The effect of thermopreference on circadian thermoregulation in sprague-dawley and fisher 344 rats

Brown, Justin W.; Pham-Le, Nhut M.

doi:10.1016/j.jtherbio.2011.09.006

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…However, the majority of the identified studies investigating thermopreference found that preference depended on a moderating factor. Photoperiod moderated temperature preference in three choice tests, with rats preferring cooler temperatures during the dark phase [61][62][63] . Three choice studies also found strain differences in temperature preferences: Sprague Dawleys preferred lower temperature than Fischer rats, Long Evans preferred lower temperatures than Sprague Dawley and Fischer rats [63][64][65] .…”

Section: Refinements That Have Been Studied?mentioning

confidence: 99%

“…Photoperiod moderated temperature preference in three choice tests, with rats preferring cooler temperatures during the dark phase [61][62][63] . Three choice studies also found strain differences in temperature preferences: Sprague Dawleys preferred lower temperature than Fischer rats, Long Evans preferred lower temperatures than Sprague Dawley and Fischer rats [63][64][65] . Body weight 66 , previous experience 67 , and the presence of nesting material also altered temperature preferences in choice tests 68 .…”

Section: Refinements That Have Been Studied?mentioning

confidence: 99%

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A mapping review of refinements to laboratory rat housing and husbandry

et al. 2023

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Refining the housing and husbandry of laboratory rats is an important goal, both for ethical reasons and to allow better quality research. We conducted a mapping review of 1,017 studies investigating potential refinements of housing and husbandry of the laboratory rat to assess what refinements have, and haven't, been studied, and to briefly assess whether there is evidence to support any impact on rat welfare. Among the many refinements studied, the majority involve changes to the cage, but some also involve alterations to the wider environment. The effects of these refinements were assessed using a range of readouts, many of which are difficult to interpret from a welfare perspective. Preference studies, which are easier to interpret, provide evidence that rats prefer complex environments, including shelters and multiple objects, which offer different areas/resources allowing the rat to engage in diverse behaviours. The reporting of methodology in papers was often poor, indicating that studies were potentially subject to biases. Given that many refinements co-occurred, it was often difficult to tease apart which ones were most beneficial for rat welfare. Effects of refinements were also moderated by a number of factors including age, sex, strain, and photoperiod. Altogether our findings show that a one-size-fits-all approach to refinements is not appropriate, because different refinements will impact different rats in different ways. Our review has also produced a database of >1,000 articles that can be used for further and more detailed analyses. Our findings have also highlighted areas where future research is likely to be valuable, including refinements to rat transport, handling, and the use of training.

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Section: Refinements That Have Been Studied?mentioning

confidence: 99%

Section: Refinements That Have Been Studied?mentioning

confidence: 99%

A mapping review of refinements to laboratory rat housing and husbandry

et al. 2023

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“…We surveyed the literature (4,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) for the normal body temperature range of various homeotherms (Fig. 1A).…”

Section: Fruit Bat Trpv1 With a Lower Heat Activation Thresholdmentioning

confidence: 99%

A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds

Tian

Yao

et al. 2020

Journal of Biological Chemistry

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The transient receptor potential vanilloid 1 (TRPV1) channel is a heat-activated cation channel that plays a crucial role in ambient temperature detection and thermal homeostasis. Although several structural features of TRPV1 have been shown to be involved in heat-induced activation of the gating process, the physiological significance of only a few of these key elements has been evaluated in an evolutionary context. Here, using transient expression in HEK293 cells, electrophysiological recordings, and molecular modeling, we show that the pore turret contains both structural and functional determinants that set the heat activation thresholds of distinct TRPV1 orthologs in mammals whose body temperatures fluctuate widely. We found that TRPV1 from the bat Carollia brevicauda exhibits a lower threshold temperature of channel activation than does its human ortholog and three bat-specific amino acid substitutions located in the pore turret are sufficient to determine this threshold temperature. Furthermore, the structure of the TRPV1 pore turret appears to be of physiological and evolutionary significance for differentiating the heat-activated threshold among species-specific TRPV1 orthologs. These findings support a role for the TRPV1 pore turret in tuning the heat-activated threshold, and they suggest that its evolution was driven by adaption to specific physiological traits among mammals exposed to variable temperatures.

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“…Disparities in the physiology of different rat strains have been increasingly reported in the literature throughout the last decade, implying that the choice of strain, or even the animal supplier, can have a significant impact on the outcome of experiments (Smitvan Oosten et al 2002, Van den Buuse & Wegener 2005, Palm et al 2011, Brown & Pham-Le 2012, Fuzik et al 2013. For that reason, it is of the utmost importance to test the same treatment regimen in more than one strain to elucidate whether the effects that are obtained are general phenomena or are specific to a certain strain.…”

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confidence: 99%

Prevention of duodenal ileus reveals functional differences in the duodenal response to luminal hypertonicity in Sprague‐Dawley and Dark Agouti rats

2013

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The duodenum possesses the ability to absorb fluid despite a very high luminal osmolality. Inhibition of cyclooxygenase-2 markedly enhanced the capability of the duodenum to secrete fluid and to decrease luminal osmolality, irrespective of the hyperosmolar solution or the rat strain used, and revealed notable differences between the two strains with regard to their osmolality-adjusting capability.

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The effect of thermopreference on circadian thermoregulation in sprague-dawley and fisher 344 rats

Cited by 5 publications

References 17 publications

A mapping review of refinements to laboratory rat housing and husbandry

A mapping review of refinements to laboratory rat housing and husbandry

A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds

Prevention of duodenal ileus reveals functional differences in the duodenal response to luminal hypertonicity in Sprague‐Dawley and Dark Agouti rats

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