The effect of tonsillectomy on the immune system: A systematic review and meta-analysis

Bitar, Mohamad; Dowli, Alexander; Mourad, Marc

doi:10.1016/j.ijporl.2015.05.016

Cited by 35 publications

(26 citation statements)

References 28 publications

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“…Bitar et al . reported recently about the effect of tonsillectomy on the immune system . Only four (11.4%) studies, including 406 (20.3%) patients, found that tonsillectomy negatively affects the immune system and more evidence suggests that tonsillectomy has no negative clinical or immunological sequelae on the immune system.…”

Section: Discussionmentioning

confidence: 99%

Tonsillectomy and inflammatory bowel disease: a meta‐analysis

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Tonsillectomy and inflammatory bowel disease: a meta‐analysis

et al. 2016

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“…Surgical indications for this procedure have varied over the years, although they focus on the prevention of recurrent infections and the treatment of OSAS. The effect of tonsillectomy on inflammatory biomarkers has yielded conflicting results, and it is speculated that tonsillectomy negatively affects the immune system in children since the production of specific antibodies and B‐ and T‐cell activity in response to several antigenic stimuli is higher in the first years of life …”

Section: Introductionmentioning

confidence: 99%

“…The effect of tonsillectomy on inflammatory biomarkers has yielded conflicting results, and it is speculated that tonsillectomy negatively affects the immune system in children since the production of specific antibodies and B-and T-cell activity in response to several antigenic stimuli is higher in the first years of life. 10 Hence, the impact of surgery on this lymphatic tissue and the long-term outcome of chronic tonsillar inflammation in children is a matter of interest.…”

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confidence: 99%

Impact of adenotonsillectomy on the evolution of inflammatory markers

Marcano-Acuña

Carrasco-Llatas

Tortajada‐Girbés

et al. 2019

Clinical Otolaryngology

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Background Tonsils are first‐line host defence organs against pathogenic agents and participate in local and systemic immunity. Persistent increases in systemic inflammatory responses may contribute to associated morbidity. The aim of this study was to verify the short‐ and long‐term impact of adenotonsillectomy on the evolution of inflammatory markers in 3‐ to 9‐year‐old children. Methods A prospective and longitudinal study was conducted over 1 year in 29 children who underwent tonsillectomy due to either chronic tonsillitis or adenotonsillar hypertrophy. Measurements of high‐sensitivity C‐reactive protein (hs‐CRP) levels were taken. Levels of Th1‐type cytokines [interleukin‐1, interferon‐γ, and tumor necrosis factor‐Î± (TNF‐α)] and anti‐inflammatory Th2‐type cytokines [interleukin‐4, ‐5, ‐6, ‐10 and ‐13] were measured. Levels of transforming growth factor‐beta (TGF‐β) and intercellular adhesion molecule‐1 (ICAM‐1) were also determined. The results were compared to those of 29 control children. Results At baseline, children with surgery indications presented with higher levels of hs‐CRP, interleukin‐1 and ‐10, interferon‐γ, TNF‐α and ICAM‐1, whereas values of interleukin‐4 were significantly lower than in control children. Children with severe tonsillar obstruction had higher values of interleukin‐1, ‐4, and ‐5 and lower values of interleukin‐10 compared with children with recurrent tonsillitis. One year after surgery, the levels except IL‐4 did not show a significant difference from those obtained in the control group. The levels of hs‐CRP and TNF‐α decreased significantly in the first month. Conclusion Children with chronic tonsillitis and/or adenotonsillar hypertrophy have significantly elevated levels of proinflammatory cytokines. Adenotonsillectomy restores the normal values of these parameters 1 year after surgery.

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“…Esta teoría, basada en el rol inmune que posee el tejido adenoamigdalino, está muy difundido dentro de la población general. Aún así, tanto la experiencia clínica como los últimos estudios realizados en pacientes pediátricos desmienten esta teoría, demostrando que tanto la inmunidad humoral como la celular se mantienen casi intactas posterior al procedimiento 21 , tanto a corto como a largo plazo [22][23][24] . Pudiese existir una disminución respecto a los valores preoperatorios en niños con un sistema inmune "exaltado", sometido a amigdalitis/ adenoiditis crónica o debido a la misma hiperplasia de ambas, sin embargo a pesar del descenso, los valores de inmunoglobulinas y células inmunes se mantiene en rangos normales 24 .…”

Section: Inmunidad Posterior a La Cirugíaunclassified

Amigdalectomía y adenoidectomía: Conceptos, técnicas y recomendaciones

et al. 2016

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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La cirugía de adenoides y amígdalas es de los procedimientos más frecuentemente realizados dentro de la especialidad, y de las operaciones más comunes en niños. Actualmente, la indicación más común es la hiperplasia asociada a trastornos del sueño, desplazando a las infecciones recurrentes como primera causa de cirugía. Debido a esto, es importante conocer los aspectos relevantes en cuanto a anatomía, fisiología, indicaciones, técnica quirúrgica y complicaciones del procedimiento. Esta revisión pretende presentar el estado del arte actual y entregar una guía inicial a los especialistas en formación, así como una actualización para quienes ya poseen experiencia dentro de la otorrinolaringología.

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The effect of tonsillectomy on the immune system: A systematic review and meta-analysis

Cited by 35 publications

References 28 publications

Tonsillectomy and inflammatory bowel disease: a meta‐analysis

Tonsillectomy and inflammatory bowel disease: a meta‐analysis

Impact of adenotonsillectomy on the evolution of inflammatory markers

Amigdalectomía y adenoidectomía: Conceptos, técnicas y recomendaciones

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