The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000

Âkbari, Jafar; Saeedi, Majid; Morteza‐Semnani, Katayoun; Kelidari, Hamid Reza; Moghanlou, Farshad Sadegh; Zareh, Gity; Rostamkalaei, Seyyed Sohrab

doi:10.15171/apb.2015.059

Cited by 25 publications

(17 citation statements)

References 5 publications

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“…Afterward, KBr discs have been procured by compressing powders at the pressure of 5 tons in the hydraulic press for five minutes. Finally, FTIR spectra have been registered with 4 cm -1 resolution in the 4000-500 cm -1 region 12 .…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Untitled

2021

IJPSR

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This paper examined the liquisolid compact method as one of the tools for greater dissolution of the practically water-insoluble drug famotidine (FM). Therefore, the model drug, FM, has been formulated as directly compacted tablets and liquisolid compacts and then investigated for in-vitro release properties at diverse dissolution circumstances. According to the method, it is possible to convert the liquid medications of water-insoluble drugs in the non-volatile liquid vehicles into reasonably compressible and flowing powders. The formulated systems have been evaluated in terms of the pre-compression factors like the Fourier-transform infrared spectroscopy (FTIR) analysis, flow features of the liquisolid system, differential scanning calorimetry (DSC), post-compression factors, including the content uniformity, hardness, friability and weight variation, disintegration test, invitro dissolution examinations, effects of the dissolution volume as well as pH on the drug release rate and approximation of the fraction of the molecularly dispersed drug in the liquid medication. Since, the liquisolid compacts revealed notably greater drug release rates in comparison to the direct compress tablets in diverse dissolution volumes and pH, it could be concluded that this would be an encouraging approach to the improvement of dissolving the weak water-soluble drugs and formulation of the immediate release solid dose forms. INTRODUCTION:Increasing the dissolution rate of the in-soluble and or liquid lipophilic drugs for improving the absorption efficacy and bioavailability is a major objective of the drug professionals 1, 2 . A series of the widely used methods for achieving such an objective include the water-soluble salts as well as the polymorphic forms, forming water-soluble molecular complexes, lyophilization, drug micronization, solid dispersion, coprecipitation as well as micro-encapsulation; out of which, 'liquisolid compacts' has been considered a major assuring one 3-6 .

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Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

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2021

IJPSR

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“…While F10 and F9 showed 78% and 83% respectively, during 1 hour of release time, due to a lower PVP: PVA ratio. Tween 80 was chosen as the surfactant of choice due to its availability and studies identifying its effects to be greater than Tween 60 and 20 in improving solubility (24) . Tween 80 was added for both F10 and F9 at 3% W/W concentration to improve their drug release.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Formulation and Evaluation of Iornoxicam as Dissolving Microneedle Patch

Alkhiro

Ghareeb

2020

IJPS

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The objective of the study was to develop microneedle (MN) patch, with suitable properties to ensure the delivery of a therapeutic level of lornoxicam (LXM) in a period suitable to replace parenteral administration in patients, especially those who fear needles. The used polymers were cold water-soluble polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) of low molecular weight with PEG 400 as plasticizer and Tween 80 (to enhance the release) using micro molding technique. Patches were studied for needle morphology, drug content, axial fracture force measurement and drug release while the optimized formulas were further subjected to pH measurement, folding endurance, ex vivo permeation study, histopathology study, stability study and compatibility study. The patch with 11:1 ratio of PVA to PVP, 30% solid content, 5% PEG 400 and 3% Tween 80 resulted in axial needle fracture force value of (1.35 N) which is suitable for skin penetration. The release was fast with almost 100% of drug released in 60 minutes. The permeation was enhanced significantly with a steady state flux of about 3.1 times that of the solution. The lag time of MN is shorter in comparison with ordinary patch. Histopathology studies demonstrated the safety of the formulation, both stability studies and compatibility studies showed the suitability of the formulation. The results indicated that LXM microneedle patch could enhance drug permeation while achieving fast and painless administration. Keywords: Microneedle patch, Polyvinyl alcohol, Polyvinylpyrrolidone, Fracture force, Lornoxicam.

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“…Other investigators recorded an increase in the dissolution rate of a poorly soluble drug using a ternary system containing the drug with PVP K30 and Pluronic F68 (Ha et al, 2014). Tween 80 was used in a ternary solid dispersion system by Akbari to enhance dissolution of spironolactone (Akbari et al, 2015). Synergistic dissolution enhancement was recorded after preparation of ternary solid dispersion system of other poorly water soluble drugs (Rashid et al, 2015;Yan et al, 2014).…”

Section: Dissolution Studiesmentioning

confidence: 99%

Enhancement of dissolution rate and intestinal stability of candesartan cilexitil

Fayed¹,

Osman²,

Maghraby³

2016

J App Pharm Sci

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The objective of this work was to improve the dissolution rate of candesartan cilexitil, a poorly water soluble prodrug and to reduce its premature degradation in the intestinal lumen. Binary and ternary solid dispersions (SD) of the drug with Pluronic F68, Polyvinyl pyrrolidone (PVP), Hydroxypropyl Methylcellulose (HPMC) and Tween 80 were prepared using the solvent evaporation method. The dissolution rate of the drug was monitored and the prepared SD systems were characterized using thermal analysis and Fourier transform infrared (FTIR) spectroscopy. The stability of candesartan in extracted rabbit intestinal fluids was monitored. This was conducted in absence and presence of tested excipients. SD of the drug with PVP resulted in significant enhancement in the dissolution rate of drug even at the lowest drug to polymer weight ratio. Similarly, SD with HPMC showed enhanced dissolution rate. SD with Pluronic F68 showed promising dissolution enhancement but this was recorded at higher polymer concentrations. Formulation of ternary SD of the drug and PVP with either Pluronic or Tween 80 resulted in rapid drug dissolution. The enhanced dissolution was mainly due to amorphousization of the drug with possible contribution to the micelle formation as reflected from thermal analysis. Incubation of pure candesartan in intestinal fluid resulted in rapid degradation of the drug. This degradation was not affected by 0.1% Pluronic. In presence of Tween 80 the rate of drug degradation was reduced significantly with the efficacy of Tween 80 depending on its concentration. The study developed a system for enhanced dissolution rate of candesartan with better stability in the intestinal lumen.

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The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000

Cited by 25 publications

References 5 publications

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Formulation and Evaluation of Iornoxicam as Dissolving Microneedle Patch

Enhancement of dissolution rate and intestinal stability of candesartan cilexitil

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