The effect of the essential oil of<i>Eugenia caryophyllata</i>in animal models of depression and locomotor activity

Mehta, Ashish; Halder, Sumita; Khanna, N; Op, Tandon; Sharma, Krishna K.

doi:10.1179/1476830512y.0000000051

Cited by 18 publications

(9 citation statements)

References 40 publications

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“…The main constituents of its EO include thymol (40.94 %), carvacrol (22.23 %), p-cymene (7.73 %), linalool (7.92 %), caryophyllene (3.95), and γ-terpinene[34]. Majlessi et al[35] mentioned the beneficial effects of EO from the leaves of ZM in ICV Aβ(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35))-induced AD model in rats. Seven days after induction of disease, EO was administered in a dose of 50, 100, and 200 µg/mL (i. p.) 30 min prior to MWM task.…”

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confidence: 99%

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Benny

Thomas

2018

Planta Med

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Alzheimerʼs disease is a multifarious neurodegenerative disease that causes cognitive impairment and gradual memory loss. Several hypotheses have been put forward to postulate its pathophysiology. Currently, few drugs are available for the management of Alzheimerʼs disease and the treatment provides only symptomatic relief. Our aim is to review the relevant in vitro, in vivo, and clinical studies focused toward the potential uses of essential oils in the treatment of Alzheimerʼs disease. Scientific databases such as PubMed, ScienceDirect, Scopus, and Google Scholar from April 1998 to June 2018 were explored to collect data. We have conducted wide search on various essential oils used in different models of Alzheimerʼs disease. Out of 55 essential oils identified for Alzheimerʼs intervention, 28 have been included in the present review. A short description of in vivo studies of 13 essential oils together with clinical trial data of Salvia officinalis, Salvia lavandulifolia, Melissa officinalis, Lavandula angustifolia, and Rosmarinus officinalis have been highlighted. In vitro studies of remaining essential oils that possess antioxidant and anticholinesterase potential are also mentioned. Our literary survey revealed encouraging results regarding the various essential oils being studied in preclinical and clinical studies of Alzheimerʼs disease with significant effects in modulating the pathology through anti-amyloid, antioxidants, anticholinesterase, and memory-enhancement activity.

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confidence: 99%

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Benny

Thomas

2018

Planta Med

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“…The rota-rod test is a safe and efficient test to assess an animal's motor coordination and balance. It has been employed to directly measure the influence of essential oils and their components on the central nervous system [ 50 , 51 ]. Another advantage of the rota-rod test is that it allows distinguishing analgesic or anti-inflammatory effects from possible sedative effects since nonspecific muscle relaxation effects may reduce motor coordination and mask the mice's response to nociception [ 30 ].…”

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confidence: 99%

Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation

Silva

Oliveira

Fernandes

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background Breu is an aromatic oleoresin which has been used by Amazonian traditional communities as a remedy for headaches and migraines by burning and inhaling the smoke produced during its combustion. This study evaluated the antinociceptive and sedative activities of formulations containing breu essential oils administered by inhalation. Methods Five different formulations (A–E) containing breu essential oils were evaluated for their sedative and antinociceptive activities in mice. They were delivered for 20 minutes using an inhalation chamber coupled with a nebulizer and the air inside was collected by static headspace and analyzed by GC-FID. Results All nebulized formulations had similar chemical compositions and major compounds as the original essential oils. None of them resulted in significant increase in response time during the hot plate test. In the formalin test, Formulation E showed a significant inhibition of licking responses in the early (46.8%) and late (60.2%) phases. Formulation B was effective (36.9%) in the first phase and Formulation D (37.9%) in the second. None of the formulations presented sedative effects. Conclusion Breu essential oils, when inhaled, may present antinociceptive and anti-inflammatory properties without sedation. Additionally, nebulization proved to be an efficient method for administration of formulations containing these essential oils.

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“…The bio compound has dianthus (Eugenia caryophyllata) essential oil as its component which is known as a powerful analgesic and anti-inflammatory, working also as an antiseptic against bacteria and fungi (Mehta et al, 2013). This oil has eugenol as its main component and it is responsible for its medical properties (Singh et al, 2012) and the melaleuca essential oil has antimicrobial and anti-inflammatory properties (Edmondson et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Healing bio compound for the treatment of fissures in the diabetic foot

Silva

Lopes

et al. 2019

BJHR

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The effect of the essential oil ofEugenia caryophyllatain animal models of depression and locomotor activity

Abstract: Thus, it can be concluded that pretreatment with clove oil decreases depression and enhances locomotor activity similar to that exhibited by psychostimulants.

Cited by 18 publications

References 40 publications

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation

Healing bio compound for the treatment of fissures in the diabetic foot

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