The Effect of Traumatic Events on the Longitudinal Course and Outcomes of Youth with Bipolar Disorder

Pascual, Mireia; Levenson, Jessica C.; Merranko, John; Gill, Mary Kay; Hower, Heather; Yen, Shirley; Goldstein, Tina R.; Goldstein, Benjamin I.; Weinstock, Lauren M.; Keller, Martin B.; Axelson, David; Birmaher, Boris

doi:10.1016/j.jad.2020.05.131

Cited by 15 publications

(11 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Children and Youths with Early-Onset BD:Two early-onset studies 87,88 (Table 2) reported significant associations of CT with poor functioning, greater symptom severity 87 and a greater likelihood of co-existing mental health conditions, 88 which resemble findings in adult studies. In a preliminary summary based on this small number of studies, it is still warranted that these children and youths will need to be followed up for a longer period of time to gain greater insight.…”

Section: Dovepressmentioning

confidence: 89%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

View full text Add to dashboard Cite

Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first objective of this selective review is to characterize the short-term effects of CT in the development of BD by focusing on studies in young people. The second objective is to describe the longer-term consequences of CT by considering studies with adult participants. This review first outlines the most prominent hypotheses linking CT exposure and the onset of BD. Then, it summarizes the psychological and biological risk factors implicated in the development of BD, followed by a discussion of original studies that investigated the role of CT in young people with early-onset BD, youths at increased risk of developing BD, or young people with BD with a focus on subclinical and clinical outcome measures. The review considers additional biological and psychological factors associated with a negative impact of CT on the long-term course of BD in later adulthood. Finally, we discuss how the integration of information of CT can improve ongoing early identification of BD and mitigate severe clinical expression in later adulthood.

show abstract

Section: Dovepressmentioning

confidence: 89%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

View full text Add to dashboard Cite

show abstract

“…Patients with lifetime traumatic events had earlier BD onset, more severe symptoms, suicidal ideation, and worse psychosocial functioning [ 45 ].…”

Section: Figurementioning

confidence: 99%

What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence

et al. 2021

View full text Add to dashboard Cite

Aim: Early onset of psychopathology is often an index of a more severe clinical course and worse prognosis. This review examined the course of bipolar disorder (BD) with onset in childhood and adolescence, with a focus on persistence of symptoms, severity of illness, comorbidity, and functional impairment. Methods: The databases of PubMed, Embase, and PsycInfo were systematically searched for publications since 1990 reporting on long-term (12 months or longer) assessments of patients with early onset BD. Results: Forty-two relevant publications were identified, which reported on data derived from 15 different patient cohorts, including 7 prospective research psychopathology studies, 4 medical record reviews, 2 follow-ups of clinical trial samples, 1 managed care database, and 1 nationwide registry, for a total of 10,187 patients. The length of follow-ups ranged from 1.0 to 15 years. Diagnostic stability of BD ranged from 73% to 100% over ten years. Recovery rate from an index episode was 81.5–100% and recurrence rate was 35–67%. Suicide attempt cumulative prevalence in five years was 18–20%. Earlier age at the first episode predicted a more severe clinical course. Conclusions: Early onset BD persists over time through adolescence, with homotypic diagnostic continuity over the years, but heterogeneity in the severity of the clinical course. Whether early identification and treatment improves distal prognosis remains to be further investigated.

show abstract

“…The reviewers’ findings are largely echoed in recent longitudinal studies. Andreu Pascual et al , 23 for example, prospectively followed a large group of young people with bipolar disorder. The researchers demonstrated that the experience of at least one traumatic event in childhood was related to an earlier symptom onset, more severe affective symptoms, greater suicidal ideation, psychiatric comorbidities and greater functional impairment.…”

Section: Introductionmentioning

confidence: 99%

“…The researchers demonstrated that the experience of at least one traumatic event in childhood was related to an earlier symptom onset, more severe affective symptoms, greater suicidal ideation, psychiatric comorbidities and greater functional impairment. Additionally, Andreu Pascual et al 23 noted that people who were exposed to a traumatic event after achieving symptomatic recovery were more likely to experience an affective relapse.…”

Section: Introductionmentioning

confidence: 99%

Influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: protocol for a systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

IntroductionDespite available pharmacological and psychological treatments, remission rates for bipolar disorder remain relatively low. Current research implicates the experience of childhood trauma as a potential moderator of poor treatment outcomes among individuals with bipolar disorder. To date, the evidence reporting the influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder has not been systematically reviewed.Method and analysisMEDLINE Complete, Embase, PsycINFO and the Cochrane Central Register of Controlled Trials will be searched to identify randomised and nonrandomised studies of pharmacological and/or psychological interventions for bipolar disorder, which also assessed childhood trauma. To be eligible for inclusion, studies must have been conducted with adolescents or adults (≥10 years). Data will be screened and extracted by two independent reviewers. The methodological quality of the included studies will be assessed with the Cochrane Collaboration’s Risk of Bias tool and the Newcastle-Ottawa Scale. If deemed viable, a meta-analysis will be conducted using a random effects model. Heterogeneity of evidence will be estimated with the I² statistics.Ethics and disseminationThis systematic review will use only previously published data. Therefore, ethical approval is not required. The results will be written in concordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines, published in peer-reviewed journals and presented at relevant conferences.PROSPERO registration numberCRD42020201891.

show abstract

The Effect of Traumatic Events on the Longitudinal Course and Outcomes of Youth with Bipolar Disorder

Cited by 15 publications

References 66 publications

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence

Influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: protocol for a systematic review and meta-analysis

Contact Info

Product

Resources

About