2005
DOI: 10.1016/j.ijpharm.2004.11.024
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The effect of the amount of binder liquid on the granulation mechanisms and structure of microcrystalline cellulose granules prepared by high shear granulation

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Cited by 44 publications
(13 citation statements)
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“…[33][34][35][36] An increase in the amount of water added enhanced the granule coalescence because the higher water saturation allowed the deformation of the granules, which resulted in an increase in the amount of water available at the their surface. This resulted in the growth of the granules growth and their densication during the HSWG process.…”
Section: Quantitative Data Analysis By Plsmentioning
confidence: 99%
“…[33][34][35][36] An increase in the amount of water added enhanced the granule coalescence because the higher water saturation allowed the deformation of the granules, which resulted in an increase in the amount of water available at the their surface. This resulted in the growth of the granules growth and their densication during the HSWG process.…”
Section: Quantitative Data Analysis By Plsmentioning
confidence: 99%
“…We used both ethanol and water during wet granulation, whereas Ohno et al used water only. Millili and Schwartz reported that granules produced using water alone had a higher mechanical strength than granules produced using a mixture of ethanol and water (70 : 30), 25) suggesting that the binding force of xylitol may have been decreased by the influence of ethanol in the current study. Thus, the amount of binder may be little effect on dissolution rate of tablet using PCS.…”
Section: Effects Of Amount Of Binder and Pcs On Tablet Propertiesmentioning
confidence: 55%
“…Analysis of the cross-sectional images was then conducted using CTAn (Bruker microCT n.v., Kontich, Belgium) software. The procedure for image processing using NRecon ® and CTAn software was earlier described by Crean et al 17) In the present study, the intragranular region was analyzed as the "region of interest (ROI)," and the boundary region was excluded from the analysis. Thus, the definition of "porosity of granules" in this study means the porosity of intra-granules.…”
Section: Experimental Materialsmentioning
confidence: 99%
“…For example, Farber et al 16) studied porosity, pore size distribution, and geometric structure of pores in granules produced using different conditions and materials. Crean et al 17) elucidated the internal physical and chemical microstructure of pharmaceutical granules in conjunction with spectroscopic methods. Bouwman et al 18) investigated the effect of the amount of binder liquid on the granulation mechanisms and structure of granules prepared by high shear granulation.…”
Section: Introductionmentioning
confidence: 99%