The Effect of the Pituitary Adrenocorticotropic Hormone and of Corticosterone Acetate on Insulin Hypoglycemia and Liver Glycogen in Adrenalectomized Mice

Grattan, Jerome F.; Jensen, H.; Ingle, Dwight J.

doi:10.1152/ajplegacy.1941.134.1.8

Cited by 13 publications

(3 citation statements)

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“…Ingle (73) reported that 17-hydroxy ll-dehydrocorticosterone exerts a marked glycosuric effect also in the normal intact rat. More recent experiments on mice lend further support to the view that the anterior pituitary exerts its antagonistic effect to insulin by mediation of the adrenal cortex (74).…”

Section: Endocrine Factorsmentioning

confidence: 76%

Carbohydrate Metabolism

Somogyi¹

1942

Annu. Rev. Biochem.

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Section: Endocrine Factorsmentioning

confidence: 76%

Carbohydrate Metabolism

Somogyi¹

1942

Annu. Rev. Biochem.

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“…In adrenalectomized animals the corticosterones cause: (a) an increased rate of storage of liver glycogen (4,5,6,48), even in fasting animals; (b) an increase in urine nitrogen (48); (c) a decrease in carbohydrate oxidation (63); (d) a decrease in respiratory quotient (34,63); (e) a decrease in glycogenolysis (11,56); (f) an increase in the rate of conversion of keto acids to liver glycogen (45, 46); (g) an increase in blood sugar (5,63); (h) an increase in the resistance to insulin (20,21); and (i) an increase in the workcapacity of voluntary muscle (34).…”

Section: Fig 5 Response Inmentioning

confidence: 99%

Treatment of Adrenal Insufficiency

Williams

Whittenberger

Bissell

et al. 1945

The Journal of Clinical Endocrinology & Metabolism

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“…Various studies have shown that this hypoglycaemic effect of insulin may be inhibited by the presence of adrenocortical steroids (Grattan, Jenson & Ingle, 1941;DeBodo & Sinkoff, 1953). The anti-insulin action of adrenocortical hormones is considered to result from a mobilization of glycogen reserves, increased gluconeogenesis and inhibition of peripheral glucose utilization (DeBodo & Altszuler, 1958;Cahill, 1971).…”

mentioning

confidence: 99%

Metabolic effects of cortisol, ACTH, adrenalin and insulin in the marsupial sugar glider, Petaurus breviceps

Bradley

Stoddart²

1990

Journal of Endocrinology

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The effects of cortisol, ACTH, adrenalin and insulin on indices of carbohydrate, fat and protein metabolism were investigated in the conscious marsupial sugar glider Petaurus breviceps. Short-term i.v. infusion of cortisol at dose rates of 0.02, 0.2 and 1.0 mg/kg per h caused the plasma glucose concentration to rise sharply from the normal range of 3.3-4.4 to 8.1-8.7 mmol/l at the end of the infusion period without significant alteration in plasma free fatty acid (FFA), amino acid or urea concentrations. Infusions of ACTH at dose rates of 0.02, 0.06 and 0.45 IU/kg per h caused a similar rise in plasma glucose concentration; however, this was now accompanied by an elevation in plasma FFA concentration, but again without significant changes in either plasma amino acid or urea concentrations. Infusion of adrenalin at 10 micrograms/kg per h caused an increase in the plasma concentrations of both glucose and FFA. Intravenous injections of 0.15 IU insulin/kg caused a rapid and marked decrease in the plasma glucose concentration within 30 min and an increase in the plasma free cortisol concentration. Associated with this change was a marked rise in the plasma concentration of both FFA and free cortisol. The rise in free cortisol was, however, significantly reduced by infusion of glucose. Pretreatment with five daily i.m. injections of 1 mg cortisol acetate/kg, which produced an increase in plasma free cortisol concentration to near the maximum of the physiological range, caused a marked reduction in insulin sensitivity. Cortisol pretreatment caused an increase in the plasma FFA and amino acid concentrations. Petaurus breviceps is highly sensitive to the metabolic effects of glucocorticoids and is similar in this respect to the brush-tailed possum Trichosurus vulpecula. The interactive effects between insulin and glucocorticoids on carbohydrate, fat and protein metabolism in Petaurus breviceps are similar to those shown by Trichosurus vulpecula and some eutherian mammals but contrast with the pattern described for two macropodid marsupials, the red kangaroo Macropus rufus and the quokka Setonix brachyurus.

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The Effect of the Pituitary Adrenocorticotropic Hormone and of Corticosterone Acetate on Insulin Hypoglycemia and Liver Glycogen in Adrenalectomized Mice

Cited by 13 publications

References 0 publications

Carbohydrate Metabolism

Carbohydrate Metabolism

Treatment of Adrenal Insufficiency

Metabolic effects of cortisol, ACTH, adrenalin and insulin in the marsupial sugar glider, Petaurus breviceps

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