The effect of thyroid dysfunction on breast cancer risk: an updated meta-analysis

Tran, Thi-Van-Trinh; Kitahara, Cari M.; Leenhardt, Laurence; Vathaire, F. de; Boutron‐Ruault, Marie‐Christine; Journy, Neige

doi:10.1530/erc-22-0155

Cited by 9 publications

(8 citation statements)

References 43 publications

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“…The mechanism by which the thyroid gland affects breast tumorigenesis is uncertain 11,12 . However, our earlier ndings imply that HypoT in uences mammary carcinogenesis by modifying body development, body composition, morphology of the mammary gland, adipose tissue, and release of adipokines 15 .…”

Section: Discussionmentioning

confidence: 99%

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Hypothyroidism and Mammary Cancer: Role of Peritumoral Adipose Tissue

Zyla

Santiano

Bruna

et al. 2023

Preprint

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To study the effects of HypoT on rat mammary tumor-associated adipose tissue and its ability to modify the biological behavior of breast cancer epithelial cells, we evaluated changes in the viability, proliferation, apoptosis, adhesion, and migration of tumorigenic (MCF-7, MDA-MB-231) and non-tumorigenic (MCF-10A) mammary cells incubated with the conditioned media from mammary adipose tissue (MAT-CMs) of HypoT and euthyroid (EUT) rats with and without mammary tumors. Female Sprague-Dawley rats were treated with 7, 12-Dimethylbenz[a]anthracen (15mg/rat) at 55 days of age to induce mammary tumors and were divided at random in HypoT (0.01% 6-N-propyl-2-thiouracil in drinking water, n = 30) and EUT (tap water, n = 30). Fragments of MAT were incubated for 24 h with M199 medium, and MAT-CMs were collected. MCF-7, MDA-MB-231, and MCF-10A were incubated with non-tumor and tumor MAT-CMs, and viability, proliferation, apoptosis, adhesion, and migration were quantified. Non-tumor MAT-CMs of HypoT rats favored apoptosis of MCF-10A; decreased the viability and adhesion of MCF-7; promoted proliferation, and decreased the adhesion of MDA-MB-231. Tumor MAT-CMs of HypoT rats stimulated proliferation in tumorigenic cells and inhibited apoptosis of MCF-10A. Non-tumor MAT-CMs of HypoT rats may protect against tumorigenesis while tumor MAT-CMs of HypoT may favor a more tumorigenic behavior of mammary tumor cells.

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Section: Discussionmentioning

confidence: 99%

“…A potential link between thyroid conditions and breast cancer has been discussed for decades [10][11][12] . It has been shown that hyperthyroidism is related to an increased incidence and aggressiveness of breast cancer whereas hypothyroidism (HypoT) is associated with a lower incidence of the disease 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Hypothyroidism and Mammary Cancer: Role of Peritumoral Adipose Tissue

Zyla

Santiano

Bruna

et al. 2023

Preprint

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“…18 Among the indicators of less aggressive course was decreased metastatic disease. Other clinical studies have also found that decreased thyroid function may protect against breast cancer 19,20 and that endogenous trends toward increased thyroid function enhances breast cancer risk. 21,22 Of additional interest is that thyroid hormone replacement therapy may be a breast cancer risk factor.…”

Section: Thyroid Hormones and Clinical Behavior Of Breast Cancermentioning

confidence: 94%

Overlapping Actions of L-Thyroxine (T4) and Steroids in Breast Cancer Cells: Mediation by Cell Surface Integrin αvβ3

Hercbergs,

Lin,

Mousa

et al. 2023

MRAJ

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The overlap of actions of nonpeptide small endocrine molecules—thyroid hormone and steroids—include two panels of actions. One set is initiated at the nuclear receptors for these hormones and a second set of actions for both hormones is initiated at the extracellular domain of plasma membrane integrin αvβ3. This brief review is concerned with integrin-based receptors on breast cancer cells. On such cells, thyroid hormone as L-thyroxine (T4) at physiological concentrations can stimulate proliferation of breast cancer cells via the thyroid hormone analogue receptor on αvβ3 and, in the absence of estrogen, via the nuclear estrogen receptor-α (ER α). Such observations emphasize the postmenopausal relevance of nuclear estrogen receptor. The deaminated T4 derivative, tetraiodothyroacetic acid (tetrac), blocks T4 actions at the integrin. An androgen receptor on the integrin mediates stimulation of breast cancer cell proliferation by dihydrotestosterone (DHT). T4 controls the activation state of the integrin, a factor that may determine the accessibility of the androgen receptor on αvβ3 to DHT and thus to DHT-driven cell proliferation. An estrogen receptor appears to be present on the integrin, but its functions have not been defined. It is not yet known whether tetrac alters function of the steroid receptors that are adjacent to the T4 binding site on αvβ3. The overlap of T4 and steroid functions in breast cancer cells may offer additional options for clinical management of this type of cancer.

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“…И напротив, дисфункция гормонов ЩЖ, в частности гипертиреоз, может свидетельствовать о высоком риске рака молочной железы (в контексте изучения роли менопаузы), как показал один из последних метаанализов, опубликованный в начале 2023 г. [29]. К сожалению, на этом связь грудного вскармливания со злокачественными новообразованиями не заканчивается.…”

Section: грудное вскармливание и риск развития онкологииunclassified

Prenatal nursing care is essential! Breastfeeding: focus on maternal health

Zakharova,

Kuchina,

Kholodova

et al. 2023

Medicinskij sovet

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This article deals with the importance and necessity of breastfeeding for both mother and baby. The timeliness of this topic has been brought about by technological advances, which imposes its own rules and offers alternatives in which it seems much easier to neglect the main maternal responsibility – the role of the breastfeeding mother. One gets the feeling that scientific research into breast milk is limited to finding evidence of the benefits of breastfeeding to convince novice mothers to breastfeed. The article mentions the evolutionary significance of breastfeeding, explains the reasons for the mammary glands “suffering” if the only “evolutionarily assigned” function for this female organ is not implemented, which makes us look at the need for natural breastfeeding from a different angle. Evidence of the need for breastfeeding to prevent the development of breast cancer that has high mortality rates in the female population is presented. At the same time, the issue of malignant tumours is not limited only to the mammary glands. The role of the breast milk microbiota disorders in the formation of the above processes is discussed. The preventive role of breastfeeding in the development of metabolic disorders, cardiovascular and endocrine diseases in women has been shown. The article presents data on this issue from numerous clinical studies, reviews and meta-analyses. The emphasis was placed on the prenatal discussions with pregnant women about the importance and necessity of breastfeeding, which should be carried out at the stage of preparing women for childbirth. The question has been raised about the role of the local paediatrician in the prenatal nursing care for women. It explains why “early” acquaintance with the mother is far from being an additional needless burden for the local paediatrician, as it might seem at first glance, but rather, on the contrary, additional opportunities.

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The effect of thyroid dysfunction on breast cancer risk: an updated meta-analysis

Cited by 9 publications

References 43 publications

Hypothyroidism and Mammary Cancer: Role of Peritumoral Adipose Tissue

Hypothyroidism and Mammary Cancer: Role of Peritumoral Adipose Tissue

Overlapping Actions of L-Thyroxine (T4) and Steroids in Breast Cancer Cells: Mediation by Cell Surface Integrin αvβ3

Prenatal nursing care is essential! Breastfeeding: focus on maternal health

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