The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus–pituitary–adrenal axis

Pang, Cong; Liang, Cao; Wu, Fan; Wang, Li; Wang, Gang; Yu, Yong; Zhang, Meixi; Chen, Lichao; Wang, Weijie; Lv, Weihong; Chen, Ling; Zhu, Jiejin; Pan, Jianchun; Zhang, Hanting; Xu, Ying; Ding, Liang

doi:10.1016/j.neuropharm.2015.04.017

Cited by 64 publications

(43 citation statements)

References 45 publications

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“…Taken together, when combined with a low dose (0.25 g/kg·BW/day) of Eth, Rsv tended to increase the expression of the BDNF exons tested in this study. This observation is consistent with our previous report on male rats [ 38 ] and with other published data on the effects of Rsv on the expression of BDNF in vivo or in vitro under a cytotoxic stimuli such as depression [ 82 , 83 ], Eth [ 77 ] or hypoxia [ 84 ]. In contrast to these findings, Park et al [ 85 ] showed a downregulating effect of Rsv on the expression of BDNF mRNA in both animal and cellular models.…”

Section: Resultssupporting

confidence: 93%

Effects of Ethanol on the Expression Level of Various BDNF mRNA Isoforms and Their Encoded Protein in the Hippocampus of Adult and Embryonic Rats

Shojaei

Ghavami

Panjehshahin

et al. 2015

IJMS

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We aimed to compare the effects of oral ethanol (Eth) alone or combined with the phytoestrogen resveratrol (Rsv) on the expression of various brain-derived neurotrophic factor (BDNF) transcripts and the encoded protein pro-BDNF in the hippocampus of pregnant and embryonic rats. A low (0.25 g/kg body weight (BW)/day) dose of Eth produced an increase in the expression of BDNF exons I, III and IV and a decrease in that of the exon IX in embryos, but failed to affect BDNF transcript and pro-BDNF protein expression in adults. However, co-administration of Eth 0.25 g/kg·BW/day and Rsv led to increased expression of BDNF exons I, III and IV and to a small but significant increase in the level of pro-BDNF protein in maternal rats. A high (2.5 g/kg·BW/day) dose of Eth increased the expression of BDNF exons III and IV in embryos, but it decreased the expression of exon IX containing BDNF mRNAs in the maternal rats. While the high dose of Eth alone reduced the level of pro-BDNF in adults, it failed to change the levels of pro-BDNF in embryos. Eth differentially affects the expression pattern of BDNF transcripts and levels of pro-BDNF in the hippocampus of both adult and embryonic rats.

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Section: Resultssupporting

confidence: 93%

Effects of Ethanol on the Expression Level of Various BDNF mRNA Isoforms and Their Encoded Protein in the Hippocampus of Adult and Embryonic Rats

Shojaei

Ghavami

Panjehshahin

et al. 2015

IJMS

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“…11,37,38 Few PSD studies have investigated the prefrontal cortex, although one animal model study showed that PSD rats exhibited depressionlike behavior and decreased BDNF expression in the prefrontal cortex and hippocampus, and that these symptoms were reversed and ameliorated after treatment with increasing doses of a natural polyphenol (transresveratrol). 39 The present study found that mRNA and protein expression of BDNF in the hippocampus and prefrontal cortex decreased in the CUMS and PSD+AAV groups, while intranasal administration of BDNF-HA2TAT /AAV increased BDNF mRNA and protein expression in the prefrontal cortex only. This indicates that the reduction of BDNF expression in both the hippocampus and prefrontal cortex may work synergistically in the pathogenesis of PSD in rats.…”

Section: Discussionsupporting

confidence: 45%

<p>A Study of Antidepressant Effect and Mechanism on Intranasal Delivery of BDNF-HA2TAT/AAV to Rats with Post-Stroke Depression</p>

Chen¹,

Dong²,

Liu³

et al. 2020

NDT

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Post-stroke depression (PSD) is one of the most frequent neuropsychiatric disorders associated with stroke characterized by depression. The neuroplasticity hypothesis postulates that loss of brain-derived neurotrophic factor (BDNF) plays a major role in pathophysiology of PSD, and restoration of it may represent a critical mechanism underlying antidepressant efficacy. Methods: In previous studies, we designed a new fusion gene, HA2TAT-BDNF, and cloned it into adenovirus associated virus (AAV) to construct the BDNF-HA2TAT/AAV for the delivery of BDNF to central nervous system (CNS) via nose-brain pathway. In this study, we used it to explore the antidepressant effects on PSD rats through behavioral and various histological methods, and try to find out its specific mechanism. Results: Compared with the control group, the PSD+AAV group showed decreased sucrose consumption percentage in the sucrose preference test (SPT) (P < 0.001) and prolonged immobility in the forced swimming test (FST) (P=0.000). However, the nasal administration of BDNF-HA2TAT/AAV reversed results of these two behavioral tests (P>0.05, P >0.05), showing an adequate antidepressant effect. Compared with the control group, the concentrations of BDNF mRNA and protein in the hippocampus (P< 0.05, P < 0.01) and prefrontal cortex (P < 0.01, P < 0.01) of PSD rats both decreased. Increased BDNF mRNA and protein expression was observed in the prefrontal cortex (P > 0.05, P < 0.05), without notable change in the hippocampus (P < 0.05, P < 0.001) of PSD+BDNF rats. Conclusion: These results suggest that BDNF reductions in the prefrontal cortex and hippocampus are associated with the development of post-stroke depression, and that increased levels of BDNF in the prefrontal cortex could be used as a therapeutic target to treat PSD. However, the exact mechanism of BDNF action remains unclear in this regard, hindering the wider application of our method. We expect that our research could facilitate the exploration of pathogenesis and the new treatment method of PSD.

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“…These results are in line with the previous studies where resveratrol not only offered protection against focal cerebral ischemia-induced injury, but also reversed post stroke depressive-like behavior by regulation of HPA function. In that study, resveratrol ameliorated middle cerebral artery occlusion-induced series abnormalities related to depressive-like behaviors, including an abnormal adrenal gland weight to body weight ratio, an increased expression of the corticotropin-releasing factor (CRF) in the frontal cortex, hippocampus and hypothalamus, the differential expression of glucocorticoid receptor (GR) in these three brain regions, and a decreased BDNF level; in a dose-dependent manner [38]. Further in another study, resveratrol treatment significantly reversed the chronic unpredictable mild stress induced elevated serum corticosterone levels and decreased BDNF levels in the rat hippocampus and amygdala [39].…”

Section: Discussionmentioning

confidence: 96%

Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice

et al. 2015

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The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus–pituitary–adrenal axis

Cited by 64 publications

References 45 publications

Effects of Ethanol on the Expression Level of Various BDNF mRNA Isoforms and Their Encoded Protein in the Hippocampus of Adult and Embryonic Rats

Effects of Ethanol on the Expression Level of Various BDNF mRNA Isoforms and Their Encoded Protein in the Hippocampus of Adult and Embryonic Rats

<p>A Study of Antidepressant Effect and Mechanism on Intranasal Delivery of BDNF-HA2TAT/AAV to Rats with Post-Stroke Depression</p>

Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice

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