The Effect of the Administration of Estrogen on the Mechanism of Ascorbic Acid Excretion in the Dog

Abstract

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The effects of stilboestrol on the renal activity of conscious dogs

“…The present results reinforce this view, since alterations in electrolyte excretion sometimes preceded changes in clearances; moreover, in diabetes insipidus, clearances and electrolyte excretion did not alter in the same sense. It follows from the work of Thorn & Engel (1938), of Selkurt et al (1943) and from the present work that the effect of stilboestrol on renal function is not essentially dependent on a rise in G.F.R. or R.P.F., or the presence of either adrenals or gonads, but that the response is altered by interference with the supraoptico-hypophysial system.…”

“…Measurements of renal clearances showed that stilboestrol caused some rise in G.F.R. as was found by Selkurt et al (1943), but an even greater rise in R.P.F. The changed clearances, like the change in water and Na excretion, lasted for a number of days.…”

“…There is no information about the tissue water in dogs, but the prolonged effects of stilboestrol treatment suggest that in dogs (and man) recovery is slower than in rats. Haematocrit readings were not affected by stilboestrol (Table 2); this finding appears to differ from that of Selkurt et al (1943), but their results are probably related to the fact that they used large and repeated doses of oestradiol; in any case, they concluded that the changes in renal activity preceded the onset of anaemia. In that sense the present results are in agreement with theirs.…”

“…Over the same period retention of K was minimal in some animals and more evident in others. Selkurt et al (1943) found that a castrated male dog, like a normal dog, retained water and Na on treatment with stilboestrol. Similarly, in the present work an ovariectomized female responded to stilboestrol in the normal manner.…”

“…The dogs which had undergone pituitary or hypothalamic operations showed some increase in the clearance values after treatment with stilboestrol which may perhaps be attributed to the drug, but the effects were more erratic than normal, and seemed to fade more rapidly. From their results, Selkurt et al (1943) concluded that the alteration in clearance in normal dogs was not an integral part of the change in excretory activity. The present results reinforce this view, since alterations in electrolyte excretion sometimes preceded changes in clearances; moreover, in diabetes insipidus, clearances and electrolyte excretion did not alter in the same sense.…”