moore, 1991;Fischer et al, 2002;Park, Bacon, Brittenham, & Tavill, 1987;Whittaker et al, 1997). There was no significant difference in iron content between the iron supplement groups in the kidneys and liver of the mice, probably due to the faster catabolism of iron in the liver and kidneys.…”

Section: Weight Change and Tissue Iron Contentmentioning

confidence: 99%

Influences of different Fe sources on Fe bioavailability and homeostasis in SD rats

Lin

Shu

et al. 2019

Animal Science Journal

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The purpose of this study was to determine whether the enteric coating process affects growth performance, Fe bioavailability, and gene expression levels that maintain iron balance in the body. The test was divided into the control group, ferrous sulfate group, ferrous fumarate group, ferrous glycine chelate(1:1) (Fe‐Gly(1:1)) group, ferrous glycine chelate(2:1) (Fe‐Gly(2:1)) group, enteric‐coated Fe‐Gly(1:1) group, and enteric‐coated Fe‐Gly(2:1) group. The results showed that the growth performance of the rats in each iron supplement group was no significant difference among them. The results of serum biochemical indicators showed that the antioxidant capacity of the rats in the iron supplement group after enteric coating increased. The iron supplementation effect of Fe‐Gly(1:1) and Fe‐Gly(2:1) was better than that of ferrous sulfate, and the effect of Fe‐Gly(1:1) after enteric coating was enhanced. The expression levels of IRP1 and IRP2 in the genes of enteric‐coated Fe‐Gly(1:1) and enteric‐coated Fe‐Gly(2:1) were significantly higher than those of ferrous sulfate. The expression levels of IRP1 and IRP2 in the protein of enteric‐coated Fe‐Gly(1:1) group were significantly higher than those in the Fe‐Gly(1:1) group. The above results show that Fe‐Gly can improve the bioavailability and antioxidant capacity of iron and reduce the iron output of feces after enteric coating.

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The effect of tea on iron and aluminium metabolism in the rat

Cited by 44 publications

References 12 publications

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption

Influences of different Fe sources on Fe bioavailability and homeostasis in SD rats

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