2015
DOI: 10.1155/2015/518454
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The Effect of Tou Nong San on Transplanted Tumor Growth in Nude Mice

Abstract: Tou Nong San (TNS) is a traditional Chinese medicinal decoction used to treat sores and carbuncles. It contains four herbal drugs and one animal medicine: Radix Astragaliseu Seu Hedysari, Angelica sinensis, Ligustici Chuanxiong, Spina Gleditsiae, and stir-baked Squama Manis. Previous studies have shown that it has anticancer effects. This report validates in vivo antitumor properties of TNS. The compounds contained in TNSE were confirmed by liquid chromatographmass spectrometer (LC-MS) analysis. The in vivo an… Show more

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Cited by 6 publications
(4 citation statements)
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“…Compound 13 could generate the ions [M-H]at m/z 267.0665, [M-H-CH 3 ]at m/z 252.0434, [M-H-O]at m/z 251.0349, [M-H-CO 2 ]at m/z 223.0393, and [M-H-CO 2 -CO]at m/z 195.0454 at low and high collision energy.The intensity of ions at m/z 252.0434 was stronger than that of ions at m/z 251.0349, which was obviously different from the distribution of isotope ions. Hence, the ions at m/z 252.0434 and 251.0349 were all assigned as the fragments of formononetin[34].…”
mentioning
confidence: 99%
“…Compound 13 could generate the ions [M-H]at m/z 267.0665, [M-H-CH 3 ]at m/z 252.0434, [M-H-O]at m/z 251.0349, [M-H-CO 2 ]at m/z 223.0393, and [M-H-CO 2 -CO]at m/z 195.0454 at low and high collision energy.The intensity of ions at m/z 252.0434 was stronger than that of ions at m/z 251.0349, which was obviously different from the distribution of isotope ions. Hence, the ions at m/z 252.0434 and 251.0349 were all assigned as the fragments of formononetin[34].…”
mentioning
confidence: 99%
“…(5) Seven major components in the ethanol extracts of TNS were determined by LC-MS analysis in our study which was consistence with our previous study. (29) Furthermore, these compound concentrations in the ethanol TNSEs were much higher than those in the water soluble TNSEs (data not shown). Therefore, the ethanol extracts of TNS were chosen in our study.…”
Section: Discussionmentioning
confidence: 88%
“…When conducting qualitative analysis, we can obtain structural information through scanning positive or negative ions [3]. We can also make it clear which kind of substance the chemical structure belongs to by comparing it with the standard literatures [3, 4]. The LC-Q-MS quantifies compounds based on the selection of specific ions for monitoring [5].…”
Section: Lc-msmentioning
confidence: 99%