The effect of thiol-disulfide homeostasis in patients undergoing on-pump coronary artery bypass grafting

Sanrı, Umut Serhat; Toktaş, Faruk; Balcı, Abdullah Burak; Üstündağ, Yasemin; Huysal, Kağan; Erel, Özcan; Yavuz, Şenol

doi:10.5606/tgkdc.dergisi.2019.18033

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…In the case of decreased NT and TT levels, disulfide/ TT or NT level is also expected to decrease as an indication of an effective antioxidant mechanism 9 . The value of the thiol/disulfide homeostasis was previously studied in infertile men with varicocele, 14 patients undergoing coronary artery bypass grafting, 15 pediatric patients with febrile convulsion, 16 and acute pancreatitis 17 for the prediction of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

The effects of pre‐emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C‐reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial

2021

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Aims In this study, we aimed to investigate the anti‐inflammatory and antioxidant effects of intravenous ibuprofen by using the C‐reactive protein level and thiol/disulfide homeostasis as the oxidative stress marker. Materials and Methods This study was conducted on 70 patients aged between 30 and 65 who were scheduled for elective laparoscopic hysterectomy. The patients were divided into two groups to receive either pre‐emptive 800mg of intravenous ibuprofen plus 1000 mg of intravenous paracetamol (Group IP) or only 1000 mg of intravenous paracetamol as a control group (Group P). The blood samples for thiol/disulfide homeostasis were collected as follows: before induction of anesthesia (T0), before pneumoperitoneum (T1), following postdeflation and discontinuation of anesthesia (T2), and postoperative 24th hour (T3). Simultaneous blood samples for C‐reactive protein (CRP) were also collected. The pre‐ and postoperative urea, creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels were measured. Results A total of 69 patients were included in the study. The patient's characteristics and intraoperative variables were comparable between groups (P > .05). The number of patients requiring rescue analgesia, the total amount of analgesic used, Visual Analog Scale (VAS) scores, and postoperative side effects were significantly lower in Group IP (P < .001). The decrease in native and total thiol levels at T1, T2, and T3 measurement points was significant in Group IP (P < .001). In both groups, the comparison to baseline values demonstrated no significant changes in terms of disulfide level (P > .05). The simultaneous CRP levels indicated a significant increase at the postoperative 24 hour in both groups (P < .001). The difference between groups was insignificant (P > .05). There was a significant increase in urea and creatinine levels in patients of Group IP (P < .05). Conclusion The pre‐emptive administration of ibuprofen provided effective pain control after gynecologic laparoscopy. However, ibuprofen changed the thiol/disulfide homeostasis in favor of oxidation and had no beneficial effect in surgically induced oxidative stress.

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Section: Discussionmentioning

confidence: 99%

The effects of pre‐emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C‐reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial

2021

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“…In a recent study, the relationship of thiol-disulfide hemostasis parameters with cross-clamp times and their effectiveness in predicting postoperative rhythm disorders were investigated in CABG-guided CABG operations (12). 51 patients were included in the study and blood samples were measured 3 times, preoperatively, immediately after the cross-clamp was removed, and at the postoperative sixth hour.…”

Section: Discussionmentioning

confidence: 99%

The Role of Thiol-Disulfide Hemostasis in Predicting Renal İnjury After Coronary Artery Bypass Graft Surgery

et al. 2021

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EInflammation andoxidative stres play an active role in renal injury that develops after open heart operations as in many diseases. There is a balance between oxidants and antioxidant defense mechanisms, and in the morbidity of cardiac surgery patients, this balance is thought to change depending on many factors. Materials and Methods: 76 patients scheduled for coronary artery bypass graft surgery were included in the study. Demographic and operation information of the patients were recorded. In addition to routine blood parameters, blood samples were taken forthiol / disulfid hemostasis parameters. Patients who did not develop acut kidney injury (AKI) after the operation were recorded as Group 1 and those who developed register as Group 2. Results: Postoperative AKI developed in 19 (25%) patients included in the study. When the thiol-disulfide hemostasis parameter values obtained from the blood sample taken within the first 2 hours after the introduction of intensive care after the operation of the patients, there was no difference between the two groups in terms of native thiol, total thiol, disulfide / native thiol and native thiol / total thiol values. In Group 2, disufide and disulfide / total thiol values were significantly higher (P = 0.018, P = 0.009). Conclusion:We believe that the values of disulfide and disulfide / total thiol ratio, which are among the parameters of thiol-disulfide hemostasis, in the postoperative period may be predictors for AKI.

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“… 14 , 15 Embora a importância do metabolismo de tióis tenha sido avaliada para procedimentos e doenças cardiovasculares diferentes, tais como o infarto do miocárdio ou cirurgia para ponte arterial, sua expressão em DCR não é conhecida. 14 , 16 Neste estudo, devido ao componente fisiopatológico da DVR, buscamos avaliar os níveis de tiol em pacientes com DVMR e em sujeitos saudáveis.…”

Section: Introductionunclassified

“… 14 , 15 Although the importance of thiol metabolism was evaluated in different cardiovascular diseases and procedures, such as myocardial infarction or coronary artery bypass surgery, its expression in RHD is unknown. 14 , 16 This study, due to the pathophysiological component of RVD, aimed to evaluate the thiol levels in RMVD patients and healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

Níveis de Tiol Sérico e Homeostase Tiol/Dissulfeto em Pacientes com Doença Valvar Mitral Reumatismal e em Sujeitos Saudáveis

Korkmaz¹,

Doğanay²,

Başyiğit³

et al. 2021

Arquivos Brasileiros De Cardiologia

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Fundamento: A doença valvar mitral reumatismal (DVMR) é a apresentação mais comum das doenças cardíacas reumáticas (DCR). Os processos de inflamação e fibrose também têm papéis significativos em sua patogênese. Estudos recentes demonstram que os tióis e o tiol-dissulfeto são marcadores de stress oxidativo inéditos e promissores. Objetivos: O objetivo deste estudo foi avaliar diferenças entre os níveis de tiol sérico e de tiol-dissulfeto em pacientes com DVMR e no grupo de controle. Métodos: Noventa e dois pacientes com DVMR foram cadastrados no estudo. Cinquenta e quatro sujeitos saudáveis, e com correspondência de sexo e idade em relação ao grupo de estudo, também foram incluídos no estudo como um grupo de controle. Foram investigados os níveis de tiol nos pacientes com DVMR e o grupo de controle. Os p-valores menores que 0,05 foram considerados estatisticamente significativos. Resultados: Os pacientes com DVMR apresentaram pressão sistólica da artéria pulmonar (PSAP) e níveis de diâmetro do átrio esquerdo (AE) mais altos que os do grupo de controle. Os níveis de tiol nativo (407±83 μmol/L vs. 297±65 μmol/L, p<0,001) e tiol total (442±82 μmol/L vs. 329±65 μmol/L, p<0,001) são mais altos no grupo de controle. Níveis de dissulfeto (16,7±4,9 μmol/L vs. 14,8±3,7 μmol/L, p=0,011) são mais altos no grupo de pacientes com DVMR. Foi identificada uma correlação positiva entre as razões dissulfeto/tiol nativo e dissulfeto/tiol total com PSAP, diâmetro de AE, e gravidade da EMi. A razão dissulfeto/tiol total é significativamente mais alta em pacientes com EMi grave que em pacientes com EMi leve a moderada. Conclusões: Até onde se sabe, este é o único estudo que avaliou a homeostase tiol/dissulfeto como um preditor inédito, que está relacionado de forma mais próxima à DVMR e à gravidade da EMi.

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The effect of thiol-disulfide homeostasis in patients undergoing on-pump coronary artery bypass grafting

Cited by 9 publications

References 24 publications

The effects of pre‐emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C‐reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial

The effects of pre‐emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C‐reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial

The Role of Thiol-Disulfide Hemostasis in Predicting Renal İnjury After Coronary Artery Bypass Graft Surgery

Níveis de Tiol Sérico e Homeostase Tiol/Dissulfeto em Pacientes com Doença Valvar Mitral Reumatismal e em Sujeitos Saudáveis

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