Objective
Aerobic capacity is the most powerful predictor of all-cause mortality in humans; however, its role in the development of obesity and susceptibility for high fat diet (HFD)-induced weight gain is not completely understood.
Methods
Herein, we utilized a rodent model system of divergent intrinsic aerobic capacity [high capacity running (HCR) and low capacity running (LCR)], to evaluate the role of aerobic fitness on 1-week HFD-induced (45% & 60% kcal) weight gain. Food/energy intake, body composition analysis, and brown adipose tissue gene expression were assessed as important potential factors involved in modulating HFD-induced weight gain.
Results
HCR rats had reduced 1-week weight gain on both HFDs compared to LCR. Reduced HFD-induced weight gain was associated with greater adaptability to decrease food intake following initiation of the HFDs. Further, the HCR rats were observed to have reduced feeding efficiency, greater brown adipose mass, and expression of genes involved in thermogenesis.
Conclusion
Rats with high intrinsic aerobic capacity have reduced susceptibility to 1-week HFD-induced weight gain, which is associated with greater food intake adaptability to control intake of energy dense HFDs, reduced weight gain per kcal consumed, and greater brown adipose tissue mass and thermogenic gene expression.