The Effect of the Modified Endoscopic Lothrop Procedure on the Mucociliary Clearance of the Frontal Sinus in an Animal Model

Abstract

The MEL procedure has no adverse effects on the mucociliary clearance of the frontal sinus at 3 months postoperatively. Irrigation of the frontal sinus in the immediate postoperative period showed a trend toward improved postoperative mucociliary function at 3 months.

Endoscopic frontal sinusotomy—Preventing recurrence or a route to revision?

“…Messerklinger developed the endoscopic technique with the aim of relieving diseased sinuses while preserving mucosa and at the same time being minimally invasive 2. Although the technique has previously been championed,3 other endoscopic techniques have gained recent vogue, namely the modified Lothrop4, 5 (frontal sinus drill out) and balloon sinuplasty 6–8. Combined and open approaches to the frontal sinus are also available options, such as trephination9, 10 and osteoplastic flaps with or without obliteration 11–13.…”

Radiofrequency volumetric tissue reduction of the inferior turbinate in a sheep model

“…Coronal computed tomography imaging of sheep sinonasal anatomy has demonstrated features similar to humans, especially with regard to the turbinates 13. Additionally, sheep nasal mucosa and sinonasal physiology have been shown to be analogous to humans 14, 15. Due to the limitations of obtaining tissue from humans, the sheep model thus provides a viable option for the study of the histopathologic effects of endonasal procedures.…”

“…The relative scarcity of histopathologic data reflects the practical and ethical concerns of obtaining turbinate tissue from patients following a minimally invasive endonasal turbinate reduction procedure. The sheep model has been investigated for the study of endonasal procedures and is particularly useful for assessing histopathology and wound healing of the sinonasal mucosa 13–16. This model accommodates the use of standard endoscopic sinus surgery equipment, allowing for accurate simulation of clinical procedures.…”

Effects of a Novel Chitosan Gel on Mucosal Wound Healing Following Endoscopic Sinus Surgery in a Sheep Model of Chronic Rhinosinusitis

“…The aim of this study was to determine the effect on nasal mucosal wound healing and adhesion formation of a CD gel, SprayGel, and rTF, using a well established validated wound‐healing model of ESS in sheep with chronic rhinosinusitis 32–38 …”