Tounong Powder (透脓散) extracts induce G1 cell cycle arrest and apoptosis in LoVo cells

Fang, Liang-hua; Liu, Shenlin; Wang, Ruiping; Hu, Sindy; Ju, Wen-zheng; Li, Chang-Yin

doi:10.1007/s11655-016-2597-8

Cited by 2 publications

(5 citation statements)

References 22 publications

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“…Subsequently, precise ultrasound-guided debridement surgery was performed. After 2 months of conventional dressing change and treatment with Traditional Chinese Medicine ( 19 ), the lesion had healed and the mass had subsided.…”

Section: Resultsmentioning

confidence: 99%

“…During the treatment, obstruction of the negative pressure drainage tube was avoided, the amount and characteristics of the drainage fluid were observed and the negative pressure drainage material was replaced once a week. Traditional Chinese Medicine, such as Tounong Powder ( 19 ), was administered according to the symptoms.…”

Section: Methodsmentioning

confidence: 99%

“…After there was no purulent exudation, the gauze strip was removed and the wound was closed with elastic bandages and gauze under pressure. Prior to and after the operation, all patients were treated with Traditional Chinese Medicine ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

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Clinical therapeutic evaluation of vacuum sealing drainage and precise ultrasound‑guided debridement in the treatment of non‑lactational mastitis

Chen

Peng

et al. 2021

Exp Ther Med

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The aim of the present study was to compare the efficacy of vacuum sealing drainage (VSD) and precise ultrasound-guided debridement in the treatment of non-lactational mastitis and to determine the optimal surgical treatment. A set of 60 cases diagnosed with non-lactational mastitis who had received surgical treatment at the Department of Thoracic and Breast Surgery of Xiamen Hospital of Traditional Chinese Medicine (Xiamen, China) between July 2017 and June 2019 were included. According to the surgical method, 30 patients were assigned to the VSD group and 30 patients were assigned to the precise ultrasound-guided debridement group. The clinicopathological data of the two groups were compared. The overall rates of recurrence and new incidence were 6.8 and 8.5%, respectively. The mean total disease course was 5.3 months and all of the patients were cured after treatment. Except for the hospitalization time and postoperative pain scores, the clinicopathological data between the two groups were similar. The hospitalization time in the VSD group was significantly longer than that in the precise ultrasound-guided debridement group. Pain scores on the first and third days after the operation in the precise ultrasound-guided debridement group were significantly higher than those in the VSD group (P=0.008 and 0.001, respectively). In conclusion, the efficacies of VSD and precise ultrasound-guided debridement for the treatment of non-lactational mastitis were generally both satisfactory without significant differences. Of note, the former is suitable for patients with inverted nipples and obvious skin ulcerations, while the latter is mainly suitable for patients with abscesses, small surgical incisions and those who require short hospital stays.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Clinical therapeutic evaluation of vacuum sealing drainage and precise ultrasound‑guided debridement in the treatment of non‑lactational mastitis

Chen

Peng

et al. 2021

Exp Ther Med

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“…), Zao Jiao Ci ( Gleditsia sinensis Lam. ), Chuan Shan Jia ( Manis pentadactyia Linnaeus) LoVo – Proliferation ↓, Apoptosis ↑, Block cell cycle ↑: cleaved caspase-3,cleaved caspase-9 ↓: PI3K,p-AKT, p-mTOR, p-p70s6k1 PI3K/Akt [ 56 ] Jiedu Sangen decoction (JSD) Pu Gong Ying Gen ( Taraxacum mongolicum Hand. –Mazz.…”

Section: Discussionmentioning

confidence: 99%

“…Li et al [ 55 ] found that Gegen Qinlian Decoction (GQD) could inhibit CT-26 CRC growth accompanied by upregulation of p-PI3K, p-Akt, phosphorylated forkhead box transcription factor O1 (p-FOXO1), and ankyrin repeat and BTB/POZ domain containing protein 1 (ABTB1). Fang et al [ 56 ] found that Tounong powder extracts (TNSEs) induced LoVo cell growth inhibition in a dose- and time-dependent manner; significantly downregulated the expression of PI3K, p-AKT, phosphorylated mechanistic target of rapamycin (p-mTOR), and p-p70s6k1; and upregulated the expression of cleaved caspase-9 and -3. These findings suggested that TNSEs may inhibit LoVo cells through the PI3K/Akt signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action

Chen

Shi

et al. 2023

Chin Med

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Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis, and its development involves abnormalities in multiple signaling pathways. Surgery, chemotherapy, radiotherapy, target therapy, and immunotherapy remain the main treatments for CRC, but improvement in the overall survival rate and quality of life is urgently needed. Traditional Chinese medicine (TCM) has a long history of preventing and treating CRC. It could affect CRC cell proliferation, apoptosis, cell cycle, migration, invasion, autophagy, epithelial–mesenchymal transition, angiogenesis, and chemoresistance by regulating multiple signaling pathways, such as PI3K/Akt, NF-κB, MAPK, Wnt/β-catenin, epidermal growth factor receptors, p53, TGF-β, mTOR, Hedgehog, and immunomodulatory signaling pathways. In this paper, the main signaling pathways and potential targets of TCM and its active ingredients in the treatment of CRC were systematically summarized, providing a theoretical basis for treating CRC with TCM and new ideas for further exploring the pathogenesis of CRC and developing new anti-CRC drugs.

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Tounong Powder (透脓散) extracts induce G1 cell cycle arrest and apoptosis in LoVo cells

Abstract: TNSEs reduced LoVo cell proliferation, and caused apoptosis and cell-cycle arrest in LoVo cells. This effect might be associated with regulation of the PI3K/AKT signaling pathway.

Cited by 2 publications

References 22 publications

Clinical therapeutic evaluation of vacuum sealing drainage and precise ultrasound‑guided debridement in the treatment of non‑lactational mastitis

Clinical therapeutic evaluation of vacuum sealing drainage and precise ultrasound‑guided debridement in the treatment of non‑lactational mastitis

Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action

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