The effect of the selective activation of different peripheral nerve fiber groups on the somatosensory evoked potentials in the cat

Alpsan, D.

doi:10.1016/0013-4694(81)90203-0

Cited by 25 publications

(2 citation statements)

References 22 publications

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“…Moreover, the earliness of neurophysiological assessment prevents the possible interference of deep sedative medications like pentobarbital, which seems to suppress ML and long-latency SSEP in patients with severe head injuries [ 51 ]. However, experimental studies on recruitment of A delta fibers, as related to the strength of electrical stimulus applied on the peripheral nerve, show that pentobarbital does not suppress ML-SSEP [ 28 , 52 ]. Our previous experience showed that, in anesthetized patients, propofol and midazolam did not blunt the cortical reactivity of electrical stimulation of A delta nerve fibers on the median nerves [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, past studies showed that 40–70 ms potentials are localized in the para-Sylvian cortex near the lateral sulcus by the firing of the secondary somatosensory area (SII) and insula [ 27 ], that they can be activated by A delta nerve fibers [ 28 , 29 ], and that they are involved in the cortical representation of pain [ 30 ]. Several years later we had the opportunity to replicate the causal effect of A delta conduction fiber on ML-SSEP generation; indeed, we suppressed 40–70 ms potentials triggered by painful stimulus at 50 mA by blocking the median nerve sulcus with local anesthesia [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Pain-related Somato Sensory Evoked Potentials: a potential new tool to improve the prognostic prediction of coma after cardiac arrest

et al. 2015

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IntroductionEarly prediction of a good outcome in comatose patients after cardiac arrest still remains an unsolved problem. The main aim of the present study was to examine the accuracy of middle-latency SSEP triggered by a painful electrical stimulation on median nerves to predict a favorable outcome.MethodsNo- and low-flow times, pupillary reflex, Glasgow motor score and biochemical data were evaluated at ICU admission. The following were considered within 72 h of cardiac arrest: highest creatinine value, hyperthermia occurrence, EEG, SSEP at low- (10 mA) and high-intensity (50 mA) stimulation, and blood pressure reactivity to 50 mA. Intensive care treatments were also considered. Data were compared to survival, consciousness recovery and 6-month CPC (Cerebral Performance Category).ResultsPupillary reflex and EEG were statistically significant in predicting survival; the absence of blood pressure reactivity seems to predict brain death within 7 days of cardiac arrest. Middle- and short-latency SSEP were statistically significant in predicting consciousness recovery, and middle-latency SSEP was statistically significant in predicting 6-month CPC outcome. The prognostic capability of 50 mA middle-latency-SSEP was demonstrated to occur earlier than that of EEG reactivity.ConclusionsNeurophysiological evaluation constitutes the key to early information about the neurological prognostication of postanoxic coma. In particular, the presence of 50 mA middle-latency SSEP seems to be an early and reliable predictor of good neurological outcome, and its absence constitutes a marker of poor prognosis. Moreover, the absence 50 mA blood pressure reactivity seems to identify patients evolving towards the brain death.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pain-related Somato Sensory Evoked Potentials: a potential new tool to improve the prognostic prediction of coma after cardiac arrest

et al. 2015

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Short- and Long-Latency Median Somatosensory Evoked Potentials

Yamada¹,

Kimura²,

Wilkinson³

et al. 1983

Arch Neurol

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Somatosensory evoked potentials induced by stimulating a variable number of nerve fibers in rat

et al. 1993

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Somatosensory evoked potentials (SEPs) were recorded from rat spinal cord (sSEPs) and cerebral cortex (cSEPs). Stimulus sites included either one or both sural nerve branches having different fiber populations (group A), or distal to a lesion of controlled size of the sural nerve made 1 week earlier (group B). In the two groups of animals, amplitudes of SEPs correlated with the quantity of large myelinated nerve fibers. Peak latencies of sSEPs in group A related to the ratio of sizes of transmitting fibers. sSEPs and cSEPs in both groups A and B could be recorded in a reproducible fashion by stimulating sural nerve branches or lesioned nerve trunks containing only 100 or less nerve fibers greater than 4 microns in size. Thus, presence of sSEPs or cSEPs after stimulation distal to a lesion site does not insure that many nerve fibers have continuity with the central nervous system (CNS).

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The effect of the selective activation of different peripheral nerve fiber groups on the somatosensory evoked potentials in the cat

Cited by 25 publications

References 22 publications

Pain-related Somato Sensory Evoked Potentials: a potential new tool to improve the prognostic prediction of coma after cardiac arrest

Pain-related Somato Sensory Evoked Potentials: a potential new tool to improve the prognostic prediction of coma after cardiac arrest

Short- and Long-Latency Median Somatosensory Evoked Potentials

Somatosensory evoked potentials induced by stimulating a variable number of nerve fibers in rat

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