The effect of total fasting on thyroid function in man

Wd, Alexander; Mt, Harrison; Rm, Harden; Da, Koutras

doi:10.1016/0026-0495(64)90067-8

Cited by 20 publications

(8 citation statements)

References 4 publications

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“…Estimates of the concentration of iodide in plasma were decreased in all four patients studied during mannitol diuresis and had decreased even further by the time of the postdiuresis test. In the remain4These doubts concerning the efficacy of simple fasting as a means of inducing uncomplicated iodide depletion have recently been verified by studies which have demonstrated that a total fast of 1 to 3 days duration not only fails to decrease the iodide concentration in plasma, but also leads to decreases in both thyroid iodide clearance rate and absolute iodine accumulation (38). Several indexes provided evidence that thyroid function had increased as a consequence of the iodide depletion procedures carried out.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Acute Iodide Depletion on Thyroid Function in Man*

Barakat¹,

Ingbar²

1965

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

The Effect of Acute Iodide Depletion on Thyroid Function in Man*

Barakat¹,

Ingbar²

1965

J. Clin. Invest.

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“…However, a tendency towards low serum PBI levels has been reported in obese patients whose serum free fatty acid level was not reduced by adrenaline (Goldberg and Gordon, 1964). In one group of obese patients fasting lowered the serum PBI level by The interpretation of the serum protein-bound iodine: A review 1 ,tg/100 ml and also lowered the thyroid absolute iodine uptake (Alexander, Harrison, Harden, and Koutras, 1964). In another group of obese patients fasting was found not to affect the serum PBI (Schatz, Sheppard, Palter, and Jaffri, 1967).…”

Section: Disorders Of Metabolismmentioning

confidence: 92%

The interpretation of the serum protein-bound iodine: A review

Acland

1971

J Clin Pathol

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“…Goiter may be induced by the high serum level of inorganic iodide (1,2,10) or retention of goitrogenic substances normally excreted by the kidney (11). Finally, malnutrition may be a contributing factor in altering thyroid function tests (12).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Dysfunction in Chronic Renal Failure

Lim¹,

Fang²,

Katz³

et al. 1977

J. Clin. Invest.

219

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A B S T R A C T Thyroid function was evaluated in 46patients with end-stage kidney disease and 42 normal subjects. Patients were studied before and after the institution of maintenance hemodialysis (HD) and after renal transplantation (RT). Serum total triiodothyronine concentrations (TT3, ng/100 ml, mean± SD) were 63±17 and 83±22 in the non-HD and HD groups, respectively. Values from normal subjects were 128±25 and from RT patients 134±20. The TT3 was in the hypothyroid range (<78 ng/100 ml; 2 SD below normal mean) in 80% of non-HD and 43% of HD patients. Mean serum total thyroxine concentration (TT4), although within the normal range, was lower than the control value. T4-binding globulin capacity was also slightly lower but the difference was not statistically significant. Among patients whose TT4 was 1 SD below the normal mean, the free T4 index was equally depressed, suggesting that factors other than decreased binding capacity might be responsible for the low TT4. In addition, there was a 37% incidence of goiter. Mean serum thyroid-stimulating hormone (TSH) was not elevated and the TSH response to thyrotropinreleasing hormone (TRH) was distinctly blunted, suggesting the possibility of pituitary dysfunction as well. In vivo '25I-L-T4 and 13'I-L-T3 kinetics during 0.2 mg/day of L-T4 replacement showed marked reduction in T3 turnover rate in the uremic patients, both before and during HD; the values (,tg T3/day, mean±SD) for the different groups were as follows: normal, 33.8+6.1; non-HD, 13.5±2.6; HD, 12.9±3.1; and RT, 30.3±7.1.The low T3 turnover rate was due to impaired extrathyroidal conversion of T4 to T3. The mean perThis work was presented in part at the 50th Annual

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The effect of total fasting on thyroid function in man

Cited by 20 publications

References 4 publications

The Effect of Acute Iodide Depletion on Thyroid Function in Man*

The Effect of Acute Iodide Depletion on Thyroid Function in Man*

The interpretation of the serum protein-bound iodine: A review

Thyroid Dysfunction in Chronic Renal Failure

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