The effect of the DLTIDDSYWYRI motif of the human laminin α2 chain on implant osseointegration

Kang, Hyun; Kim, O. Bok; Min, Seung‐Ki; Jung, Sung Youn; Jang, Da Hyun; Kwon, Taesoo; Min, Byung‐Moo; Yeo, In‐Sung

doi:10.1016/j.biomaterials.2013.02.023

Cited by 26 publications

(36 citation statements)

References 44 publications

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“…DLTIDDSYWYRI is an active motif from the large globular 1 domain of human laminin-2 a2 chain that promotes osteoblast differentiation [157,158]. DLTIDDSYWYRI acts through syndecan-1 on the cell membrane resulting in phosphorylation of downstream protein kinase C (PKC) delta leading to cell adhesion and enhanced osteointegration of implants coated with the peptide in vivo [158,159]. GFOGER is a peptide which resembles sequences on the collagen I α1(I) chain.…”

Section: Implant Surface Enhancements For Enhanced Osteointegrationmentioning

confidence: 99%

Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings

Zhang

Myers

Wallace

et al. 2014

IJMS

336

165

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Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic loosening and infection are the two most significant causes of prosthetic implant failure. The ideal implant should be able to promote osteointegration, deter bacterial adhesion and minimize prosthetic infection. Recent developments in material science and cell biology have seen the development of new orthopaedic implant coatings to address these issues. Coatings consisting of bioceramics, extracellular matrix proteins, biological peptides or growth factors impart bioactivity and biocompatibility to the metallic surface of conventional orthopaedic prosthesis that promote bone ingrowth and differentiation of stem cells into osteoblasts leading to enhanced osteointegration of the implant. Furthermore, coatings such as silver, nitric oxide, antibiotics, antiseptics and antimicrobial peptides with anti-microbial properties have also been developed, which show promise in reducing bacterial adhesion and prosthetic infections. This review summarizes some of the recent developments in coatings for orthopaedic implants.

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Section: Implant Surface Enhancements For Enhanced Osteointegrationmentioning

confidence: 99%

Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings

Zhang

Myers

Wallace

et al. 2014

IJMS

336

165

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“…One type of laminin‐derived peptide is the DLTIDDSYWYRI motif (also known as Ln2‐P3), which originates from the human laminin α2 chain. Bone healing is markedly accelerated when commercially pure titanium (Ti) dental implants are treated with Ln2‐P3 (Kang et al, ). The mechanism by which this acceleration occurs involves syndecan‐1, which is a transmembrane proteoglycan receptor expressed on osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

A laminin‐211‐derived bioactive peptide promotes the osseointegration of a sandblasted, large‐grit, acid‐etched titanium implant

Choi

Kim

et al. 2020

J Biomedical Materials Res

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Early implant loading is very important for reducing the duration of missing teeth in human patients. The laminin‐derived peptide, DLTIDDSYWYRI motif (Ln2‐P3), accelerates bone healing. Therefore, to investigate the hypothesis that Ln2‐P3 increases the bone response to sandblasted, large‐grit, acid‐etched (SLA) titanium implants, the effect of the Ln2‐P3 peptide on the osseointegration of SLA titanium implants was evaluated in vitro and in vivo. Human osteoblast‐like cells were cultured on untreated, scrambled peptide (SP)‐treated, and Ln2‐P3‐treated SLA titanium discs, and the cellular responses of these cells were evaluated. The Ln2‐P3 treatment augmented osteoblast attachment and spreading, alkaline phosphatase activity, and the expression of osteogenic marker genes. Furthermore, the untreated and Ln2‐P3‐treated SLA titanium implants were inserted into the tibiae of rabbits for 9 and 11 days. Compared with the untreated implants, the Ln2‐P3‐treated implants showed a significantly higher bone‐to‐implant contact ratio at Day 9 after implantation and an increased bone area. The Ln2‐P3 treatment of the SLA titanium implant surface augmented osteoblastic activity and accelerated peri‐implant bone formation at the bone–implant interface. Overall, these results indicated that compared with the SLA titanium surface alone, the Ln2‐P3 peptide‐treated SLA titanium surface enhances initial osseointegration, thereby facilitating earlier implant loading.

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“…Recombinant human bone morphogenetic protein 2 (rhBMP-2) coated on an oxidized Ti surface enhanced the bone affinity and healing capacity of the surface, compared with the oxidized Ti surface only [67]. Furthermore, several short peptides, derived from cell adhesion proteins, have been effective in bone cell attachment and are non-antigenic to implant surfaces [70,71]. Both in vitro and in vivo experiments show promising results in terms of biologic responses surrounding protein or peptide-coated implants [71,72].…”

mentioning

confidence: 99%

“…Furthermore, several short peptides, derived from cell adhesion proteins, have been effective in bone cell attachment and are non-antigenic to implant surfaces [70,71]. Both in vitro and in vivo experiments show promising results in terms of biologic responses surrounding protein or peptide-coated implants [71,72]. A laminin-derived peptide showed the increased expression of the osteogenic markers at the gene level, the enhanced alkaline phosphatase activity at the protein level, the improved attachment and spreading of osteoblast-like cells, and the accelerated bone response in the rabbit tibia model [71].…”

mentioning

confidence: 99%

“…Both in vitro and in vivo experiments show promising results in terms of biologic responses surrounding protein or peptide-coated implants [71,72]. A laminin-derived peptide showed the increased expression of the osteogenic markers at the gene level, the enhanced alkaline phosphatase activity at the protein level, the improved attachment and spreading of osteoblast-like cells, and the accelerated bone response in the rabbit tibia model [71]. Stronger osseointegration to the rhBMP-2 coated implant was also confirmed in another previous study with a sheep iliac model [72].…”

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confidence: 99%

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Reality of Dental Implant Surface Modification: A Short Literature Review

Yeo¹

2014

TOBEJ

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Screw-shaped endosseous implants that have a turned surface of commercially pure titanium have a disadvantage of requiring a long time for osseointegration while those implants have shown long-term clinical success in single and multiple restorations. Titanium implant surfaces have been modified in various ways to improve biocompatibility and accelerate osseointegration, which results in a shorter edentulous period for a patient. This article reviewed some important modified titanium surfaces, exploring the in vitro, in vivo and clinical results that numerous comparison studies reported. Several methods are widely used to modify the topography or chemistry of titanium surface, including blasting, acid etching, anodic oxidation, fluoride treatment, and calcium phosphate coating. Such modified surfaces demonstrate faster and stronger osseointegration than the turned commercially pure titanium surface. However, there have been many studies finding no significant differences in in vivo bone responses among the modified surfaces. Considering those in vivo results, physical properties like roughening by sandblasting and acid etching may be major contributors to favorable bone response in biological environments over chemical properties obtained from various modifications including fluoride treatment and calcium phosphate application. Recently, hydrophilic properties added to the roughened surfaces or some osteogenic peptides coated on the surfaces have shown higher biocompatibility and have induced faster osseointegration, compared to the existing modified surfaces. However, the long-term clinical studies about those innovative surfaces are still lacking.

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The effect of the DLTIDDSYWYRI motif of the human laminin α2 chain on implant osseointegration

Cited by 26 publications

References 44 publications

Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings

Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings

A laminin‐211‐derived bioactive peptide promotes the osseointegration of a sandblasted, large‐grit, acid‐etched titanium implant

Reality of Dental Implant Surface Modification: A Short Literature Review

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