The effect of the new 2010 World Health Organization criteria for semen analyses on male infertility

Murray, Katie S.; James, Andrew; McGeady, James B.; Reed, Michael L.; Kuang, Wan; Nangia, Ajay K.

doi:10.1016/j.fertnstert.2012.07.1130

Cited by 92 publications

(65 citation statements)

References 15 publications

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“…The adoption of the new WHO reference values will likely lead to more men being classified as "fertile," which is of particular importance for gynecologists who rely on semen analysis alone as a surrogate measure for male fertility. In a recent study up to 15% of men with at least one parameter below the 1999 WHO reference values were reclassified as ''normal'' by having all parameters at or above the 2010 WHO thresholds (8). We have also contemplated our own data involving 982 men seeking evaluation for infertility that had abnormal semen analysis results based on the 1990 WHO criteria.…”

Section: Impact Of the 2010 Who Criteria For Semen Analysis In The Mamentioning

confidence: 99%

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Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination

2014

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Section: Impact Of the 2010 Who Criteria For Semen Analysis In The Mamentioning

confidence: 99%

“…Much debate has taken place thereafter, and a series of reports has questioned the validity of the newly released reference values (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination

2014

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“…We prospectively followed 184 couples undergoing stimulated-IUI cycles at our center during the study period. In order to be eligible for IUI treatment, semen parameters must have included at least 5 million sperm/mL and at least 25 % motility of grade A+B according to the 1999 WHO criteria for semen analysis, before the stimulation protocol was carried out [1]. Grade A is defined as sperm with progressive motility; grade B implies a non-linear motility.…”

Section: Methodsmentioning

confidence: 99%

Rescue in vitro fertilization using a GnRH antagonist in hyper-responders from gonadotropin intrauterine insemination (IUI) cycles

Balayla

Granger

St-Michel³

et al. 2013

J Assist Reprod Genet

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Objective To evaluate the outcomes in the conversion of high-response gonadotropin intrauterine insemination (IUI) cycles to "rescue" in vitro fertilization (IVF) using a Gonadotropin-Releasing Hormone (GnRH) antagonist, with regards to implantation rates, pregnancy rates, cost, and ovarian hyperstimulation syndrome (OHSS) as compared to matched, hyper-responder, IVF controls. Methods This prospective cohort study was conducted between January 2007 and December 2009 at our institution. In order to decrease high-order multiple pregnancy, minimize the incidence of OHSS, and avoid cycle cancellation, highresponse stimulated-IUI patients opted to convert to "rescue" IVF using the GnRH antagonist cetrorelix acetate. We then compared their clinical outcomes with matched patients from high-response IVF cycles of the standard long mid-luteal GnRH agonist protocol (14 or more collected oocytes). Only cases of conventional IVF without intra-cytoplasmic sperm injection (ICSI) were included in the control group.Results Out of 184 patients undergoing stimulated-IUI cycles with gonadotropins, 87 patients developed a hyperresponse, and 20 opted to convert to "rescue" IVF. These patients were compared with 157 matched, hyper responder IVF controls from our registry. The implantation rate was 25.6 % in the "rescue" IVF group and 20.7 % in the control IVF group (p<0.0047). The ongoing clinical pregnancy rate per embryo transfer was 45.0 % and 33.6 % in the "rescue" IVF and the control IVF groups, respectively (p<0.0001). The mean duration of stimulation was comparable between cohorts (10.0 vs.10.4 days, p=0.6324). The mean dose of gonadotropin used per cycle was higher in the control group, 2664 international units (IU) of follicle stimulation hormone (FSH) compared to 1450 IU of FSH in the "rescue" IVF group (p<0.0001). The incidence of severe OHSS is also higher in the control group, 5.1 % versus no cases in the "rescue" IVF group (p<0.0001). Conclusion Our study demonstrates that conversion of high-response gonadotropin-IUI cycles to "rescue" IVF using a GnRH antagonist is a cost-effective strategy that produces better results than regular IVF with relatively minimal morbidity, and shorter duration to achieve pregnancy. Implantation and ongoing clinical pregnancy rates tend to be higher than those from hyper-responder regular IVF patients. Capsule Conversion of high-response gonadotropin-IUI cycles to "rescue" IVF using a GnRH antagonist is a cost-effective strategy that produces better results than regular IVF.

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“…Нормативные показатели эякулята, предложенные в последнем издании Руководства Всемирной органи-зации здравоохранения (ВОЗ) по оценке и анализу эякулята (5-е издание (2010)) [2], вызвали полемику среди специалистов в области андрологии, спермато-логии и репродукции человека. Многие врачи-уроло-ги считают, что в связи с недостаточной строгостью предложенных критериев нарушения репродуктивной системы мужчин будут недооценены [3][4][5]. В послед-нем издании Руководства ВОЗ [2] использованы дан-ные из спермограмм мужчин, беременность у партнерш которых наступала в течение 12 мес половой жизни без предохранения.…”

Section: Introductionunclassified

Types of Pathozoospermia in Men With Infertility in Marriage Аnd/or Disorders of Reproductive System

Андреева¹,

Khayat²,

Сорокина³

et al. 2017

Androl. genit. hir.

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The effect of the new 2010 World Health Organization criteria for semen analyses on male infertility

Cited by 92 publications

References 15 publications

Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination

Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination

Rescue in vitro fertilization using a GnRH antagonist in hyper-responders from gonadotropin intrauterine insemination (IUI) cycles

Types of Pathozoospermia in Men With Infertility in Marriage Аnd/or Disorders of Reproductive System

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